HOME >> BIOLOGY >> NEWS
Identified main genetic variants involved in response to HIV

This release is also available in Spanish.

This international collaboration has been the largest ever to have taken place in a large scale study on genetic differences between patients infected by HIV, and is the first study of this kind in the field of infectious disease. Catalan participants have been coordinated by Javier Martnez-Picado, ICREA research professor in the Foundation irsiCaixa of Hospital Germans Trias i Pujol, and Josep M. Mir, consultant of the Unit of Infectious Diseases and AIDS of Hospital Clnic-IDIBAPS of Barcelona, and had the collaboration of Hospital de la Santa Creu i Sant Pau, and Hospital Mtua de Terrassa.

Research has been conducted with the latest genomics and bioinformatics technologies, analysing 550,000 variations of the complete human genome in 486 patients, mostly European, preselected from 30,000 potential candidates.

These variations, known as simple nucleotide polymorphisms (SNPs), are single variations affecting only one nucleotide or base of the genomic sequence. Despite humans sharing 99.9% of the genome sequence, there are still 3 million genetic variations which make us different from one another 90% of which are due to SNPs. Hence, a good knowledge of these variations is highly valuable for the determination of the progression of AIDS.

During the present study, obtained genetic data was compared to blood virus load in patients during the first two years after the infection, and also to the rhythm of immune degradation as a result of the infection. This type of comparison, known as association study, permitted to deduct main genetic variations playing a central role in the control of viral infection.

Results point to two gene variants related to the immune system. More precisely, these variations are in a genetic region responsible for the determination of immune response capacity again
'"/>

Contact: lex Argem
aargemi@clinic.ub.es
34-932-275-700
IDIBAPS - Institut d'Investigacions Biomdiques August Pi i Sunyer
20-Jul-2007


Page: 1 2

Related biology news :

1. Identified mechanism in the malaria parasite to help it adapt to infected individuals
2. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
3. Does the desire to consume alcohol and tobacco come from our genetic makeup?
4. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
7. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
8. Discoverer of Sly Syndrome finds way of delivering medicine to fight rare genetic disorder
9. Restless legs genetics on the move
10. UK scientists lift lid on genetics of coronary artery disease
11. Global community listens to TAU genetic researcher at EU Conference on Hearing Loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2020)... ... 2020 , ... GIOSTAR/HEAMGEN has developed and secured ... The red blood cells are made utilizing a bioreactor that permits the production ... replaces the need for a human blood donor. GIOSTAR/HEAMGEN mature red ...
(Date:1/22/2020)... ... January 21, 2020 , ... Astro Pak’s ... new Business Development Department. The move, which is part of the company’s structural ... as the company’s Senior Vice President where he oversaw its Cleanroom Division as ...
(Date:1/22/2020)... , ... January 21, 2020 ... ... in integrating cold chain operations, developing transport validation strategies, supporting global regulatory ... both Inc. 5000 and the Houston Business Journal as a fastest growing ...
Breaking Biology News(10 mins):
(Date:2/3/2020)... ... February 03, 2020 , ... ... Firm Travel, Law Firm Travel, Technology Industry Travel and Biotech/Healthcare Industry Travel Indexes. ... Each Index illustrates the following statistics:, Average airfare ...
(Date:1/27/2020)... ... 27, 2020 , ... Cerebyte, the leader in “instant mentoring” ... announced the availability of neuroscience of transformational leadership workshops. These highly interactive, hands-on ... leadership and change research to become great transformational leaders. The workshops ...
(Date:1/23/2020)... ... January 22, 2020 , ... ... the cosmetic surgery industry at two recent North American investor forums specializing in ... Canaccord Genuity Medical Technologies & Diagnostics Forum on November 21, 2019 in New ...
(Date:1/10/2020)... ... January 09, 2020 , ... ... Development establishes benchmarks for the vendor qualification process, a critical element of ... process volume and complexity of the vendor qualification process creates delays in initiation ...
Breaking Biology Technology:
Cached News: