HOME >> BIOLOGY >> NEWS
Immune system's distress signal tells bacteria when to strike back

The human opportunistic pathogen, Pseudomonas aeruginosa, has broken the immune system's code, report researchers from the University of Chicago, enabling the bacteria to recognize when its host is most vulnerable and to launch an attack before the weakened host can muster its defenses.

In the 29 July 2005 issue of Science, the researchers show how this lethal organism detects interferon-gamma, a chemical messenger the immune system uses to coordinate its efforts to get rid of bacteria. When these bacteria intercept this message, they recognize it as a threat, assess their own numbers and, if they have sufficient strength, activate genes that quickly transform them from benign passengers in the bowel into deadly blood-stream invaders.

"Most of the time these microbes are content to live and grow in our intestines," said John Alverdy, M.D., professor of surgery at the University of Chicago and director of the study. "They don't feel the need or even look for the opportunity to attack. But when they detect a threat, they have a remarkably sophisticated defense plan, based, unfortunately, on the notion that the best defense is an overwhelming offense."

Pseudomonas aeruginosa is ubiquitous. It lives in all sorts of moist places, including damp soil and on the surface of vegetables, as well as in streams, faucets and drinking fountains. It is often a long-term bowel tenant, colonizing the intestines of about three percent of healthy people.

In the bowel this germ is usually harmless, but it can turn deadly, causing gut-derived sepsis. It is also a frequent cause of infections after major surgery.

Physicians have theorized, said Alverdy, that germs such as Pseudomonas are always "probing for a weakness in the host and are ready and willing to strike whenever they find one." He and his colleagues, however, are testing an alternative theory: that "bacteria are perfectly content in their niche until signals from the
'"/>

Contact: John Easton
John.Easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
28-Jul-2005


Page: 1 2 3

Related biology news :

1. Immune system escape hatch gives cancer cells traction
2. Immune antibodies penetrate neurons to clear Alzheimers-linked amyloid
3. Immune response to cancer stem cells may dictate cancers course
4. Immune systems in breast cancer survivors who suffer from fatigue fail to shut off after therapy
5. Immune response to HIV in the brain
6. Immune substances may help antibody-based drugs fight cancer
7. Immune cell receptors act in combination to regulate attack
8. Immune system has evolved to prevent autoimmune disease
9. Immune cells known as macrophages linked to growth of lymph vessels in eyes, scientists discover
10. Immune cells genetic jam session is controlled by cell division machinery
11. Immune systems initial response to cancer under study

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Immune system distress signal tells bacteria when strike back

(Date:8/22/2014)... CAEveryone,s heard of the birds and the bees. ... that are being fertilized. The fertilization process for ... communication between the male and female reproductive cells. ... Regensburg, Heidelberg, and Munich, and including Carnegie,s Wolf ... in the chemical signaling process that guides flowering ...
(Date:8/21/2014)... SHELTON, Conn. , Aug. 21, 2014 ... on the growing mobile commerce market, announced today that ... purchase common stock to be issued in its proposed ... been approved for listing on The Nasdaq Capital Market, ... of the common stock and warrants, and will trade ...
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- LiveScan ... has agreed to a partnership with Gabriel Health ... fastest growing Certified Nursing Assistant preparatory ... Institute  an exclusive member of Binary,s LiveScan service ... Biometrics will improve its service capabilities by ...
Breaking Biology News(10 mins):Calcium and reproduction go together 2Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 3
(Date:8/22/2014)... DUBLIN , Aug. 22, 2014 ... the "Global Molecular Biology Enzymes, Kits, & Reagents ... to 2018" report to their offering. ... at $2,847.63 million in 2013, and is expected to ... million in 2018. Molecular biology enzymes, kits, & reagents ...
(Date:8/22/2014)... Greenville, SC (PRWEB) August 22, 2014 ... that indisputable acknowledgement is a national disgrace. Furthermore, ... part in establishing the current, deplorable state of ... outlined "5 great mistakes," to merely serve as ... convey the extent of colossal failure(s) that have ...
(Date:8/21/2014)... research team including DESY scientists has observed tiny quantum ... reports in the journal Science that the ... the nanodroplets. It is the first time that the ... samples of what is known as superfluid helium, have ... best expectations," says Andrey Vilesov of the University of ...
(Date:8/21/2014)... 21, 2014 Telomere Biosciences, LLC (Telomere ... "TELO-20 for Dogs" with Telomerase Activation Complex ... the world for dogs. Telomeres are the protective ... the body. A wealth of ground-breaking research by ... Science and Aging, including Nobel laureates, has demonstrated ...
Breaking Biology Technology:Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 35 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Scientists observe quantum vortices in cold helium droplets 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3
Cached News: