HOME >> BIOLOGY >> NEWS
Imprinting disorders and ART world's largest study results are reassuring

Further confirmation of a link between 'imprinting' disorders and assisted reproduction techniques (ART) was provided to the 21st annual conference of the European Society of Human Reproduction and Embryology today (Tuesday 21 June 2005). Dr. Alastair Sutcliffe, from the Department of Child Health, University College, London, UK, was reporting the results of the world's largest study into the relation between ART and four disorders known to be associated with aberrant genomic imprinting patterns.

Genetic imprinting is a mechanism in which gene expression depends upon parental origin. Mutations can alter normal imprinting, thus causing genetic abnormalities. Beckwith-Widermann syndrome (BWS) , Transient Neonatal Diabetes (TND), and Angelman syndrome (AS) and Prader-Willi syndrome (PWS) are all acquired because of either a maternal or paternal deletion on a chromosome or from inheritance of both chromosomes of a pair from one parent.

"It has been known for some time that BWS, for example, was associated with ART", said Dr. Sutcliffe, "and we set out to look at the association of all four disorders and assisted conception." Dr. Sutcliffe and his team contacted patients throughout the UK who were in support groups for the disorders and obtained family histories and details of whether or not they had had ART, and if so, which kind. Out of 82 replies from families who had had a child with BWS, 10 had used ART in order to conceive (12%). Families with children with TND, AS, and PWS were also contacted and asked the same questions.

"We found that BWS was the only disorder where there was a significant risk for children conceived by ART", said Dr. Sutcliffe. "However, we found that all affected children apart from those with BWS had a mixture of genomic mutations, whereas those with BWS had a suggested mechanism maternal loss of methylation". Methylation is a mechanism used to inactivate parts of a chromosome to prevent problems.
'"/>

Contact: Mary Rice
mary@mrcommunication.org
European Society for Human Reproduction and Embryology
20-Jun-2005


Page: 1 2

Related biology news :

1. New strategy for treating allergic disorders
2. A new method of adult stem cell growth efficacious in treatment of disorders of the cornea
3. Double identities lie behind chromosome disorders
4. Study finds regions of DNA that appear linked to autistic spectrum disorders
5. Scientists find new agent to fight genetic disorders -- Zorro-Locked Nucleic Acid
6. Generalist genes linked to a variety of learning disorders
7. Eye movement tasks can be used to assess fetal alcohol spectrum disorders
8. Scientists uncover potential key to brain blood-flow disorders
9. Genetic mechanism helps explain chronic pain disorders
10. NIH launches Health Info Rx Program on newborn screening and related genetic disorders
11. Blame myelin for many neuropsychiatric disorders

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/28/2016)... 2016 "The biometric system ... The biometric system market is in the growth ... near future. The biometric system market is expected to ... a CAGR of 16.79% between 2016 and 2022. Government ... technology in smartphones, rising use of biometric technology in ...
(Date:11/22/2016)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, is pleased to announce that the company has ... Sciences Awards as "Most Outstanding in eClinical Solutions" ... of recognition and growth for MedNet, which has effectively ... iMedNet ™ , MedNet,s flagship eClinical ...
(Date:11/17/2016)... , Nov. 17, 2016 Global Market Watch: ... Biobanks (Disease-Based Banks, Population-Based Banks and Academics) market is to ... for Private Biobanks shows the highest Compounded Annual Growth Rate ... region during the analysis period 2014-2020. North ... of 9.95% followed by Europe at ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... , Nov. 30, 2016  GenomOncology today announced the ... President of Medical Affairs.  Dr. Coleman will ... the company,s proprietary knowledge-enabled platform. The GenomOncology software suite empowers ... genetic sequencing data and clinical decision support, from quality control ... , ...
(Date:11/30/2016)... - Portage Biotech Inc. ("Portage" or "the Company") (OTC: ... announce the formation of EyGen, Ltd. a new ... through proof of concept. EyGen,s lead asset is ... Limited and being developed for topical ophthalmic delivery ... diseases. This agent has the potential to become ...
(Date:11/30/2016)... 2016  The Allen Institute for Cell Science ... publicly available collection of gene edited, fluorescently tagged ... cellular structures with unprecedented clarity. Distributed through the ... are a crucial first step toward visualizing the ... makes human cells healthy and what goes wrong ...
(Date:11/30/2016)... Nov. 30, 2016  Tempus, a technology company ... and Penn,s Abramson Cancer Center have partnered to ... response to immunotherapy treatment based on next generation ... part of a research collaboration, Tempus will provide ... cancer patient data to Penn. Utilizing next-generation sequencing, ...
Breaking Biology Technology:
Cached News: