HOME >> BIOLOGY >> NEWS
Improved statistical tools reveal many linked loci

An innovative new statistical method, described in the open-access journal PLoS Biology, streamlines the computation required to identify all the potential locations in the genome that influence a particular physical trait, or phenotype. Thanks to the new method developed by John Storey, Joshua M. Akey, and Leonid Kruglyak, researchers have a more efficient genome-mining technique to help them identify all the genomic elements that produce specific traits. In brewer's yeast alone, Storey and colleagues found that 37% of gene expression traits link to two loci, or positions in the genome.

"We were interested in being able to find combinations of genes that affect the phenotype," says Kruglyak. "It's generally thought that most traits of interest have a complex underlying genetic basis, but it's generally been pretty difficult to get at those." Typically, researchers might be able to find only one of the genetic factors, even though more than one genetic location contributes to the observed trait, such as blood pressure or cell growth.

The new statistical method bypasses the previously overwhelming computations needed to puzzle together the myriad elements that influence gene expression throughout an entire genome. And unlike earlier approaches to understanding how multiple loci interact, the new technique can distinguish between a group of genes with a linked subset and a group of genes with "joint linkage," where each gene site links to another.

"In some ways, it looks like you're complicating a problem because you're looking at thousands of genes instead of one trait," says Kruglyak. In reality, the method creates statistical conclusions that are more precise, he explains, because you're using so much data.

Storey et al. compared their method to another statistical method, called two-dimensional linkage analysis, which tests for linkage between all pa
'"/>

Contact: Paul Ocampo
press@plos.org
415-624-1224
Public Library of Science
25-Jul-2005


Page: 1 2

Related biology news :

1. Improved NIST SRM aids lead poisoning detection
2. Improved predictions of warming-induced extinctions sought
3. Improved imaging for identifying breast cancer in overweight women
4. Improved speech without vocal cords
5. Improved blood safety measures from Pall can increase platelet availability
6. Improved process of drying lumber may save millions
7. Improved cancer treatments aim of new biology research program
8. Improved recipe for magnetic brain stimulation
9. Improved molecular switch could serve as sensor, medical tool
10. Gene therapy study shows safety and statistically significant improvement in Parkinsons disease
11. In new statistical approach, data decide model

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Improved statistical tools reveal many linked loci

(Date:7/24/2014)... different effects on different species of fish, according ... Bristol and Exeter which tested fish anti-predator behaviour. ... flying seagull predator model when exposed to additional ... minnows. , Lead author Dr Irene Voellmy ... levels in many aquatic environments have increased substantially ...
(Date:7/24/2014)... meaning the microbial populations found on surfaces in the ... final flavor according to research published ahead of print ... This is the first time investigators have taken a ... sake makers inoculate with both bacteria and yeast, says ... California, Davis, but he and his colleagues investigated a ...
(Date:7/24/2014)... NJIT this week for an all-day public forum on ... Agency (EPA) to dredge toxic sediment from an eight-mile ... has called the plan, which proposes removing 4.3 million ... the riverbed, one of the largest cleanups in the ... disposed off-site. , "We need to ensure the future ...
Breaking Biology News(10 mins):The microbes make the sake brewery 2Experts Weigh the Pros and Cons of a $1.7 Billion EPA Cleanup Plan for the Passaic River at an NJIT 2
(Date:7/24/2014)... forces worldwide rely on sophisticated equipment, trained personnel, ... public areas against terrorist attacks. A revolutionary new ... to make their job much easier. , The ... of Tel Aviv University ,s School of Chemistry ... by the Herzliya company Tracense, picks up the ...
(Date:7/24/2014)... natural and synthetic processes prefer to settle into ... energyit is within the realm of non-equilibrium conditions ... changes in energy and phases, such as temperature ... allow humans to regulate their body temperature, airplanes ... seismic activity. , But even though these ...
(Date:7/24/2014)... Calif. , July 24, 2014 SRI ... contract with the National Institute of Allergy and Infectious ... to conduct preclinical development of potential therapies for HIV ... drugs to treat HIV and AIDS and the complications ... as microbicides for preventing sexual transmission of HIV. ...
(Date:7/24/2014)... -- Neogen Corporation (Nasdaq: NEOG ) advised market ... from new rodenticide research are premature. In its regular ... 22, 2014, Neogen,s CEO commented about several new developments ... "It was my intent Tuesday at our conference call ... type of rodenticide, but certainly not to give any ...
Breaking Biology Technology:Nano-sized chip 'sniffs out' explosives far better than trained dogs 2New approach to form non-equilibrium structures 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3Neogen comments on SenesTech 2
Cached News: