How the adrenal 'clock' keeps the body in synch

In mammals, including humans, a master clock in the brain and subordinate clocks found in organs throughout the body coordinate daily, or circadian, rhythms of behavior and physiology. Now, researchers reporting in the August Cell Metabolism, published by Cell Press, have elucidated the role of clocks of the adrenal glands in keeping those physiologic and metabolic rhythms in synchrony.

The adrenal glands sit atop each kidney, where they discharge steroid hormones known as corticoids--including the stress-related hormones adrenaline and cortisol. Corticoids influence stress response, metabolism, mineral balance, and reproduction.

In a study of mice, Henrik Oster of the Wellcome Trust Centre for Human Genetics at the University of Oxford, Gregor Eichele at the Max Planck Insitute of Biophysical Chemistry, and colleagues found that the adrenal clock acts as a "gate," shaping the amount of corticosterone--the mouse equivalent of cortisol--secreted in response to other hormonal cues driven by the body's master clock.

"The adrenal clock is of particular interest since adrenal corticoids have been implicated in the synchronization of subordinated clocks and were demonstrated to control metabolic rhythms in many other organs, including liver, kidney, and brain," Oster said. "We've identified a mechanism that bridges the gap between peripheral clock gene oscillations and the control of corticoid-dependent physiological rhythms in the adrenal gland and possibly in many other organs."

Oster's team found that the majority of clock genes exhibit a circadian pattern of activity in the adrenal. The clock genes were strongly expressed specifically in outer layers of the adrenal gland that are responsible for corticoid production. The findings offered "bona fide evidence" for the presence of a peripheral circadian clock in the adrenal glands.

To find out how the adrenal clock ticks, the researchers first treated slices of adrena

Contact: Heidi Hardman
Cell Press

Page: 1 2 3

Related biology news :

1. Targeting the adrenal gland could be key strategy against heart failure, Jefferson scientists show
2. Prenatal stress keeps infants, toddlers up at night, study says
3. Modified herpes virus keeps arteries free-flowing following procedures
4. A simple feedback resistor switch keeps latent HIV from awakening
5. To elude bats, a moth keeps its hearing in tune
6. Scientists identify synthetic compound that keeps stem cells young
7. Nerve cell software keeps track of brain change
8. How the brain keeps emotions at bay
9. Unusual mechanism keeps repair protein accurate
10. Friend protein keeps nerve signals in check
11. Chewing up a key regulator of fat synthesis keeps mice lean despite a high-fat diet

Post Your Comments:

(Date:8/21/2020)... , ... August 19, 2020 , ... ... premier conference and expo uniting life science, data science, informatics and IT leaders ... , “In this period of uncertainty and change, Bio-IT takes the leadership role ...
(Date:8/7/2020)... SAN FRANCISCO (PRWEB) , ... August 06, 2020 ... ... the life sciences industry, is pleased to announce that Eric Chen and Jessica ... Vice President of Product Management & Strategy, respectively. , Eric Chen heads development ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... II contract awarded by the Joint Science & Technology Office—Chemical and Biological Defense ... to develop, optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess suitable ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... (PRWEB) , ... July 16, 2020 , ... “We are ... Third Wave Bioactives. “It’s the only technology of its kind on the market and ... of onions with the protective capacity of traditional cultured ingredients, creating a natural way ...
(Date:7/18/2020)... ... 17, 2020 , ... dicentra , a leading Contract ... industries, is pleased to announce that Charles Galea has joined its clinical trials ... is an accomplished and results-driven sales executive with over 10 years of expertise ...
(Date:7/10/2020)... BALTIMORE (PRWEB) , ... July ... ... Baltimore biotechnology company, announced today that Massachusetts Institute of Technology (MIT) has ... This broader license allows PathSensors to move into the point-of-care diagnostic market, ...
(Date:7/10/2020)... ... 09, 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology ... R. Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. Nissenson will ... SBI-101. Dr. Nissenson serves as an Emeritus Professor of Medicine at the ...
Breaking Biology Technology:
Cached News: