HOME >> BIOLOGY >> NEWS
Image of myosin-actin interaction revealed in cover story of Molecular Cell

(September 29, 2005, La Jolla, CA) Scientists from the Burnham Institute for Medical Research and the University of Vermont have captured the first 3-dimensional (3D) atomic-resolution images of the motor protein myosin V as it "walks" along other proteins, revealing new structural insights that advance the current model of protein motility and muscle contraction. The culmination of four years of work, this collaboration among biochemists and structural biologists was selected as the cover story for the September issue of the scientific journal Molecular Cell.

The Burnham team, led by Dorit Hanein, Ph.D., was the first to reveal the 3D representation of myosin V "walking" along actin filament, a key protein involved in motility and muscle contraction. Using electron-cryo microscopy to take 3D snapshots of myosin V and actin interacting, researchers were able to see myosin V moving along the actin substrate in a "natural state." Previous 2D models have been based on staining or other treatment of the myosin that might alter the complex's natural mechanism of action.

Myosins are a large family of motor proteins that interact with actin filaments for motor movement and muscle contraction. Myosin V is the workhorse of the myosin protein family. It exists to ferry a cargo of proteins needed in a specific place at a specific time. Fueled by hydrolysis -- the process of converting the molecule adenosine triphosphate (ATP) into energy -- myosin V travels in one direction using actin as a track to deliver its payload of cell vesicles and organelles. Myosin V is also involved in transporting proteins that signal and communicate with other cells.

Myosin V has a two-chained "tail" that diverges to form two "heads" that bind to specific grooves on actin and walk hand over hand along the track, similar to the way a child moves along the monkey bars in a playground. Myosin V differs from the other myosin family proteins in that it is able to sustain
'"/>

Contact: Nancy Beddingfield
nbeddingfield@burnham.org
858-646-3146
Burnham Institute
29-Sep-2005


Page: 1 2 3

Related biology news :

1. 2007 Image of the Year: Molecular imaging relates human brain chemistry to aggressive behavior
2. Depiction of findings selected as 2007 Image of the Year by Society for Nuclear Medicine
3. Images develop clinical applications for new DESI technology
4. Beyond blur: Image quality shapes eye growth, but limited criteria apply
5. Imaging goes 3-D: exquisite PET/CT image captures SNMs 2005 Image of the Year
6. Protein interactions targets for Huntington disease therapy
7. Elastic interactions of membrane proteins
8. Scientists discover rare gene-for-gene interaction that helps bacteria kill their host
9. Penn leads $4 million grant to study gene-environment interactions in lung cancer
10. Microtubule protein interactions visualized en masse
11. Screening for complex genetic interactions

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... CHICAGO (PRWEB) , ... July 09, 2020 , ... Today ... Umami Advantage, which will share insight on the “fifth taste” phenomenon that is revolutionizing ... snacks. The Umami Advantage will be live on Monday, July 13, 2020 at11:00 AM ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, ... glioblastoma—the most common and aggressive adult brain cancer—announced today the appointments of its ... are charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows ...
(Date:6/23/2020)... MILTON KEYNES, England (PRWEB) , ... June 23, ... ... operations in Africa supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and ... rapid response project to support testing operations in the fight against the COVID-19 ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... CHARLOTTE, N.C. (PRWEB) , ... June 29, 2020 ... ... has reported year to date growth of 40% in 2020, despite many obstacles ... medical technology, MedShift aims to increase revenue for its partnered medical practices and ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... insights, today announced that the launch of a new clinical diagnostics ... about the tumor microenvironment (TME). , “Flagship’s TissueInsight is a service that ...
(Date:6/28/2020)... (PRWEB) , ... June 25, 2020 , ... ... are racing to develop a vaccine or drug treatment. In an effort to ... has publicly released the world’s largest imaging dataset portraying therapeutic compound effects ...
(Date:6/28/2020)... ... June 26, 2020 , ... ... solutions providers, today announced its strong opposition to the recently introduced bicameral ... a blanket ban on most federal use of nearly all biometric and related ...
Breaking Biology Technology:
Cached News: