HOME >> BIOLOGY >> NEWS
Human embryonic stem cells display a unique pattern of chemical modification to DNA

San Diego, Calif. -- Scientists from the Burnham Institute for Medical Research (BIMR) and Illumina Inc., in collaboration with stem cell researchers around the world, have found that the DNA of human embryonic stem cells is chemically modified in a characteristic, predictable pattern. This pattern distinguishes human embryonic stem cells from normal adult cells and cell lines, including cancer cells. The study, which appears online today in Genome Research, should help researchers understand how epigenetic factors contribute to self-renewal and developmental pluripotence, unique characteristics of human embryonic stem cells that may one day allow them to be used to replace diseased or damaged cells with healthy ones in a process called therapeutic cloning.

Embryonic stem cells are derived from embryos that are undergoing a period of intense cellular activity, including the chemical addition of methyl groups to specific DNA sequences in a process known as DNA methylation. The methylation and demethylation of particular DNA sequences in the genome are known to have profound effects on cellular behavior and differentiation. For example, DNA methylation is one of the critical epigenetic events leading to the inactivation of one X chromosome in female cells. Failure to establish a normal pattern of DNA methylation during embryogenesis can cause immunological deficiencies, mental retardation and other abnormalities such as Rett, Prader-Willi, Angelman and Beckwith-Wiedemann syndromes.

Until recently, DNA methylation could only be studied one gene at a time. But a new microarray-based technique developed at Illumina enabled the scientists conducting this new study to simultaneously examine hundreds of potential methylation sites, thereby revealing global patterns. "Analyzing the DNA methylation pattern of hundreds of genes at a time opens a new window for epigenetic research," says Dr. Jian-Bing Fan, director of molecular biolog
'"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
4-Aug-2006


Page: 1 2

Related biology news :

1. Human knowledge is based upon directed connectivity between brain areas
2. Human-like altruism shown in chimpanzees
3. Human genetic deserts are teeming with significant life
4. Human activities increasing carbon sequestration in forests
5. Cell Press announces new partnership with the American Society of Human Genetics
6. Human ancestors learned to walk upright in the trees, say experts
7. Humans arent the only ones with obesity problems
8. Center for Science Writings debate: Redesigning Humanity, March 21
9. Human pubic lice acquired from gorillas gives evolutionary clues
10. GenePOPS -- Sequencing Human History: The Genetics and Commerce of Personal Ancestry
11. Human trial results show excellent safety data, from Geovaxs DNA/MVA AIDS vaccines

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... 22, 2020 , ... The field of quantitation of large molecules or proteins ... this area. However, the use of mass spectrometry in this field has gained a ... “How do you choose which approach to use (LBA or MS)?” In many ...
(Date:6/23/2020)... ... 23, 2020 , ... In its June 22 online post, business and technology ... Sherley, M.D., Ph.D., founder and director of stem cell biotechnology company Asymmetrex . ... that starting July 5 it would begin offering free tissue stem cell ...
(Date:6/19/2020)... , ... June 18, 2020 ... ... webinar series, “Automate Your Lab with Software for Data Decisions,” for pharmaceutical ... learn how to integrate and automate cutting-edge scientific instruments and laboratory equipment ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... ... 2020 , ... Join experts from Reed Tech , Gary Saner, Sr. ... one hour live webinar on Thursday, August 13, 2020 at 11am EDT ... medical devices. Specifically, for medical devices, the NMPA has departments dealing with medical device ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, ... of laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines ... Bode-CARES provides a turnkey solution that includes a comprehensive collection and ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World has announced ... Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, and the ... awards program, highlighting outstanding examples of how technology innovations and strategic initiatives can ...
(Date:6/28/2020)... , ... June 25, 2020 , ... ... racing to develop a vaccine or drug treatment. In an effort to better ... has publicly released the world’s largest imaging dataset portraying therapeutic compound effects from ...
Breaking Biology Technology:
Cached News: