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'I had them a moment ago, now where are my glasses?'

mulus in their working memory ("memory phase"), and compare that information to the second stimulus and make a decision based on the comparison (the "decision phase").

At the outset of the study, Brody and Cold Spring Harbor Laboratory postdoctoral fellow Christian Machens hoped to develop a mathematical model--based on known properties of "spiking" neurons--that would explain how the brain carries out just the memory phase of the behavior.

To their surprise, the simple "mutual inhibition" model they developed yielded a neural network architecture that explains not only the memory phase, but also the loading phase and the decision phase of the behavior. The model makes several predictions about the neurological basis of working memory that can be tested to confirm the likelihood that the model is a significant advance toward understanding fundamental properties of brain structure and function.


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Contact: Peter Sherwood
sherwood@cshl.edu
516-367-6947
Cold Spring Harbor Laboratory
17-Feb-2005


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