HOME >> BIOLOGY >> NEWS
How to steer a moving cell

Researchers at the University of California, San Diego (UCSD) School of Medicine have developed new technology which, combined with proteomics the large-scale study of the structure and function of proteins and their functions has allowed them to map an extensive network of the signaling proteins that control cell movement.

Their work, providing the first comprehensive profile of cell movement, could lead to a better understanding of cell migration in cancer metastasis and inflammatory disease. The study will be published the week of May 7-11 in the journal Proceedings of the National Academy of Sciences (PNAS).

Extra-cellular messengers called chemokines are families of small proteins secreted by cells that regulate the cells directional movement, or chemotaxis. Cells possess an innate ability to migrate, an inner compass that somehow senses the presence of chemokines. But in metastasis, the cells inner compass goes awry allowing cells to leave the primary tumor, crawl through tissues and enter blood vessels spreading the cancer throughout the body.

Richard Klemke, Ph.D., professor of pathology at UCSD School of Medicine and the Moores Cancer Center, and his colleagues set out to better understand the complexity of signaling mechanisms within the cell that become de-regulated and allow cells which are usually static to begin migrating.

The researchers hope to fully define the protein components of the compass to gain a better understanding of what directs cell migration or, in the case of cancer cells and inflammation, cause cells to migrate where they normally wouldnt.

"The ability to spatially organize specific groups of signaling proteins to the front or back of the cell is what drives cell polarization and directional movement," said Klemke. "It is the steering wheel of the cell." Now the researchers want to determine how the large numbers of signaling molecules that make up the compass are functi
'"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
7-May-2007


Page: 1 2 3

Related biology news :

1. Revolutionary new medical treatments: International effort to steer around obstacles
2. Latest strategies for moving research toward a cure for diabetes explored at global scientific forum
3. Removing a hydrogen fuel-cell roadblock
4. Freshwater snails are surprisingly fast-moving invaders
5. Removing DNA repair gene causes metabolic syndrome
6. Removing egg from nest may help save endangered whooping crane
7. Its a bugs life: MIT team tells moving tale
8. No trouble removing oil from water
9. Molecular motors cooperate in moving cellular cargo, study shows
10. Removing prions that cause mad cow in humans from blood

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How steer moving cell

(Date:8/3/2015)... , Aug. 3, 2015 Synaptics, Inc. ... interface solutions, today announced that members of the executive ... the Pacific Crest Global Technology Leadership Forum on Tuesday, ... conference will be held at the Sonnenalp Resort in ... The presentation may include forward-looking information. An audio webcast ...
(Date:7/31/2015)... 31 de julho de 2015 A 10 ... ) será realizada pela BGI de 22-25 de outubro de ... A conferência está celebrando seu 10 o. ... ICG se tornou uma das reuniões mais influentes do ... científicos mais dinâmicos, entusiastas e prazerosos. ...
(Date:7/31/2015)... China , 31. Juli 2015 Die 10. ... wird von BGI veranstaltet und findet vom 22. ... China , statt. Die ... Seit ihrem Start 2006 ist die ICG weltweit ... „omik" geworden. Sie ist eines der dynamischsten, enthusiastischsten ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3
(Date:8/4/2015)... ... August 04, 2015 , ... Graphite Metallizing ... process equipment, announces the appointment of Dennis Rawle as European Director of Sales. ... Most recently, he was General Manager and Technical Sales Manager for pump products ...
(Date:8/4/2015)... CAMBRIDGE, Mass. , Aug. 4, 2015  Blueprint ... and developing highly selective kinase drugs for genomically defined ... executive officer, will present a company overview at the ... 2015 at 1:20 p.m. EDT. A live ... the Investors section of the Blueprint Medicines website at ...
(Date:8/3/2015)... SAN DIEGO , Aug. 3, 2015  Halozyme ... Quarterly Update Conference Call for the second quarter 2015 ... p.m. PT. Dr. Helen Torley , president and ... same date post-market, Halozyme will release financial results for ... be webcast live through the "Investors" section of Halozyme,s ...
(Date:8/3/2015)... Aug. 3, 2015  Merck KGaA, Darmstadt, ... top-quality high-tech products in the healthcare, life science and ... company Nano-C, their development and launch of promising new ... (OPV). Merck KGaA, Darmstadt, Germany , ... OPV sector. Novel derivatives: highly stable, easy ...
Breaking Biology Technology:Dennis Rawle Joins Graphite Metallizing Corporation 2Halozyme to Host Second Quarter 2015 Financial Results Conference Call 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 3Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 4
Cached News: