HOME >> BIOLOGY >> NEWS
Imaging study links key genetic risk for Alzheimer's disease to myelin breakdown

A new UCLA imaging study shows that age-related breakdown of myelin, the fatty insulation coating the brain's internal wiring, correlates strongly with the presence of a key genetic risk factor for Alzheimer disease.

The findings are detailed in the January edition of the peer-reviewed journal Archives of General Psychiatry and add to a growing body of evidence that myelin breakdown is a key contributor to the onset of Alzheimer disease later in life.

In addition, the study demonstrates how genetic testing coupled with non-invasive evaluation of myelin breakdown through magnetic resonance imaging (MRI) may prove useful in assessing treatments for preventing the disease.

"Myelination, a process uniquely built up in humans, arguably is the most important and most vulnerable process of brain development as we mature and age. These new findings offer, for the first time, compelling genetic evidence that myelin breakdown underlies both the advanced age and the principal genetic risks for Alzheimer disease," said Dr. George Bartzokis, professor of neurology at UCLA's David Geffen School of Medicine.

"The human brain functions as a high-speed Internet system," said Bartzokis, director of the UCLA Memory Disorders and Alzheimer Disease Clinic and Clinical Core director of the UCLA Alzheimer Disease Research Center. "The quality of the brain's connections is key to its speed, bandwidth, fidelity and overall on-line capability."

Myelin is a sheet of lipid, or fat, with very high cholesterol content -- the highest of any brain tissue. The high cholesterol content allows myelin to wrap tightly around axons, speeding messages through the brain by insulating these neural "wire" connections.

As the brain continues to develop in adulthood and as myelin is produced in greater and greater quantities, cholesterol levels in the brain increase and eventually promote the production of a toxic protein that attacks the brain. The protein atta
'"/>

Contact: Dan Page
dpage@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
2-Jan-2006


Page: 1 2

Related biology news :

1. FSU leads botanical research into 21st century: Deep South Plant Specimen Imaging Project
2. ESA POLinSAR 2007 -- Imaging forests in 3-D
3. Imaging techniques permit scientists to follow a day -- or 4 -- in the life of a cell
4. Imaging pinpoints brain regions that see the future
5. Brookhaven Lab and Mount Sinai form joint Center for Translational Biomedical Imaging
6. Imaging single molecules opens new way to study gene expression, protein production
7. SNM awards $25,000 Mallinckrodt Seed Grant in Molecular Imaging/Nuclear Medicine Research
8. Society of Nuclear Medicine announces collaborative working agreement with Bio-Imaging Technologies
9. Imaging goes 3-D: exquisite PET/CT image captures SNMs 2005 Image of the Year
10. New study warns limited carbon market puts 20 percent of tropical forest at risk
11. Clones on task serve greater good, evolutionary study shows

Post Your Comments:
(Date:2/5/2015)... PARK, N.C. , Feb. 5, 2015  Marken ... specialist logistics company and has launched a new marketing ... Clinical Logistics Organization (CLO).  The new campaign focuses on ... on patient, protocol and shipments. The first ... , aligns Marken,s priorities with its client,s priorities. ...
(Date:2/5/2015)... January 28, 2015 New Market ... And Segment Forecasts To 2020 has Been Added to ... market is expected to reach USD 5.10 billion by ... Research, Inc. IR cameras help identify the site of ... to witness surging demand in medical imaging applications. They ...
(Date:2/5/2015)... 3, 2015 Despite a lack of ... such as consumer electronics, automotive, storage and telecommunication ... technology (SMT) screen printers. Innovations in electronics and ... push the adoption curve up. Meanwhile, sale volumes ... glue dispensers are indispensable in the production of ...
Breaking Biology News(10 mins):Marken Launches New Patient-Centric Campaign 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 3End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 2End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 3
(Date:3/3/2015)... , March 3, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: ... sustainable chemicals, today announced it has initiated commissioning activities ... in Sarnia, Ontario , Canada.  ... approximately five months, with the facility being in commercial ... be completed in two months and it is carrying ...
(Date:3/3/2015)... FL (PRWEB) March 03, 2015 ... company’s growing faculty. Camacho Alcocer, a biomedical researcher and ... Mexico, will join GSCG’s team of biomedical professors who ... Engineering” program. , Criogenix SA de CV is a ... and Technological Institutions and Companies in Mexico (RENIECYT). , ...
(Date:3/2/2015)... PA (PRWEB) March 02, 2015 The ... ReachMD announced today the launch of ... to educate healthcare professionals on the application of human ... The series features peer-to-peer interviews conducted during the ASHG ... ,     Translational Genomics and Health Outcomes Research: What's ...
(Date:3/2/2015)... NY (PRWEB) March 02, 2015 In ... Services industry has experienced robust growth. The industry, ... products, industrial materials, energy resources and other goods, has ... rising government regulation. As a result, IBISWorld forecasts that ... 2.8% to reach $946.8 million over the five-year period, ...
Breaking Biology Technology:BioAmber Begins Commissioning of Sarnia Commercial Plant 2BioAmber Begins Commissioning of Sarnia Commercial Plant 3Mario Camacho Alcocer Joins Global Stem Cells Group Faculty 2Mario Camacho Alcocer Joins Global Stem Cells Group Faculty 3American Society of Human Genetics (ASHG) and ReachMD Launch Series on Genetics and Genomics 2American Society of Human Genetics (ASHG) and ReachMD Launch Series on Genetics and Genomics 3Laboratory Testing Services in Canada Industry Market Research Report Now Available from IBISWorld 2Laboratory Testing Services in Canada Industry Market Research Report Now Available from IBISWorld 3
Cached News: