The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
Identifying the mechanism behind a genetic susceptibility to type 2 diabetes

Identifying the mechanism behind a genetic susceptibility to type 2 diabetes

Type 2 diabetes is reaching epidemic proportions in the developed world. Determining if and how certain genes predispose individuals to type 2 diabetes is likely to lead to the development of new treatment strategies for individuals with the disease.

In a study appearing in the August issue of the Journal of Clinical Investigation Valeriya Lyssenko and colleagues from Lund University in Sweden show that certain variants of the gene TCF7L2 make individuals more susceptible to type 2 diabetes. The susceptibility variants were associated with increased expression of TCF7L2 in pancreatic islet cells and decreased islet cell secretion of insulin. Consistent with this, ectopic overexpression of TCF7L2 in human islet cells decreased insulin secretion in response to exposure to glucose. This study identifies TCF7L2 type 2 diabetes susceptibility variants and provides a mechanism by which these genetic variants might cause susceptibility to the disease. As discussed by the authors and in the accompanying commentary by Andrew Hattersley from Peninsula Medical School in the United Kingdom, future studies are likely to investigate the potential for manipulating the signaling pathways controlled by TCF7L2 for the development of new therapeutics for type 2 diabetes.


'"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
1-Aug-2007


Page: 1

Related biology news :

1. Identifying the nuclear in nuclear medicine as high benefit
2. Identifying Piwis partners
3. Contagious obesity? Identifying the human adenoviruses that may make us fat
4. Identifying the signatures of protons in water
5. Identifying blood stem cells is a SLAM dunk
6. Identifying the path to infection
7. Identifying genes that contribute to a low level of response to alcohol
8. Weizmann Institute scientists discover a control mechanism for metastasis
9. New mechanism links smoking to lung damage
10. Identified mechanism in the malaria parasite to help it adapt to infected individuals
11. A new plant-bacterial symbiotic mechanism promising

Post Your Comments:
(Date:11/4/2009)...he Singapore laboratory that deciphered the DNA co... and elephant shark, has joined The Genome 10K Pro...le repository of DNA sequences on 10,000 species o...scale that currently can not be achieved. , Part...a paper published in the Nov. 5, 2009 issue of the...
(Date:11/4/2009)..., REDWOOD CITY, Calif., Oct. 20 D...ity and authentication solutions, today announced ...-of-sale (POS) software for quick-service restaura... their NextGen POS and Classic POS solutions. WAND... biometrics to boost cashier accountability and de...
(Date:11/4/2009)..., WALL, N.J., Oct. 26 B...YI), a leader in finger-based biometric identifica...tity solutions at the AABB TXPO conference being h...ber 25-27 2009. BIO-key will provide hands-on prod...ication technology in booth #424. Also, at 5 PM on...
Breaking Biology News(10 mins):Singapore scientists join international study of 10,000 vertebrates' genomes 2WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 2WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 3BIO-key(R) International Exhibiting at AABB TXPO 2Hologic to Present at Citis 2009 Sixth Annual Small Mid Cap Conference 5609 1B Braun and Amerinet Sign to Expand Infusion Therapy Offerings 5606 1B Braun and Amerinet Sign to Expand Infusion Therapy Offerings 5606 2B Braun and Amerinet Sign to Expand Infusion Therapy Offerings 5606 3Logical Therapeutics to Present Data on LT NS001 at American College of Gastroenterology Annual Meeting 5603 1Logical Therapeutics to Present Data on LT NS001 at American College of Gastroenterology Annual Meeting 5603 2
(Date:11/5/2009)..., LYNBROOK, N.Y., Nov. 5 /PRNewswire-FirstCall/ ...), a biopharmaceutical company developing first-in... its financial results for the third quarter ended...py that, in September of this year, the FDA,s Arth...by a vote of 12-0, the approval of XIAFLEX(TM) for...
(Date:11/5/2009)..., SAN DIEGO, CA, November 5, 2009 /PRNewswire-Fi...any focused on using proprietary taste receptor-ba...nts for the food, beverage, and ingredient supply ...reported financial results for the third quarter e...on for the third quarter of 2009, compared to $4.0...
(Date:11/5/2009)..., PLYMOUTH MEETING, Pa., Nov. 5 /PRNewswire-...q: BJGP ) ("BMP Sunstone" or the "Company") today... quarter 2009 financial results on,Monday, Novembe... Company will hold a conference call at 5:00 pm ET... results. Listeners may access the call by,dialin...
(Date:11/5/2009)... Brooke Sanders brings a ne...ine, CA (PRWEB) November 5, 2009 -- Professional R...g reprographics company is pleased to present Broo...y as their graphics/PR specialist. The addition of...nsistent growth within Professional Reprographics....
Breaking Biology Technology:BioSpecifics Technologies Corp. Reports Third Quarter 2009 Financial Results 2BioSpecifics Technologies Corp. Reports Third Quarter 2009 Financial Results 3BioSpecifics Technologies Corp. Reports Third Quarter 2009 Financial Results 4BioSpecifics Technologies Corp. Reports Third Quarter 2009 Financial Results 5SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS 14BMP Sunstone to Report Third Quarter 2009 Financial Results 2
Other News:
...l Challenges...An Earth System Science Partnership...006, Beijing, China...www.essp.org/essp2006...Conf...entre (BICC)...No. 8 Beichendong Rd, Chaoyang Dist...dex.htm...From the Amazon to Monsoon Asia to sub-S...
...nsect Molecular Biology, today publishes its Honey...the release of the long-awaited Honey Bee Genome S...azine. ... The Honey Bee Genome Sequencing Project...e United States Department of Agriculture and the ...
...wn that targeted overexpression of heat shock prot...ry glands, a common consequence of treatment for h...al., "Radioprotective effect of HSP25 on submandib...e of The American Journal of Pathology. ... Patien...
It's all about "the birds and the bees." And now, "the silkworm moths and the fruit flies."...A chemical ecologist and a genetics researcher at the University of California, Davis, have joined forces
Open Science Conference to focus on regional sustainability challenges to the Earth system 2Open Science Conference to focus on regional sustainability challenges to the Earth system 3Open Science Conference to focus on regional sustainability challenges to the Earth system 4Open Science Conference to focus on regional sustainability challenges to the Earth system 5Open Science Conference to focus on regional sustainability challenges to the Earth system 6Looking to a new era in bee research 2Saving salivary glands from the collateral damage of radiation therapy 2UC Davis scientists' groundbreaking research: Mate-attracting chemicals 2UC Davis scientists' groundbreaking research: Mate-attracting chemicals 3
...atory, scientists have successfully.transplanted t... and arrested.the course of a debilitating congeni...s and still some years from clinical application,....grown from scratch can be used.to repair defective...
...due University have shown in.preliminary findings ....industries could be reduced by more than 40 perce... research is part of an effort to help companies c...issions of styrene, a chemical compound used to.ma...
...lk to each other, they come.equipped with their ow...d with.proteins called transporters that act as mo...eleased chemical messengers...Transporters are cri...ey are.targets for both therapeutic drugs and drug...
...tial to the nation's well-being and.economic growt...ional Science.Board (NSB), the policy-making body ...erim report, Environmental Science and Engineering...ience Foundation, discusses the need for the U.S. ...
Transplant cells show capacity for mending nervous system 2Transplant cells show capacity for mending nervous system 3Purdue helps Indiana companies with pollution dilemma 2Purdue helps Indiana companies with pollution dilemma 3Scientists uncover molecular changes underlying amphetamine and antidepressant action 2Scientists uncover molecular changes underlying amphetamine and antidepressant action 3National Science Board calls for significant new investment in research on the environment 2