HOME >> BIOLOGY >> NEWS
Immune cells become potent cancer killers after genetic redirection

Scientists have made significant progress towards understanding how the immune system can be more specifically and efficiently targeted against cancer cells. The research, published in the January issue of Immunity, may provide the basis for development of a new, extensive immunotherapy for human tumors.

Normal cells that have transformed into cancer cells produce and display large amounts of proteins called tumor- and leukemia-associated antigens (TAA). Although immune cells recognize TAAs it has been difficult to develop immunotherapies for humans based on these interactions, in part because many normal cells and tissues produce small amounts of TAAs and the body has a certain amount of self-tolerance that prevents a vigorous immune attack.

Dr. Matthias Theobald from Johannes Gutenburg-University in Mainz, Germany, and colleagues used sophisticated genetic techniques to circumvent this self-tolerance and essentially redirect key human immune cells. Specifically, the researchers focused on the p53 tumor suppressor protein that is mutated in the majority of human cancers. Immune self-tolerance to p53 exists because of low levels of wild-type p53 that are expressed by normal cells.

The researchers used special mice genetically engineered that lack the normal action of CD8 cells required for development of self-tolerance to generate an immune cell receptor (TCR) specific for tumor-associated p53. The gene for this receptor was then transferred to human immune cells and resulted in redirected CD4+ Th and CTL immune cells that aggressively attacked tumor cells.

According to Dr. Theobald, "Our study on the intentional redirection of human CD4+ Th cells and high-avidity CD8 CTL by the delivery of genes encoding a single CD8-independent, high-affinity p53A2.1-specific TCR lays the foundation for the exploitation of this approach for a novel, broad-spectrum immunotherapy of malignant disease."


'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
25-Jan-2005


Page: 1

Related biology news :

1. Immune system escape hatch gives cancer cells traction
2. Immune antibodies penetrate neurons to clear Alzheimers-linked amyloid
3. Immune response to cancer stem cells may dictate cancers course
4. Immune systems in breast cancer survivors who suffer from fatigue fail to shut off after therapy
5. Immune response to HIV in the brain
6. Immune substances may help antibody-based drugs fight cancer
7. Immune cell receptors act in combination to regulate attack
8. Immune system has evolved to prevent autoimmune disease
9. Immune cells known as macrophages linked to growth of lymph vessels in eyes, scientists discover
10. Immune systems distress signal tells bacteria when to strike back
11. Immune cells genetic jam session is controlled by cell division machinery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2019)... ... January 31, 2019 , ... Through its ... research support in study design, planning, sample collection, and analysis to researchers at ... Gynecology, and Dr. Sara Vaughn, MD, Reproductive Endocrinology and Infertility Fellow, to study ...
(Date:2/2/2019)... ... February 01, 2019 , ... uBiome, the leader in ... A2LA, which establishes requirements for medical laboratories to demonstrate competence to deliver timely, ... as well as College of American Pathologists (CAP)-accredited, a designation given to the ...
(Date:1/25/2019)... FRANCISCO (PRWEB) , ... January 24, 2019 , ... ... of Dr. Julia Oh, PhD, Assistant Professor of Microbiology at the Jackson Laboratory ... doctors from around the world, Dr. Oh will bring to uBiome expertise in ...
Breaking Biology News(10 mins):
(Date:1/21/2019)... ... 21, 2019 , ... Microbial Discovery Group (MDG), a leading ... institutional cleaning market. MDG’s SporActiv liquid and powder product line contains safe ingredients ... control, floor and tile cleaners, carpets, drains, portable restroom cleaning and more. ...
(Date:1/20/2019)... ... January 17, 2019 , ... Consumers ... the exclusive purview of physicians. That's changing as many services now exist for ... (DTC) laboratory testing market totaled $208 million in 2018, according to Kalorama Information’s ...
(Date:1/20/2019)... ... January 17, 2019 , ... ... Partner announces the launch of a specialized automation technology, titled Automate 3D. Automate ... automatic generation of models and drawings to deliver to end-users, customers, and ERP ...
(Date:1/15/2019)... (PRWEB) , ... January 15, 2019 , ... Personalized treatment ... for worsening kidney disease, according to a new study published in the journal Radiology. ... are frequently treated with partial nephrectomy, a surgical procedure in which the tumor and ...
Breaking Biology Technology:
Cached News: