HOME >> BIOLOGY >> NEWS
Improved statistical tools reveal many linked loci

An innovative new statistical method, described in the open-access journal PLoS Biology, streamlines the computation required to identify all the potential locations in the genome that influence a particular physical trait, or phenotype. Thanks to the new method developed by John Storey, Joshua M. Akey, and Leonid Kruglyak, researchers have a more efficient genome-mining technique to help them identify all the genomic elements that produce specific traits. In brewer's yeast alone, Storey and colleagues found that 37% of gene expression traits link to two loci, or positions in the genome.

"We were interested in being able to find combinations of genes that affect the phenotype," says Kruglyak. "It's generally thought that most traits of interest have a complex underlying genetic basis, but it's generally been pretty difficult to get at those." Typically, researchers might be able to find only one of the genetic factors, even though more than one genetic location contributes to the observed trait, such as blood pressure or cell growth.

The new statistical method bypasses the previously overwhelming computations needed to puzzle together the myriad elements that influence gene expression throughout an entire genome. And unlike earlier approaches to understanding how multiple loci interact, the new technique can distinguish between a group of genes with a linked subset and a group of genes with "joint linkage," where each gene site links to another.

"In some ways, it looks like you're complicating a problem because you're looking at thousands of genes instead of one trait," says Kruglyak. In reality, the method creates statistical conclusions that are more precise, he explains, because you're using so much data.

Storey et al. compared their method to another statistical method, called two-dimensional linkage analysis, which tests for linkage between all pa
'"/>

Contact: Paul Ocampo
press@plos.org
415-624-1224
Public Library of Science
25-Jul-2005


Page: 1 2

Related biology news :

1. Improved NIST SRM aids lead poisoning detection
2. Improved predictions of warming-induced extinctions sought
3. Improved imaging for identifying breast cancer in overweight women
4. Improved speech without vocal cords
5. Improved blood safety measures from Pall can increase platelet availability
6. Improved process of drying lumber may save millions
7. Improved cancer treatments aim of new biology research program
8. Improved recipe for magnetic brain stimulation
9. Improved molecular switch could serve as sensor, medical tool
10. Gene therapy study shows safety and statistically significant improvement in Parkinsons disease
11. In new statistical approach, data decide model

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Improved statistical tools reveal many linked loci

(Date:10/14/2014)... the house fly genome for the first time, revealing ... insect that thrives in pathogen-rich dung piles and garbage ... journal Genome Biology , will increase understanding of ... quickly adapt to resist insecticides, which could lead to ... carry and transmit more than 100 human and animal ...
(Date:10/14/2014)... research team has discovered a new kind of stem cell ... that lines liver blood vessels, according to a study published ... existence of such a cell type contradicts current theory on ... may hold clues to origins of, and future treatment for, ... single cell into a complex being made up of more ...
(Date:10/14/2014)... 14, 2014 – Scientists from The Scripps Research Institute ... Institutes of Health (NIH) to lead an investigation of ... disease in Africa. The study aims to understand how ... die, while others survive the inflection. , "The ... mechanism of how Lassa fever virus causes disease and ...
Breaking Biology News(10 mins):House fly genome reveals expanded immune system 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 3Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
(Date:10/20/2014)... BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced four ... million and provides a good start to Q4.  The orders are ... and one in the Middle East . ... said Peter Bruijns , President & CEO. "Total bidding activity ... they have been for any complete year since the company has ...
(Date:10/20/2014)... N.J. (PRWEB) October 20, 2014 ... the Sidney Kimmel Cancer Center at Thomas Jefferson ... , Through the Strategic Alliance Partnership program, ... OncLive will collaborate to raise awareness of the ... treatment, and other projects. Clinicians and other health ...
(Date:10/19/2014)... October 20, 2014 OCTOBER ... Meeting (ABIM). ABIM will take place ... information about ABIM 2014 is now available ... Delegates representing companies and organizations from all ... obtain information on the latest products and ...
(Date:10/19/2014)... The Asia-Pacific Speech Analytics market report ... with analysis and forecast of revenue. This market is ... $208 million by 2019, at a Compound Annual Growth ... Browse through the TOC of the Asia-Pacific Speech Analytics ... analysis provided. It also provides a glimpse of the ...
Breaking Biology Technology:Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4
Cached News: