Research shows that when soy consumption goes up, weight goes down. A new University of Illinois study may help scientists understand exactly how that weight loss happens.

"We wanted to compare the effects of soy protein hydrolysates and soy peptides with those of leptin because we hypothesized that soy might behave in the body in a similar way. Leptin is a hormone produced in our adipose tissue that interacts with receptors in the brain and signals us that were full so we stop eating," said Elvira de Mejia, a U of I assistant professor of food science and human nutrition.

The researchers wanted to see if soy protein hydrolysates could affect these regulatory hormones and their receptors.

"And we found that soy did have an effect on these mechanisms and hormones that are induced in the body to help us degrade lipids and reduce body weight, but it did so by boosting metabolism and not by reducing food intake," she said.

To compare soy peptides with leptin, de Mejias graduate student Nerissa Vaughn, with the help of associate professor Lee Beverly, implanted cannulas in the brains of lab rats; they then injected leptin as a positive control. When the scientists could see their model was working, they injected two formulations of hydrolyzed soy protein and soy peptides so the scientists could monitor the effects of each on food intake and weight loss.

Injections were given three times a week for two weeks; during that time, the animals had unlimited access to food and water. Food intake was measured 3, 6, 12, 24, and 48 hours after injection, and the rats were weighed 24 and 48 hours after injection. All rats received the same amount of exercise, and all rats lost weight.

But, after the third injection, de Mejia and Vaughn noticed a significant weight loss in the group of animals that had received one of the soy hydrolysates, even though the animals hadnt changed their eating habits. In this instance, soy p
'"/>

Contact: Phyllis Picklesimer
p-pickle@uiuc.edu
217-244-2827
University of Illinois at Urbana-Champaign
1-May-2007