HOME >> BIOLOGY >> NEWS
How to steer a moving cell

Researchers at the University of California, San Diego (UCSD) School of Medicine have developed new technology which, combined with proteomics the large-scale study of the structure and function of proteins and their functions has allowed them to map an extensive network of the signaling proteins that control cell movement.

Their work, providing the first comprehensive profile of cell movement, could lead to a better understanding of cell migration in cancer metastasis and inflammatory disease. The study will be published the week of May 7-11 in the journal Proceedings of the National Academy of Sciences (PNAS).

Extra-cellular messengers called chemokines are families of small proteins secreted by cells that regulate the cells directional movement, or chemotaxis. Cells possess an innate ability to migrate, an inner compass that somehow senses the presence of chemokines. But in metastasis, the cells inner compass goes awry allowing cells to leave the primary tumor, crawl through tissues and enter blood vessels spreading the cancer throughout the body.

Richard Klemke, Ph.D., professor of pathology at UCSD School of Medicine and the Moores Cancer Center, and his colleagues set out to better understand the complexity of signaling mechanisms within the cell that become de-regulated and allow cells which are usually static to begin migrating.

The researchers hope to fully define the protein components of the compass to gain a better understanding of what directs cell migration or, in the case of cancer cells and inflammation, cause cells to migrate where they normally wouldnt.

"The ability to spatially organize specific groups of signaling proteins to the front or back of the cell is what drives cell polarization and directional movement," said Klemke. "It is the steering wheel of the cell." Now the researchers want to determine how the large numbers of signaling molecules that make up the compass are functi
'"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
7-May-2007


Page: 1 2 3

Related biology news :

1. Revolutionary new medical treatments: International effort to steer around obstacles
2. Latest strategies for moving research toward a cure for diabetes explored at global scientific forum
3. Removing a hydrogen fuel-cell roadblock
4. Freshwater snails are surprisingly fast-moving invaders
5. Removing DNA repair gene causes metabolic syndrome
6. Removing egg from nest may help save endangered whooping crane
7. Its a bugs life: MIT team tells moving tale
8. No trouble removing oil from water
9. Molecular motors cooperate in moving cellular cargo, study shows
10. Removing prions that cause mad cow in humans from blood

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How steer moving cell

(Date:2/25/2015)... 25, 2015  ABC Financial Services (ABC), the ... Health and Fitness Industry, today announced enhancements to ... The latest upgrade includes advances to the agreement ... check-in via Identity One fingerprint biometrics. The features ... interactive displays at the International Health, Racquet & ...
(Date:2/24/2015)... This report analyzes the worldwide markets for Iris ... for the US, Canada , ... Asia-Pacific , Middle East , and ... are provided for the period 2013 through 2020. Also, a ... and analytics are derived from primary and secondary research. Company ...
(Date:2/24/2015)... report analyzes the worldwide markets for Face and Voice Biometrics in ... The report provides separate comprehensive analytics for the US, ... , Asia-Pacific , Middle East ... Latin America . Annual estimates and forecasts are provided for ... provided for these markets. Market data and analytics are derived from ...
Breaking Biology News(10 mins):ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16
(Date:2/28/2015)... 2015 Increasing its efforts to resolve the ... first three episodes of The GMO TRUTH podcast on both ... as it continues its mission to discover the truth and ... phase, to “uncover the truth about the GMOs in our ... GMO Truth Podcast is an expansion of the documentary/investigative film-making ...
(Date:2/27/2015)... February 27, 2015 Immunovaccine Inc. (“Immunovaccine” ... of a fraudulent press release disseminated this morning by ... from Immunovaccine. This press release states that Immunovaccine has ... The press release did not originate from Immunovaccine ... within the press release. Please note that all ...
(Date:2/27/2015)... and SUMMERLAND, British Columbia ... (NYSE: XON ), a leader in synthetic ... to acquire  Okanagan Specialty Fruits (OSF), the pioneering ... , the world,s first non-browning apple. Through the acquisition, ... fruit that is more appetizing and convenient for consumers ...
(Date:2/27/2015)... SUNNYVALE, Calif. , Feb. 27, 2015 /PRNewswire/ ... announced that longer-term toxicology studies for its newly ... arthritis, or RA, have been completed. The results ... the U.S. Food and Drug Administration. The feedback ... completion of the ongoing first-in-human study. Additional preclinical ...
Breaking Biology Technology:The Walk a Mile Project Launches “GMO Truth” Podcast 2Immunovaccine Disclaims Hoax Press Release 2Intrexon to Acquire Okanagan Specialty Fruits 2Intrexon to Acquire Okanagan Specialty Fruits 3Intrexon to Acquire Okanagan Specialty Fruits 4Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 2Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 3
Cached News: