HOME >> BIOLOGY >> NEWS
Huntington's disease study shows animal models on target

This release is available in French.

An international team of researchers has published a benchmark study showing that gene expression in several animal models of Huntingtons Disease (HD) closely resembles that of human HD patients.

The results, published August 1, 2007, in the journal Human Molecular Genetics, validate the applicability of using animal models to study human disease and will have important consequences for the pertinence of these models in preclinical drug testing.

Huntington's disease is an incurable and fatal hereditary neurodegenerative disorder caused by a mutation in the gene that encodes the huntingtin protein. Neurons in certain regions of the brain succumb to the effects of the altered protein, leading to severe motor, psychiatric, and cognitive decline. Several recent studies have shown that the mutant huntingtin protein modifies the transcriptional activity of genes in affected neurons. This disease mechanism is a promising new avenue for research into the causes of neuronal death and a novel potential approach for treatment.

Led by EPFL professor Ruth Luthi-Carter, and involving collaborators from six countries, the current study found a marked resemblance between the molecular etiology of neurons in animal models and neurons in patients with HD. This implies that animal models are relevant for studying human HD and testing potential treatments.

To come to this conclusion, the scientists measured the gene expression profile of seven different transgenic mouse models of HD, representing different conditions and disease stages. These profiles clarified the role of different forms and dosages of the protein hungtintin in the transcriptional activity of neurons. They then designed and implemented novel computational methods for quantifying similarities between RNA profiles that would allow for comparisons
'"/>

Contact: Alexandre Kuhn
alexandre.kuhn@epfl.ch
41-216-931-731
Ecole Polytechnique Fdrale de Lausanne
31-Jul-2007


Page: 1 2

Related biology news :

1. Drug protects brain cells in Huntingtons disease model, researchers find
2. Better sleep may put Huntingtons disease sufferers back on track
3. Subtle signs can help predict Huntingtons disease early
4. Landmark study identifies large number of new proteins implicated in Huntingtons disease
5. Study links faulty DNA repair to Huntingtons disease onset
6. Proteasome activator enhances survival of Huntingtons disease neuronal model cells
7. Test reveals effectiveness of potential Huntingtons disease drugs
8. Metabolic disorder underlies Huntingtons disease
9. Unique Huntingtons study moves forward
10. Gene therapy injected into the brains of mice with Huntingtons disease
11. Research suggests cause of neurodegeneration in Huntingtons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2020)... (PRWEB) , ... February 11, 2020 , ... ... moved into The LaunchPort™ medical device accelerator in Port Covington, Baltimore. The newly ... issues that must be addressed to manage increased demand for home dialysis treatments. ...
(Date:2/7/2020)... ... February 07, 2020 , ... dicentra , ... health product, nutraceutical and dietary supplement industries, announces 2020 membership with the International ... expertise and research pertaining to probiotics. We are thrilled to join our IPA ...
(Date:2/6/2020)... ... February 06, 2020 , ... Kerafast Inc. , developers ... today announced an agreement with The Good Food Institute , a nonprofit ... the partnership, terrestrial meat and aquatic cell lines will be made available to ...
Breaking Biology News(10 mins):
(Date:2/3/2020)... ... February 03, 2020 , ... Global molecular ... that OmniType, the 11-locus, single tube multiplex successor to Holotype HLA is available ... featuring locus-multiplexing and short library preparation, for HLA genotyping from sample to answer ...
(Date:1/28/2020)... ... January 28, 2020 , ... Today, Salimetrics announced an addition ... Salivary Total Human IgG Assay Kit exemplifies Salimetrics’ 20+ year commitment ... can extend the accuracy and ease of use of salivary bioscience into infectious ...
(Date:1/24/2020)... ... January 24, 2020 , ... The plastic and reconstructive surgeons at The ... epitomize the notion that plastic surgery is much more than just cosmetic surgery and ... Over the last 20 years NJ Top Docs, Dr. Andrew Elkwood, Dr. Michael Rose, ...
(Date:1/23/2020)... ... 22, 2020 , ... Ideal Implant CEO and President Robert ... recent North American investor forums specializing in medical advancements. New technology was presented ... Forum on November 21, 2019 in New York City, and the Aesthetic Technology ...
Breaking Biology Technology:
Cached News: