HOME >> BIOLOGY >> NEWS
Imprinting disorders and ART world's largest study results are reassuring

Further confirmation of a link between 'imprinting' disorders and assisted reproduction techniques (ART) was provided to the 21st annual conference of the European Society of Human Reproduction and Embryology today (Tuesday 21 June 2005). Dr. Alastair Sutcliffe, from the Department of Child Health, University College, London, UK, was reporting the results of the world's largest study into the relation between ART and four disorders known to be associated with aberrant genomic imprinting patterns.

Genetic imprinting is a mechanism in which gene expression depends upon parental origin. Mutations can alter normal imprinting, thus causing genetic abnormalities. Beckwith-Widermann syndrome (BWS) , Transient Neonatal Diabetes (TND), and Angelman syndrome (AS) and Prader-Willi syndrome (PWS) are all acquired because of either a maternal or paternal deletion on a chromosome or from inheritance of both chromosomes of a pair from one parent.

"It has been known for some time that BWS, for example, was associated with ART", said Dr. Sutcliffe, "and we set out to look at the association of all four disorders and assisted conception." Dr. Sutcliffe and his team contacted patients throughout the UK who were in support groups for the disorders and obtained family histories and details of whether or not they had had ART, and if so, which kind. Out of 82 replies from families who had had a child with BWS, 10 had used ART in order to conceive (12%). Families with children with TND, AS, and PWS were also contacted and asked the same questions.

"We found that BWS was the only disorder where there was a significant risk for children conceived by ART", said Dr. Sutcliffe. "However, we found that all affected children apart from those with BWS had a mixture of genomic mutations, whereas those with BWS had a suggested mechanism maternal loss of methylation". Methylation is a mechanism used to inactivate parts of a chromosome to prevent problems.
'"/>

Contact: Mary Rice
mary@mrcommunication.org
European Society for Human Reproduction and Embryology
20-Jun-2005


Page: 1 2

Related biology news :

1. New strategy for treating allergic disorders
2. A new method of adult stem cell growth efficacious in treatment of disorders of the cornea
3. Double identities lie behind chromosome disorders
4. Study finds regions of DNA that appear linked to autistic spectrum disorders
5. Scientists find new agent to fight genetic disorders -- Zorro-Locked Nucleic Acid
6. Generalist genes linked to a variety of learning disorders
7. Eye movement tasks can be used to assess fetal alcohol spectrum disorders
8. Scientists uncover potential key to brain blood-flow disorders
9. Genetic mechanism helps explain chronic pain disorders
10. NIH launches Health Info Rx Program on newborn screening and related genetic disorders
11. Blame myelin for many neuropsychiatric disorders

Post Your Comments:
(Date:7/31/2015)... The 10 th International Conference on Genomics (ICG-10, ... in Shenzhen , China ... anniversary this year. Since its inauguration in 2006, ICG ... in the ,omics, fields, and is one of the most ... focuses on recent breakthroughs and advances in ,omics, research that ...
(Date:7/23/2015)... BEDFORD, Mass., July 23, 2015 Aware, Inc. (NASDAQ: ... services, today reported financial results for its second quarter ended ... quarter of 2015 was $4.5 million, a decrease of 33% ...  Net income in the second quarter of 2015 was $0.3 ... million, or $0.04 per diluted share, in the same period ...
(Date:7/21/2015)... NEW YORK , July 21, 2015 /PRNewswire/ ... critical systems, as seen in the recent U.S. ... enterprises a solution to the infosec conundrum, but ... data is stored. To address this dilemma, Biometrics-as-a-Service ... of its Biometric Tokenization SDK for third party ...
Breaking Biology News(10 mins):The 10th International Conference on Genomics (ICG-10) to Open in October 2Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4
(Date:8/3/2015)... 3, 2015  MiMedx Group, Inc. (NASDAQ: MDXG ... tissue and patent-protected processes to develop and market advanced ... Spine, Sports Medicine, Ophthalmic and Dental sectors of healthcare, ... th Annual Canaccord|Genuity Growth Conference in ... and CEO, William C. Taylor , President and ...
(Date:8/3/2015)... DIEGO , Aug. 3, 2015  Aethlon Medical, Inc. ... biofiltration devices to treat life-threatening diseases, today announced that ... conference call and webcast on Thursday, August 13, 2015 ... and webcast will follow the release of fiscal 2016 ... will be available approximately two hours after the call ...
(Date:8/3/2015)... VANCOUVER, BC , Aug. 3, 2015 /PRNewswire/ - RepliCel ... regenerative medicine company focused on the development of autologous cell ... will be presenting at the InvestMNT conference held in ... at 8:15 AM local time. Hall,s presentation will highlight RepliCel,s ... for sale in Europe , clinical data ...
(Date:7/31/2015)... HONG KONG , July 31, 2015 ... "Company"), China,s leading provider of ... and stem cell storage services, today announced that the ... with the U.S. Securities and Exchange Commission. The filed ... year ended March 31, 2015. The Form 20-F can ...
Breaking Biology Technology:MiMedx To Present At 35th Annual Canaccord|Genuity Growth Conference 2Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2RepliCel Presenting at InvestMNT Investor Conference in Minneapolis 2China Cord Blood Corporation Files Its Annual Report on Form 20-F 2
Cached News: