HOME >> BIOLOGY >> NEWS
Improved statistical tools reveal many linked loci

An innovative new statistical method, described in the open-access journal PLoS Biology, streamlines the computation required to identify all the potential locations in the genome that influence a particular physical trait, or phenotype. Thanks to the new method developed by John Storey, Joshua M. Akey, and Leonid Kruglyak, researchers have a more efficient genome-mining technique to help them identify all the genomic elements that produce specific traits. In brewer's yeast alone, Storey and colleagues found that 37% of gene expression traits link to two loci, or positions in the genome.

"We were interested in being able to find combinations of genes that affect the phenotype," says Kruglyak. "It's generally thought that most traits of interest have a complex underlying genetic basis, but it's generally been pretty difficult to get at those." Typically, researchers might be able to find only one of the genetic factors, even though more than one genetic location contributes to the observed trait, such as blood pressure or cell growth.

The new statistical method bypasses the previously overwhelming computations needed to puzzle together the myriad elements that influence gene expression throughout an entire genome. And unlike earlier approaches to understanding how multiple loci interact, the new technique can distinguish between a group of genes with a linked subset and a group of genes with "joint linkage," where each gene site links to another.

"In some ways, it looks like you're complicating a problem because you're looking at thousands of genes instead of one trait," says Kruglyak. In reality, the method creates statistical conclusions that are more precise, he explains, because you're using so much data.

Storey et al. compared their method to another statistical method, called two-dimensional linkage analysis, which tests for linkage between all pa
'"/>

Contact: Paul Ocampo
press@plos.org
415-624-1224
Public Library of Science
25-Jul-2005


Page: 1 2

Related biology news :

1. Improved NIST SRM aids lead poisoning detection
2. Improved predictions of warming-induced extinctions sought
3. Improved imaging for identifying breast cancer in overweight women
4. Improved speech without vocal cords
5. Improved blood safety measures from Pall can increase platelet availability
6. Improved process of drying lumber may save millions
7. Improved cancer treatments aim of new biology research program
8. Improved recipe for magnetic brain stimulation
9. Improved molecular switch could serve as sensor, medical tool
10. Gene therapy study shows safety and statistically significant improvement in Parkinsons disease
11. In new statistical approach, data decide model

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Improved statistical tools reveal many linked loci

(Date:12/10/2014)... 9, 2014 CIE San Diego has launched ... the connective tissue that enhances care coordination among social ... share client-level information; earned a second $1 million grant ... serving seniors aging in community and; will be recognized ... 11 th 4-6p. CIE San Diego ...
(Date:12/5/2014)...  Tute Genomics, a leader in cloud-based solutions for ... funding led by UK-based Eurovestech. Peak Ventures and a ... round. "We are at a pivotal time ... and seeks new approaches for the diagnosis, treatment and ... MBA, and CEO of Tute Genomics. "One of the ...
(Date:11/21/2014)... According to a new market ... RFID, Access Control, Intrusion Detection, Parking Management, Under Vehicle ... Service Geography - Global Forecasts to 2020", published by ... be around $25 Billion in 2014 and is expected ... CAGR of 8.69%. Browse 116 market data ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
(Date:12/19/2014)... (PRWEB) December 18, 2014 ... nation’s leading specialty pharmacies, has an expanded team ... clinical pharmacy consultants for prescriber offices in their ... , “We have a variety of Regional ... example, those specializing in hepatitis C help prescribers ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 Reports from ... the United States suffer from one or more chronic ... or cancer. Medication can address some of these diseases, ... activities that many sufferers face. While implanted nerve stimulation ... stimulate the whole nerve, which can induce side effects. ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 With only ... time special on Sartorius Biohit products . The ... mLINE pipettes, Picus Electronic Pipette Trade-in Program, and free ... and Safety officers around the world. They are ideal ... Other features include:, ,     Full volume range ...
(Date:12/19/2014)... 2014 Relmada Therapeutics, Inc. (OTCQB: RLMD), a ... chronic pain, announced the results of its annual general ... a transformational year in Relmada,s history and it set ... said Sergio Traversa , chief executive officer of ... key financial, human resource and clinical development objectives that ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2
Cached News: