ISN's Nexus Hypertension-Kidney debate

The Infinite Gain: three decades on

Delivering the Opening Plenary Lecture, John E. Hall, Guyton Professor, Chairman of Physiology and Biophysics and Director of the Center of Excellence in Cardiovascular -Renal Research (University of Mississippi Medical Center), will present on Renal-Pressure Natriuresis - An Infinite Gain Feedback Mechanism fo Long-Term Blood Pressure Regulation"

The Nexus Plenaries to follow will aim to map the relevance of Guyton's pioneering work in both present and future contexts, spanning a wide range of timely and related topics:

Genomics: Hap Map Project (Aravinda Chakravarti, USA), Proteomics of Renal Exosomes (Mark Knepper, USA), Epidemiology: the Developmental Origins of Adult Disease (David JP Barker, UK), and Circadian control of genes, cells, and organs (Ueli Schibler, Switzerland).

Biomarkers, regultators and risk factors

In alignment with the unique Nexus format, the core program will incorporate three sessions dedicated to both the bench and the 'bedside' levels. Promoting a highly multidisciplnary approach, Hypertension and the Kidney will offer it series of three parallel sessions to deliver the cutting edge basic and clinical discovery aimed at researchers, physicians and clnicians respectively. Mirrored at both levels, the Baisc Science and Clinical Sessions will offer in-depth, rigorous updates on and around RAAS and Cardiovascular Risk, Proteinuria and Hypertension and Diuretics Revisited.

The translational sessions: the jewel in the Nexus crown

The three Translational Sessions - the key and final phase in closing the bench to bedside gap - are naturally offered to all participants. Set to signpost future directions and concrete solutions in research, patient treatment and care - the ultimate step toward addressing real day to day clinical challenges. These sessions will tackle: Guyton's Concept in 2007, Salt-Regulation Effec

Contact: Amanda Wren
International Society of Nephrology

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