How fish mend a broken heart( ibroblast growth factor (Fgf) signals....)

How fish mend a broken heart

ibroblast growth factor" (Fgf) signals. Fgf signals are known for their ability to encourage invasive cell behavior, Poss explained.

Indeed, they found, heart muscle cells produce the growth factor, while epicardial cells harbor receptors that are triggered by the signal. When the researchers experimentally blocked the Fgf signal, heart regeneration failed.

"It is tempting to speculate that the ability to mobilize epicardial cells and cultivate such a cardiogenic environment is a primary reason why zebrafish, as opposed to other laboratory models, effectively regenerate [heart muscle]," the researchers concluded. Indeed, they added, mammalian hearts typically show insufficient blood vessel growth after a heart attack.

"Experimental attempts to modify this deficiency are underway, including delivery of growth factors or bone marrow-derived cells that may promote [the formation of new blood vessels]Success in these pursuits or by directly utilizing epicardial cells or their progenitors could prove favorable for encouraging regeneration from mammalian cardiac progenitor cells."

'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
2-Nov-2006

Page: 1 2 3
Related biology news :

1. Where broken DNA is repaired
2. UT Southwestern researchers find gene mutation that leads to broken hearts
3. A broken stress response system can contribute to Gleevec resistance
4. Transplanted stem cells show promise for mending broken hearts
5. Nanotubes inspire new technique for healing broken bones
6. The selfs broken border: Tracing the role of agency attribution in schizophrenia
7. Diabetes link to obesity broken in mice
8. Single stem cells from bone heal a broken heart
9. MIT team aims to mend broken hearts
10. High blood pressure, low energy -- a recipe for heart failure
11. Abnormal fat metabolism underlies heart problems in diabetic patients

Post Your Comments:

(Date:11/25/2009)...t State University assistant professors recently r...on (NSF) to continue research beneficial to unders...90,000. , Christopher Blackwood, assistant profe... awarded grants to support two separate research p... Litter Decomposer Communities and Functions from ...

(Date:11/24/2009)...sts have crystallised a protein that may help gut ...rotein could be used by probiotic producers to ide...t to people. , "Probiotics need to interact with ...and if they attach to surfaces in the gut they are...their activity," says Dr Nathalie Juge from the In...

(Date:11/24/2009)... ROUGE Antarctica has long held secrets of the ea...recently, there has been very little information o...iles of ice for millions of years. Now, a team of ... have been funded to the tune of $10 million dolla...get to the bottom of things literally. These scie...

Breaking Biology News(10 mins):Kent State University professors focus research on the environment with grants totaling $890,000 2 A sticky solution for identifying effective probiotics 2 LSU gets to the bottom of things -- in Antarctica 2 Dr Siegal 26apos 3Bs Cookie Diet Book by Obesity Expert Sanford Siegal D O M D Cracks Amazon Top 500 60049 1 Dr Siegal 26apos 3Bs Cookie Diet Book by Obesity Expert Sanford Siegal D O M D Cracks Amazon Top 500 60049 2 Dr Siegal 26apos 3Bs Cookie Diet Book by Obesity Expert Sanford Siegal D O M D Cracks Amazon Top 500 60049 3 Dr Siegal 26apos 3Bs Cookie Diet Book by Obesity Expert Sanford Siegal D O M D Cracks Amazon Top 500 60049 4 Probiotic found to be effective treatment for colitis in mice 10518 1 Probiotic found to be effective treatment for colitis in mice 10518 2 Probiotic found to be effective treatment for colitis in mice 10518 3 IN Compass Health 26apos 3Bs Hospitalist Team at Morton Plant wins first BayCare Quality Award 60044 1 IN Compass Health 26apos 3Bs Hospitalist Team at Morton Plant wins first BayCare Quality Award 60044 2 IN Compass Health 26apos 3Bs Hospitalist Team at Morton Plant wins first BayCare Quality Award 60044 3

[0] Kent State University professors focus research on the environment with grants totaling $890,000 [1] A sticky solution for identifying effective probiotics [0] LSU gets to the bottom of things -- in Antarctica

(Date:11/25/2009)..., MARKHAM,ON,Nov.25/PRNewswire/-Cytochromatoday...fDirectors.Dr.MoldtwillreplaceMr.UlrikSporkastheNo...Boardmembersremainsunchangedatsixmembers. ,, "W...kforwardtobenefitingfromhisexperienceandguidanceas...gCKD-focusedspecialtypharmaceuticalcompany,"stated...

(Date:11/24/2009)..., HOUSTON,Nov.24/PRNewswire-FirstCall/--IES(Nas...dcommunicationssystemsandservicesforthecommercial,...itscommercialbusinessgrouphasbeenawardedacontractf...ortheLevel4bio-safetylab(BSL-4)replacementfacility...iseases(USAMRIID)atFortDetrickinFrederick,Md. ,...

(Date:11/24/2009)..., REYKJAVIK,Iceland,November24/PRNewswire-First...ouncedthatithasreceivednoticefrom,theNasdaqStockMa...pendedasofNovember30,2009andaForm25-NSEwillbefiled...emovedeCODE,scommonstock,fromlistingonNasdaq,unles...cationsPanel.Thecompanyhasfiledsuchanappeal,which,...

(Date:11/24/2009)..., SANMATEO,Calif.,Nov.24/PRNewswire-FirstCall/-...ompanyfocusedondevelopingandcommercializingnovelpa...onno,PresidentandChiefExecutiveOfficer,isscheduled...erence,tobeheldDecember1-2,2009atTheNewYorkPalaceH...higlieri,ChiefFinancialOfficer,willbeavailabletore...

Breaking Biology Technology:Cytochroma Announces Appointment of Peter Moldt to Board of Directors 2 Integrated Electrical Services Awarded Contract to Provide Electrical Systems for U.S. Army Medical Research Institute of Infectious Diseases 2 deCODE Receives Delisting Notice From Nasdaq, Plans to Appeal 2 deCODE Receives Delisting Notice From Nasdaq, Plans to Appeal 3 NeurogesX to Present at Piper Jaffray Health Care Conference 2 NeurogesX to Present at Piper Jaffray Health Care Conference 3

[0] Cytochroma Announces Appointment of Peter Moldt to Board of Directors [0] Integrated Electrical Services Awarded Contract to Provide Electrical Systems for U.S. Army Medical Research Institute of Infectious Diseases [0] deCODE Receives Delisting Notice From Nasdaq, Plans to Appeal [0] NeurogesX to Present at Piper Jaffray Health Care Conference

Other News:

...005 Columbia University Medical Center (CUMC) ann...he first phase of a multi-year campaign to build u...arch and lead the effort to fully realize the ther...on goal for the first stage of the campaign, $25 m...

..., researchers have found that nicotine triggers th...eroin their addictively rewarding properties--incl...eward. However, unlike opiates, nicotine does not ...t activates the natural opioid reward pathway in t...

La Jolla, Calif.- Nature is a seemingly endless storehouse of interesting - and potentially life-saving - biological molecules. But tracking down and harvesting those chemicals in their natural form

...stance combined with low-impact cardiovascular act...ple seeking to get into shape and stay healthy, ac...dy....... Ray Browning, a doctoral student in CU-B...d author on the new study, said the results show t...

Columbia University launches multi-year campaign to support stem cell research 2 Columbia University launches multi-year campaign to support stem cell research 3 Nicotine triggers the same brain reward circuitry as opiates 2 Promiscuous catalytic activity possessed by novel enzyme structure 2 Promiscuous catalytic activity possessed by novel enzyme structure 3 Walk slowly for weight loss, according to University of Colorado study 2 Walk slowly for weight loss, according to University of Colorado study 3

Columbia University launches multi-year campaign to support stem cell research Nicotine triggers the same brain reward circuitry as opiates Promiscuous catalytic activity possessed by novel enzyme structure Walk slowly for weight loss, according to University of Colorado study

...dissolver protein circulating in the.blood may be ...ding to a study.in this month's Stroke: Journal of...er, tissue plasminogen activator (TPA), is used as... produced naturally in the blood, keeps the.clotti...

...S. and Australian researchers have used.the eggshe...mans were probably.responsible for a major extinct...Australia's large animals. In the 8 January 1999 i...of Colorado and his colleagues report that the.ext...

...by Colorado State University ecologists.suggests t...ng season and.changes in prairie vegetation on the...ding states... Working at Colorado State's ...TER) station, the ecologists drew on 23 years of c...

...ecipher -- albeit scientifically -- just.what make...n University Medical.School researchers made a sta...AHC, which had been considered a possible female-s...y a prerequisite for male sexual development. .. ...

Elevated Blood Levels Of Inactive TPA Linked To Increased Stroke Risk In Young Women 2 Fossil Eggshells Hold Clues To Major Animal Extinctions As Reported In Science 2 Fossil Eggshells Hold Clues To Major Animal Extinctions As Reported In Science 3 Colorado State University Study Reveals Climate Change, Longer Growing Seasons Could Harm Grazing On Western Shortgrass Steppe 2 Colorado State University Study Reveals Climate Change, Longer Growing Seasons Could Harm Grazing On Western Shortgrass Steppe 3 Gene Once Thought To Program Ovarian Development Instead Found To Be Critical For Production Of Sperm 2

Elevated Blood Levels Of Inactive TPA Linked To Increased Stroke Risk In Young Women Fossil Eggshells Hold Clues To Major Animal Extinctions As Reported In ScienceColorado State University Study Reveals Climate Change, Longer Growing Seasons Could Harm Grazing On Western Shortgrass Steppe Gene Once Thought To Program Ovarian Development Instead Found To Be Critical For Production Of Sperm