HOME >> BIOLOGY >> NEWS
How movement lubricates bone joints

Taking a cue from machines that gently flex patients knees to help them recover faster from joint surgery, bioengineering researchers at UC San Diego have shown that sliding forces applied to cartilage surfaces prompt cells in that tissue to produce molecules that lubricate and protect joints.

The results reported in Osteoarthritis and Cartilage are important in the ongoing efforts of the group led by Robert Sah, a Howard Hughes Medical Institute (HHMI) professor at UCSDs Jacobs School of Engineering, to grow cartilage in the laboratory that can be used to replace patients injured or diseased joint surfaces.

We have shown that shear forces on cartilage prompt chondrocyte cells in it to produce proteoglycan 4, said Sah. This is an important step toward our goal of eventually growing joint tissue for transplantation.

Proteoglycan, a name that reflects its protein and polysaccharide components, is a basic building block of connective tissue throughout the body. The chondrocyte cells of cartilage make several forms of proteoglycans, including several that build up in cartilage and contribute to its stiffness. However, proteoglycan-4 is primarily secreted into the joint fluid where it coats and lubricates cartilage surfaces.

Unfortunately, the smooth surface of the articular cartilage at the ends of bones located at joints often deteriorates with aging, becoming increasingly roughened and eroded. Those joints become painful and progress to osteoarthritis. Surgeons can replace damaged and diseased joints with artificial joints, but they would like to be able to simply resurface patients existing joints with cartilage.

In a series of experiments, Sahs team attached bovine stifle joints, which are similar to human knee joints, to a bio-reactor that provided continuous irrigation with sterile nutritional fluids under normal physiological conditions. Immobile joints were compared to joints that were flexed 24 hours in
'"/>

Contact: Rex Graham
ragraham@ucsd.edu
858-822-3075
University of California - San Diego
5-Dec-2006


Page: 1 2

Related biology news :

1. St. Jude study yields secrets of chromosome movement
2. Cellular message movement captured on video
3. Information processing in the central nervous system: the signalling system controlling movement
4. Eye movement tasks can be used to assess fetal alcohol spectrum disorders
5. Electric fish shed light on ways the brain directs movement
6. Defective movement of cells power plants implicated in commom inherited neurological disorder
7. UNC scientists solve mystery of how largest cellular motor protein powers movement
8. 1st international study group for new movement discipline
9. Electronic chip, interacting with the brain, modifies pathways for controlling movement
10. Research links ecstasy to survival of key movement-related cells in brain
11. Magic marker monitors malicious movements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
(Date:3/30/2017)...  On April 6-7, 2017, Sequencing.com will host the ... hackathon at Microsoft,s headquarters in Redmond, Washington ... developing health and wellness apps that provide a unique, ... is the first hackathon for personal genomics and ... in the genomics, tech and health industries are sending ...
(Date:3/28/2017)... The report "Video Surveillance Market ... Storage Devices), Software (Video Analytics, VMS), and Service (VSaaS, ... to 2022", published by MarketsandMarkets, the market was valued ... to reach USD 75.64 Billion by 2022, at a ... year considered for the study is 2016 and the ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the ... million people each year. Especially those living in larger cities are affected by air ... one of the most pollution-affected countries globally - decided to take action. , “I ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that ... Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los ...
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced ... the NIH to develop RealSeq®-SC (Single Cell), expected to ... profiling small RNAs (including microRNAs) from single cells using ... highlights the need to accelerate development of approaches to ... "New techniques for measuring levels of ...
(Date:10/9/2017)... , ... October 09, 2017 , ... The award-winning American ... broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , ... faced with the challenge of how to continue to feed a growing nation. At ...
Breaking Biology Technology:
Cached News: