HOME >> BIOLOGY >> NEWS
Immune system's distress signal tells bacteria when to strike back

The human opportunistic pathogen, Pseudomonas aeruginosa, has broken the immune system's code, report researchers from the University of Chicago, enabling the bacteria to recognize when its host is most vulnerable and to launch an attack before the weakened host can muster its defenses.

In the 29 July 2005 issue of Science, the researchers show how this lethal organism detects interferon-gamma, a chemical messenger the immune system uses to coordinate its efforts to get rid of bacteria. When these bacteria intercept this message, they recognize it as a threat, assess their own numbers and, if they have sufficient strength, activate genes that quickly transform them from benign passengers in the bowel into deadly blood-stream invaders.

"Most of the time these microbes are content to live and grow in our intestines," said John Alverdy, M.D., professor of surgery at the University of Chicago and director of the study. "They don't feel the need or even look for the opportunity to attack. But when they detect a threat, they have a remarkably sophisticated defense plan, based, unfortunately, on the notion that the best defense is an overwhelming offense."

Pseudomonas aeruginosa is ubiquitous. It lives in all sorts of moist places, including damp soil and on the surface of vegetables, as well as in streams, faucets and drinking fountains. It is often a long-term bowel tenant, colonizing the intestines of about three percent of healthy people.

In the bowel this germ is usually harmless, but it can turn deadly, causing gut-derived sepsis. It is also a frequent cause of infections after major surgery.

Physicians have theorized, said Alverdy, that germs such as Pseudomonas are always "probing for a weakness in the host and are ready and willing to strike whenever they find one." He and his colleagues, however, are testing an alternative theory: that "bacteria are perfectly content in their niche until signals from the
'"/>

Contact: John Easton
John.Easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
28-Jul-2005


Page: 1 2 3

Related biology news :

1. Immune system escape hatch gives cancer cells traction
2. Immune antibodies penetrate neurons to clear Alzheimers-linked amyloid
3. Immune response to cancer stem cells may dictate cancers course
4. Immune systems in breast cancer survivors who suffer from fatigue fail to shut off after therapy
5. Immune response to HIV in the brain
6. Immune substances may help antibody-based drugs fight cancer
7. Immune cell receptors act in combination to regulate attack
8. Immune system has evolved to prevent autoimmune disease
9. Immune cells known as macrophages linked to growth of lymph vessels in eyes, scientists discover
10. Immune cells genetic jam session is controlled by cell division machinery
11. Immune systems initial response to cancer under study

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Immune system distress signal tells bacteria when strike back

(Date:2/5/2015)... SAN DIEGO , Jan. 26, 2015   Epic ... treatment of cancer, today announced that Murali Prahalad , ... Personalized Medicine World Conference (PMWC) 2015: Silicon Valley, ... Mountain View, Calif. on January 26-28, ... entitled, "CTCs Come of Age as Biomarkers." Last year, Epic ...
(Date:2/5/2015)... 28, 2015 Research and Markets ... the "Global Biometrics Market (2014-2020): Market Forecast ... report to their offering. , ... is anticipated to overtake ... increasing government spending towards IT security, government biometric ...
(Date:1/22/2015)... /PRNewswire/ - Today, FindBiometrics, the leading source of biometrics industry news, ... website design. "When we launched FindBiometrics 12 years ... O,Neill , founder and CEO of FindBiometrics. "Now it,s maturing ... the key players on a very broad scale.  We are ...
Breaking Biology News(10 mins):Epic Sciences to Present at Personalized Medicine World Conference 2015 on the Use of Circulating Tumor Cells as Cancer Biomarkers 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 3Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2
(Date:2/27/2015)... 2015  Steep Hill, the industry leader in cannabis ... to open a full service medical cannabis quality assurance ... bringing advanced scientific tools and methodology to the state, ... is currently the only laboratory licensed by the New ... testing in order to meet the recently adopted regulatory ...
(Date:2/26/2015)... Feb. 26, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" ... sciences company that develops and commercializes proprietary technologies and ... and operational results for the fiscal first quarter ended ... are in Canadian dollars (CAD), unless otherwise stated. ... win new business from our existing customers and add ...
(Date:2/26/2015)... February 26, 2015 The Movement for ... to support life extension technologies and awareness. The event ... Coordinated Time, on March 21st 2015, in a live ... , Eric Schulke, Founder of MILE, says, “Our lives ... urgency. The Movement for Indefinite Life Extension is raising ...
(Date:2/26/2015)... 2015 The Pittcon 2015 Exposition, ... Ernest N. Morial Convention Center in New Orleans, ... February 19, 2015) displaying products and services used ... government labs. The Exposition will offer the latest ... to, analytical chemistry; drug discovery; nanotechnology; life sciences ...
Breaking Biology Technology:Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 2SQI Diagnostics Reports First Quarter Financial Results 2SQI Diagnostics Reports First Quarter Financial Results 3SQI Diagnostics Reports First Quarter Financial Results 4SQI Diagnostics Reports First Quarter Financial Results 5SQI Diagnostics Reports First Quarter Financial Results 6Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3Pittcon 2015 Announces Exposition Highlights 2
Cached News: