HOME >> BIOLOGY >> NEWS
Huntington's disease study shows animal models on target

This release is available in French.

An international team of researchers has published a benchmark study showing that gene expression in several animal models of Huntingtons Disease (HD) closely resembles that of human HD patients.

The results, published August 1, 2007, in the journal Human Molecular Genetics, validate the applicability of using animal models to study human disease and will have important consequences for the pertinence of these models in preclinical drug testing.

Huntington's disease is an incurable and fatal hereditary neurodegenerative disorder caused by a mutation in the gene that encodes the huntingtin protein. Neurons in certain regions of the brain succumb to the effects of the altered protein, leading to severe motor, psychiatric, and cognitive decline. Several recent studies have shown that the mutant huntingtin protein modifies the transcriptional activity of genes in affected neurons. This disease mechanism is a promising new avenue for research into the causes of neuronal death and a novel potential approach for treatment.

Led by EPFL professor Ruth Luthi-Carter, and involving collaborators from six countries, the current study found a marked resemblance between the molecular etiology of neurons in animal models and neurons in patients with HD. This implies that animal models are relevant for studying human HD and testing potential treatments.

To come to this conclusion, the scientists measured the gene expression profile of seven different transgenic mouse models of HD, representing different conditions and disease stages. These profiles clarified the role of different forms and dosages of the protein hungtintin in the transcriptional activity of neurons. They then designed and implemented novel computational methods for quantifying similarities between RNA profiles that would allow for comparisons
'"/>

Contact: Alexandre Kuhn
alexandre.kuhn@epfl.ch
41-216-931-731
Ecole Polytechnique Fdrale de Lausanne
31-Jul-2007


Page: 1 2

Related biology news :

1. Drug protects brain cells in Huntingtons disease model, researchers find
2. Better sleep may put Huntingtons disease sufferers back on track
3. Subtle signs can help predict Huntingtons disease early
4. Landmark study identifies large number of new proteins implicated in Huntingtons disease
5. Study links faulty DNA repair to Huntingtons disease onset
6. Proteasome activator enhances survival of Huntingtons disease neuronal model cells
7. Test reveals effectiveness of potential Huntingtons disease drugs
8. Metabolic disorder underlies Huntingtons disease
9. Unique Huntingtons study moves forward
10. Gene therapy injected into the brains of mice with Huntingtons disease
11. Research suggests cause of neurodegeneration in Huntingtons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/12/2019)... ... November 12, 2019 , ... ... from nonprofit U.S. universities and research institutions for its Instrumentation Grant for ... up to $1.2 million per site for the acquisition of instrumentation, development and ...
(Date:11/7/2019)... (PRWEB) , ... November 07, 2019 , ... R3 Stem ... 50% off through the rest of 2019. The code to use during checkout is ... well. , R3 is the nation’s leader in regenerative therapies with over 12,000 successful ...
(Date:11/5/2019)... ... November 05, 2019 , ... Dr. Lauren Kopp ... dentistry to Seattle, WA, including porcelain veneers , smile makeovers, dental implants, ... University of Washington, Dr. Kopp is passionate about serving her Seattle community with ...
Breaking Biology News(10 mins):
(Date:11/5/2019)... ... November 05, 2019 , ... Focal Healthcare ... Mark for its Fusion Bx 2.0 prostate fusion biopsy solution. By combining information ... Bx 2.0 will give urologists across Europe the ability to perform targeted transrectal ...
(Date:11/2/2019)... ... 2019 , ... A clinical trial usually involves many different ... principal investigators, supply chain managers, manufacturers, IRT, CRAs and so on. Lack of ... data, potentially leading to patient risk. , By having a single source of ...
(Date:11/2/2019)... (PRWEB) , ... October 31, 2019 , ... ... released by pharma artificial intelligence pioneer tellic. drug360 brings tellic’s expertise in ... new tool allows researchers to quickly uncover relationships between genes, diseases, variants, phenotypes, ...
(Date:10/30/2019)... ... October 30, 2019 , ... Western University of ... innovation and technology play in educating the next generation of health care providers. ... and presentations by WesternU administrators and representatives of companies working with the University ...
Breaking Biology Technology:
Cached News: