HOME >> BIOLOGY >> NEWS
Human cells filmed instantly messaging for first time

Researchers at UCSD and UC Irvine have captured on video for the first time chemical signals that traverse human cells in response to tiny mechanical jabs, like waves spreading from pebbles tossed into a pond. The scientists released the videos and technical details that explain how the visualization effect was created as part of a paper published in the April 21 issue of Nature.

The researchers working at the UCSD Jacobs School of Engineering's Department of Bioengineering developed a novel molecular "reporter" system, which allowed the dynamic visualization of the activation of an important protein called Src. Peter Yingxiao Wang, lead author of the paper and a post-doctoral researcher in UCSD's Jacobs School of Engineering spent two years designing the reporter molecules to light up selectively only when Src was activated, and not other proteins.

Wang and his co-workers first demonstrated that the novel system was effective in visualizing Src activation in response to a known chemical stimulant, epidermal growth factor. Next, they studied the effect of mechanical stimuli on Src activation. Using technology developed at the Beckman Laser Institute at UC Irvine by its founding director Michael Berns, Wang and Elliott Botvinick, a postdoctoral researcher at UCSD Department of Bioengineering and the Beckman Laser Institute at UC Irvine, attached small, sticky beads to cells and gently tugged the beads to and fro with laser power acting as invisible "tweezers." As the laser tweezers moved the beads in one direction, a video camera attached to a specially equipped microscope recorded the dynamic movement of biochemical signals in the opposite direction in the form of a signature pattern of fluorescent light. The fine spatial and temporal resolution was made possible by a technology called fluorescence resonance energy transfer.

"We had no idea what to expect," said Wang. "The first time we saw these incredible waves spreading across the cells I
'"/>

Contact: Rex Graham
ragraham@ucsd.edu
858-822-3075
University of California - San Diego
20-Apr-2005


Page: 1 2 3

Related biology news :

1. Human knowledge is based upon directed connectivity between brain areas
2. Human-like altruism shown in chimpanzees
3. Human genetic deserts are teeming with significant life
4. Human activities increasing carbon sequestration in forests
5. Cell Press announces new partnership with the American Society of Human Genetics
6. Human ancestors learned to walk upright in the trees, say experts
7. Humans arent the only ones with obesity problems
8. Center for Science Writings debate: Redesigning Humanity, March 21
9. Human pubic lice acquired from gorillas gives evolutionary clues
10. GenePOPS -- Sequencing Human History: The Genetics and Commerce of Personal Ancestry
11. Human trial results show excellent safety data, from Geovaxs DNA/MVA AIDS vaccines

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2019)... ... June 14, 2019 , ... Emtec, Inc.®, a ... a joint presentation with Versiti’s CIO at the Healthcare Industry User Group ... Creek Resort. , Versiti Vice President and Chief Information Officer, Lynne Briggs, will ...
(Date:6/13/2019)... ... ... KICVentures announced today its plans to host an event at Becker’s 17th ... Chicago on Thursday, June 13th at 6:30 pm. The event will take place at ... Ticino Hospitality room in space #74T. , The event will feature three brief talks ...
(Date:6/11/2019)... AUCKLAND, New Zealand (PRWEB) , ... June 12, ... ... a wide range of antibody discovery services, Abveris plans to leverage the Geneious ... , Dr. Colby Souders, Chief Technology Officer at Abveris, says: “The Geneious ...
Breaking Biology News(10 mins):
(Date:7/17/2019)... Va. (PRWEB) , ... July 16, 2019 , ... ... markers, according to a recent report from Kalorama Information. Abbott, Roche and Siemens ... reported in Kalorama Information’s latest report, Worldwide Market for Point-of-Care (POC) Diagnostics ...
(Date:7/9/2019)... ... , ... Today, at the BIO World Congress on Industrial Biotechnology ... announced the winners of the Consider Corn Challenge II. Three winners were chosen, each ... produce biobased materials. , “Corn is a sustainable, abundant and affordable industrial ...
(Date:7/2/2019)... ... 02, 2019 , ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma , ... The film focuses on regenerative veterinary medicine as a means of improving the ... included in the Brentwood and Pacific Palisades International Film Festival in Los Angeles, ...
(Date:6/18/2019)... ... June 17, 2019 , ... IVERIC bio, Inc. ... agreement for production and manufacturing of GMP-grade adeno-associated virus (AAV) vector for IVERIC ... retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment of BEST1 related retinal diseases. ...
Breaking Biology Technology:
Cached News: