HOME >> BIOLOGY >> NEWS
Imprinting disorders and ART world's largest study results are reassuring

Further confirmation of a link between 'imprinting' disorders and assisted reproduction techniques (ART) was provided to the 21st annual conference of the European Society of Human Reproduction and Embryology today (Tuesday 21 June 2005). Dr. Alastair Sutcliffe, from the Department of Child Health, University College, London, UK, was reporting the results of the world's largest study into the relation between ART and four disorders known to be associated with aberrant genomic imprinting patterns.

Genetic imprinting is a mechanism in which gene expression depends upon parental origin. Mutations can alter normal imprinting, thus causing genetic abnormalities. Beckwith-Widermann syndrome (BWS) , Transient Neonatal Diabetes (TND), and Angelman syndrome (AS) and Prader-Willi syndrome (PWS) are all acquired because of either a maternal or paternal deletion on a chromosome or from inheritance of both chromosomes of a pair from one parent.

"It has been known for some time that BWS, for example, was associated with ART", said Dr. Sutcliffe, "and we set out to look at the association of all four disorders and assisted conception." Dr. Sutcliffe and his team contacted patients throughout the UK who were in support groups for the disorders and obtained family histories and details of whether or not they had had ART, and if so, which kind. Out of 82 replies from families who had had a child with BWS, 10 had used ART in order to conceive (12%). Families with children with TND, AS, and PWS were also contacted and asked the same questions.

"We found that BWS was the only disorder where there was a significant risk for children conceived by ART", said Dr. Sutcliffe. "However, we found that all affected children apart from those with BWS had a mixture of genomic mutations, whereas those with BWS had a suggested mechanism maternal loss of methylation". Methylation is a mechanism used to inactivate parts of a chromosome to prevent problems.
'"/>

Contact: Mary Rice
mary@mrcommunication.org
European Society for Human Reproduction and Embryology
20-Jun-2005


Page: 1 2

Related biology news :

1. New strategy for treating allergic disorders
2. A new method of adult stem cell growth efficacious in treatment of disorders of the cornea
3. Double identities lie behind chromosome disorders
4. Study finds regions of DNA that appear linked to autistic spectrum disorders
5. Scientists find new agent to fight genetic disorders -- Zorro-Locked Nucleic Acid
6. Generalist genes linked to a variety of learning disorders
7. Eye movement tasks can be used to assess fetal alcohol spectrum disorders
8. Scientists uncover potential key to brain blood-flow disorders
9. Genetic mechanism helps explain chronic pain disorders
10. NIH launches Health Info Rx Program on newborn screening and related genetic disorders
11. Blame myelin for many neuropsychiatric disorders

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... The Department of Transport Management (DOTM) ... million US Dollar project, for the , Supply ... Enrolment, and IT Infrastructure , to ... implementation of Identity Management Solutions. Numerous renowned international vendors participated ... was selected for the most compliant and innovative ...
(Date:6/1/2016)... 1, 2016 Favorable Government Initiatives ... and Criminal Identification to Boost Global Biometrics System Market ... TechSci Research report, " Global Biometrics Market By ... and Opportunities, 2011 - 2021", the global biometrics market ... on account of growing security concerns across various end ...
(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... PHILADELPHIA , June 27, 2016  Liquid ... today announced the funding of a Sponsored Research ... study circulating tumor cells (CTCs) from cancer patients.  ... changes in CTC levels correlate with clinical outcomes ... therapies. These data will then be employed to ...
(Date:6/24/2016)... ... 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers use ... 6000i models are higher end machines that use the more unconventional z-dimension of 20mm. ... from the bottom of the cuvette holder. , FireflySci has developed several Agilent ...
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
(Date:6/23/2016)... ... 23, 2016 , ... Charm Sciences, Inc. is pleased to ... AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of the ... Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably ...
Breaking Biology Technology:
Cached News: