HOME >> BIOLOGY >> NEWS
Human cells filmed instantly messaging for first time

Researchers at UCSD and UC Irvine have captured on video for the first time chemical signals that traverse human cells in response to tiny mechanical jabs, like waves spreading from pebbles tossed into a pond. The scientists released the videos and technical details that explain how the visualization effect was created as part of a paper published in the April 21 issue of Nature.

The researchers working at the UCSD Jacobs School of Engineering's Department of Bioengineering developed a novel molecular "reporter" system, which allowed the dynamic visualization of the activation of an important protein called Src. Peter Yingxiao Wang, lead author of the paper and a post-doctoral researcher in UCSD's Jacobs School of Engineering spent two years designing the reporter molecules to light up selectively only when Src was activated, and not other proteins.

Wang and his co-workers first demonstrated that the novel system was effective in visualizing Src activation in response to a known chemical stimulant, epidermal growth factor. Next, they studied the effect of mechanical stimuli on Src activation. Using technology developed at the Beckman Laser Institute at UC Irvine by its founding director Michael Berns, Wang and Elliott Botvinick, a postdoctoral researcher at UCSD Department of Bioengineering and the Beckman Laser Institute at UC Irvine, attached small, sticky beads to cells and gently tugged the beads to and fro with laser power acting as invisible "tweezers." As the laser tweezers moved the beads in one direction, a video camera attached to a specially equipped microscope recorded the dynamic movement of biochemical signals in the opposite direction in the form of a signature pattern of fluorescent light. The fine spatial and temporal resolution was made possible by a technology called fluorescence resonance energy transfer.

"We had no idea what to expect," said Wang. "The first time we saw these incredible waves spreading across the cells I
'"/>

Contact: Rex Graham
ragraham@ucsd.edu
858-822-3075
University of California - San Diego
20-Apr-2005


Page: 1 2 3

Related biology news :

1. Human knowledge is based upon directed connectivity between brain areas
2. Human-like altruism shown in chimpanzees
3. Human genetic deserts are teeming with significant life
4. Human activities increasing carbon sequestration in forests
5. Cell Press announces new partnership with the American Society of Human Genetics
6. Human ancestors learned to walk upright in the trees, say experts
7. Humans arent the only ones with obesity problems
8. Center for Science Writings debate: Redesigning Humanity, March 21
9. Human pubic lice acquired from gorillas gives evolutionary clues
10. GenePOPS -- Sequencing Human History: The Genetics and Commerce of Personal Ancestry
11. Human trial results show excellent safety data, from Geovaxs DNA/MVA AIDS vaccines

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2018)... ... August 23, 2018 , ... Clinical ... sensitivity and specificity over more commonly used analytical techniques. However, implementation can be ... of development and validation of methods that must be undertaken by the laboratory ...
(Date:8/23/2018)... ... August 21, 2018 , ... CRISPR-Cas9 ... cell types and species for the robust functional interrogation of complex biological processes. ... of T-cell based immunotherapies, the study of the autoimmunity, the understanding of host-pathogen ...
(Date:8/21/2018)... , ... August 20, 2018 ... ... advanced software solutions for biopharma R&D, today announced that Seattle-based Aptevo ... bioinformatics solution provider. Aptevo will use the Genedata Biologics ® platform ...
Breaking Biology News(10 mins):
(Date:9/15/2018)... , ... September 14, 2018 , ... Next-generation genomic sequencing ... even with new technologies, challenges remain. In the past, the sheer size of genomics ... Jude Cloud is a new data ecosystem developed to advance cures by reducing the ...
(Date:9/12/2018)... , ... September 11, 2018 , ... ... to add flat sheet Forward Osmosis (FO) membranes from Fluid Technology Solutions (FTS ... manufactured by FTS H2O are constructed from cellulose triacetate (CTA) material. The highly ...
(Date:9/7/2018)... ... September 06, 2018 , ... Flagship Biosciences’ ... been validated to be as effective as manual pathology. The study, “Validation of ... Muscle Biopsies,” was published in the Archives of Pathology & Laboratory Medicine on ...
(Date:8/29/2018)... ... 28, 2018 , ... Nanovis , an innovative and ... of a $5.5 million funding round managed by Commenda Securities. Key investors include ... Ellipsis Ventures. , “Our investment in Nanovis is consistent with our mission to ...
Breaking Biology Technology:
Cached News: