HOME >> BIOLOGY >> NEWS
How the brain learns to become addicted

TA), known to be a critical site of neural adaptation, or plasticity, induced by addictive drugs. However, it wasn't known whether orexin actually induced such plasticity.

In experiments with rat brain slices, the researchers demonstrated that orexin A does increase activity of neurons in the VTA associated with such plasticity.

And in experiments with whole animals, the researchers found that orexin A was required for "behavioral sensitization" to cocaine. This sensitization shows itself as a long-lasting increase in activity by the animals when they receive the drug and is an indicator that the animals are experiencing an increased craving for the drug.

Importantly, when the researchers "microinjected" directly into the VTA region of animals a drug that blocks orexin receptors, they found they could block the development of behavioral sensitization.

"The findings presented here establish a potential mechanism for the role of orexin signaling in plasticity related to addiction," concluded the researchers. The researchers wrote that this orexin-induced plasticity in the VTA "is likely an important substrate of behaviors relevant to addiction, as we show that activation of [orexin] receptors in the VTA is necessary for the development of cocaine-mediated behavioral sensitization. Thus, orexin receptors may provide novel pharmacotherapeutic targets for motivational disorders such as addiction.


'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
15-Feb-2006


Page: 1 2

Related biology news :

1. Invasion of the brain tumors
2. Preclinical study links gene to brain aneurysm formation
3. Gene variant is associated with brain anatomy, clinical course of ADHD
4. Human knowledge is based upon directed connectivity between brain areas
5. A sensory organ, not the brain, differentiates male and female behavior in some mammals
6. Reading ability protects brain from lead exposure
7. Strength of connections between brain regions may affect an adolescents response to peer influence
8. Females more prone to brain damage from alcohol abuse
9. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
10. Drug protects brain cells in Huntingtons disease model, researchers find
11. Steroids, not songs, spur growth of brain regions in sparrows

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How the brain learns become addicted

(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Hand Geometry - Global Strategic Business Report" report ... markets for Hand Geometry in US$ Thousands. The report provides ... , Japan , Europe ... , and Rest of World. Annual estimates ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Iris Biometrics - Global Strategic Business Report" report ... markets for Iris Biometrics in US$ Thousands. The report provides ... , Japan , Europe ... , and Latin America . ...
(Date:3/18/2015)... , March 18, 2015 As mobile ... new revolutionary smart wallets and apps continue to be introduced ... entrenched in the mobile payment industry in focus today are:  ... Ltd. (NYSE: BABA ), Apple Inc. (NASDAQ: ... and Facebook Inc. (NASDAQ: FB ) ...
Breaking Biology News(10 mins):Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6
(Date:4/1/2015)... 2015 Synthetic Biologics, Inc. (NYSE MKT: ... infections and diseases, with a focus on protecting ... the development of SYN-004, the Company,s candidate therapy ... within the gastrointestinal (GI) tract and maintain the ... prevention of C. difficile infection, antibiotic-associated ...
(Date:4/1/2015)... (PRWEB) April 01, 2015 Earlier this ... a vibrant life sciences industry association that represents research-based ... members. , Jonathan Parker, AJO’s Vice President of ... Dinner in February, an event that attracted over 750 ... Don Wright, a 73 year old cancer survivor shared ...
(Date:3/31/2015)... VANCOUVER , March 31, 2015  /PRNewswire/ - ESSA Pharma ... that it has filed with the Food and Drug ... ("IND") application related to the Company,s proposed clinical trial ... IND application is required in order for ESSA to ... The IND application is a complete description ...
(Date:3/31/2015)... , March 31, 2015  Bayer HealthCare ... Institute of Massachusetts Institute of Technology (MIT) and ... discovery. The goal of this new part of ... genetics to help create new cardiovascular therapies. ... with the Broad Institute to the area of ...
Breaking Biology Technology:Synthetic Biologics' SYN-004 Clinical Data for Protection of Microbiome Selected for Poster Presentation at American Society of Microbiology 2015 2Synthetic Biologics' SYN-004 Clinical Data for Protection of Microbiome Selected for Poster Presentation at American Society of Microbiology 2015 3Synthetic Biologics' SYN-004 Clinical Data for Protection of Microbiome Selected for Poster Presentation at American Society of Microbiology 2015 4HR Consulting Firm, A.J. O'Connor Associates Joins BioNJ – The Vibrant 400 Member Strong Life Sciences Industry Association - and Attends its Annual Dinner 2ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 2ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 3ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 4Bayer HealthCare Expands Collaboration with Broad Institute of MIT and Harvard to Develop Therapies for Cardiovascular Disease 2Bayer HealthCare Expands Collaboration with Broad Institute of MIT and Harvard to Develop Therapies for Cardiovascular Disease 3
Cached News: