HOME >> BIOLOGY >> NEWS
Immune system 'escape hatch' gives cancer cells traction

research initially conducted at the University of South Florida, where researchers analyzed blood samples and lymph tissue from healthy mice injected with MDSCs and found that T-cell levels remained the same, indicating that MDSCs did not destroy the immune response but apparently altered how the T cells behaved.

Using chemical tests in which individual tumor cells can be tagged with a fluorescent dye that allows them to glow when they are not bound to T cells, Florida researchers measured the immune response in mice to various foreign proteins, with and without injections of MDSCs. They found an 80 percent suppression of the immune response in the presence of MDSCs, confirming that the suppressor cells were inactivating the T cells.

The Florida team then turned to Schneck, who in 1993 developed several novel proteins to test how various antigens, such as those on cancer cells, specifically latch on to T cells.

Researchers then began experiments to determine if the MDSC T-cell interference was simply genetic or had some biochemical explanation, testing a half-dozen major reactions known to occur during infection to see if any set path was particularly active during interference.

In tissue tests from tumor-filled mice bred to lack a biochemical reaction, the scientists found that one specific pathway, the reactive-oxygen species, or ROS pathway, stood out, because when inactivated, T-cell tolerance did not develop. Researchers were surprised when subsequent tests showed that ROS actually modified the T cells, altering their structure so they could no longer bind to tumor-cell antigens.

When a known byproduct of ROS, the chemical peroxynitriate, was neutralized, T-cell tolerance failed to develop in test tube studies, pinning down peroxynitrate as the culprit prohibiting immune cell binding to and marking of foreign tumor cells.

Peroxynitrate activity is the escape hatch, and now that we have identif
'"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
16-Jul-2007


Page: 1 2 3

Related biology news :

1. Immune antibodies penetrate neurons to clear Alzheimers-linked amyloid
2. Immune response to cancer stem cells may dictate cancers course
3. Immune systems in breast cancer survivors who suffer from fatigue fail to shut off after therapy
4. Immune response to HIV in the brain
5. Immune substances may help antibody-based drugs fight cancer
6. Immune cell receptors act in combination to regulate attack
7. Immune system has evolved to prevent autoimmune disease
8. Immune cells known as macrophages linked to growth of lymph vessels in eyes, scientists discover
9. Immune systems distress signal tells bacteria when to strike back
10. Immune cells genetic jam session is controlled by cell division machinery
11. Immune systems initial response to cancer under study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... April 18, 2017  Socionext Inc., a global expert in SoC-based ... edge server, the M820, which features the company,s hybrid codec technology. ... by Tera Probe, Inc., will be showcased during the upcoming Medtec ... show at the Las Vegas Convention Center ... Click here ...
(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... July 18, 2017 , ... Recently recognized ... https://dataformsoftware.com ) announces the migration of its flagship cloud-based product Planet Life Cycle ... team-centric, enterprise work management system that merges strategic and financial planning with execution. ...
(Date:7/17/2017)... ... July 17, 2017 , ... ... solutions, today announced safety software company AB Cube has joined its ... segment to advance technology innovation across life sciences and healthcare. Under the ...
(Date:7/17/2017)... ... 17, 2017 , ... Panitch Schwarze Belisario & Nadel ... BiG (Biomedical Innovation Group) annual meeting in China. , This year’s meeting, held ... T-cell) therapy, a rapidly developing highly personalized anti-cancer technology that involves removing some ...
(Date:7/16/2017)... ... July 16, 2017 , ... ... analytical instruments announced the launch of its new line of Rocking and Waving ... and waving shaker models (both analog and digital) for laboratory applications in a ...
Breaking Biology Technology:
Cached News: