HOME >> BIOLOGY >> NEWS
Immune system 'escape hatch' gives cancer cells traction

Scientists at Johns Hopkins and elsewhere say they have mapped out an escape route that cancers use to evade the bodys immune system, allowing the disease to spread unchecked.

In a report published in the July 1 issue of the journal Nature Medicine, the Hopkins team, along with researchers from Florida and Nebraska, describe how myeloid-derived suppressor cells (MDSCs), which normally keep the immune system in check and prevent it from attacking otherwise healthy tissue, can suppress the anti-tumor response to cancer.

These suppressor cells block other immune system cells, CD8 killer T cells, from binding with proteins that identify the foreign antigens on the surface of unhealthy cancer cells, marking them for destruction, the team reports.

The good news, they say, is that their experiments also suggest that the chain reactions in T-cell tolerance are reversible, raising the possibility of vaccine and drug therapies that break through the blocked immune system.

Previous research had confirmed that MDSCs, produced in the bone marrow, were attracted to tumors, but until now, scientists had not identified exactly how the cells inhibit the immune systems ability to mount an attack.

By explaining some of the precise biological workings of MDSCs in cancer the teams findings suggest why experimental cancer vaccines have to date been plagued by T-cell tolerance, a weakened rather than strengthened immune response, says Jonathan Schneck, M.D., Ph.D., one of the studys authors.

Our findings also open up a new door in drug and vaccine development that we never knew existed and provide another opportunity for drug development into autoimmune diseases, where the immune system is in overdrive and needs to be slowed down, says Schneck, a professor of medicine, pathology and oncology at The Johns Hopkins University School of Medicine and its Kimmel Cancer Center.

The teams latest report built on
'"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
16-Jul-2007


Page: 1 2 3

Related biology news :

1. Immune antibodies penetrate neurons to clear Alzheimers-linked amyloid
2. Immune response to cancer stem cells may dictate cancers course
3. Immune systems in breast cancer survivors who suffer from fatigue fail to shut off after therapy
4. Immune response to HIV in the brain
5. Immune substances may help antibody-based drugs fight cancer
6. Immune cell receptors act in combination to regulate attack
7. Immune system has evolved to prevent autoimmune disease
8. Immune cells known as macrophages linked to growth of lymph vessels in eyes, scientists discover
9. Immune systems distress signal tells bacteria when to strike back
10. Immune cells genetic jam session is controlled by cell division machinery
11. Immune systems initial response to cancer under study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/26/2019)... (PRWEB) , ... March 26, 2019 , ... ... proud to introduce the four recipients of the Society's 2019 Outstanding Achievement Award, ... four awards will be presented at the ASGCT 22nd Annual Meeting . ...
(Date:3/25/2019)... ... March 25, 2019 , ... Abcam, ... research organisation focused on advancing drug discovery, have announced a collaboration to develop ... clearing methods, which are essential to get a better view of complex structures ...
(Date:3/18/2019)... ... March 18, 2019 , ... Periodontal disease, where bacterial infection of ... 50% of the US population. Making this disease particularly challenging to treat is ... the cells are enmeshed in a sticky extracellular material that makes them more resistant ...
Breaking Biology News(10 mins):
(Date:4/9/2019)... ... April 09, 2019 , ... Sonny Bar Lisa, or Sonny for ... approximately two months. After a series of diagnostics, an MRI was performed which ... Alison, researched the injury and found that VetStem Regenerative Cell Therapy may ...
(Date:4/8/2019)... , ... April 08, 2019 , ... US Capital ... a $15 million preferred equity investment in the privately held pharmaceutical company, S1 Biopharma ... drug, Lorexys, is targeted at female hypoactive sexual dysfunction disorder and is ready to ...
(Date:4/4/2019)... BOSTON (PRWEB) , ... April 03, 2019 , ... ... leaders together through intimate off-the-record collaboration and dialogue, today announces its Boston CEO ... CEO offers insights into the industry’s challenges and opportunities with high-level panels and ...
(Date:3/27/2019)... ... March 27, 2019 , ... In honor of National Nutrition Month, Lajollacooks4u ... of healthy meals and good nutrition. This month, Chef Jodi Abel appeared on ... , The first segment addressed the nutritional value of USDA’s MyPlate, a ...
Breaking Biology Technology:
Cached News: