HOME >> BIOLOGY >> NEWS
Improving the potential of cancer vaccines

HOUSTON -- (Aug. 26, 2005) -- A special stretch of genetic material may turn off the immune suppression that stymies attempts to fight cancer with a vaccine, said researchers at Baylor College of Medicine (BCM) at Houston.

In a report in today's issue of the journal Science, Dr. Rong-Fu Wang, a professor in the BCM Center for Cell and Gene Therapy and Department of Immunology, and his colleagues describe a new strategy to turn off the function of a special group of T cells to suppress immune response to tumors and even infectious diseases.

"Since 1995, many groups have tried to develop a vaccine for the treatment of cancer," said Wang, also a member of the faculty of the BCM Graduate School of Biomedical Sciences. "The only problem is that after 10 years of clinical trials, the data suggest that you can induce (cancer) antigen-specific immune responses, but such responses are too weak and transient to eradicate tumor cells."

The answer lies in a group of cells called CD4+ regulatory T cells (Treg for short). These cells have the ability to suppress the body's natural immune response. If they are depleted, autoimmune diseases will result because the immune system is unchecked and goes on to attack the body's own tissues.

His group previously reported the existence of tumor-specific Treg cells at tumor sites. "Thus, the tumor cells use these Treg cells to protect themselves," said Wang. "In fact, tumor cells can actively recruit and activate them to turn on their immune suppressive function."

One way to stop this action is to simply wipe out the cells with chemoagents or a specific antibody.

"But you may also deplete the good cells needed for fighting cancer," said Wang.

He and his group identified particular ligands (a special stretch of guanosine-containing DNA material) that can bind specifically to a particular receptor called human Toll-like receptor 8 and then turn off the suppressive function of Treg cells
'"/>

Contact: Ross Tomlin
htomlin@bcm.edu
713-798-4712
Baylor College of Medicine
26-Aug-2005


Page: 1 2

Related biology news :

1. Improving plants abilities to cope with saline conditions
2. Spotlight on liver disease: Improving todays treatments
3. Health care reimagined: Improving patient care through early health
4. Improving outcomes in premature births
5. Improving livestock health, trade and human livelihoods in Africa
6. Improving urban environments: why childrens voices should be heard
7. Improving police cars, recovering lost manuscripts: UH research day delivers
8. Improving artificial heart top goal of award-winning research at UH
9. UCF research links proteins, stem cells and potential Alzheimers treatment
10. Picky eating potentially perilous for bats
11. Scientists take next step in understanding potential target for ovarian cancer treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... England (PRWEB) , ... June 23, 2020 , ... ... Africa supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and manufacturer of ... project to support testing operations in the fight against the COVID-19 pandemic in ...
(Date:6/23/2020)... , ... June 23, 2020 , ... ... is pleased to announce the next event in a series of TOPIQ webinars, ... The TOPIQ series of webinars was developed in response to social distancing measures ...
(Date:6/19/2020)... ... June 16, 2020 , ... The director of stem cell biotechnology company ... stem cell medicine and pharmaceutical industries have easier access to stem cell counting, they ... 5 of this year, Independence Day weekend in the U.S., Asymmetrex is offering free ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 12, 2020 , ... Inc. magazine today revealed that ... FDA compliance consulting has been named on its annual Inc. 5000 list, the ... unique look at the most successful companies within the American economy’s most dynamic ...
(Date:8/3/2020)... ... August 03, 2020 , ... ... Jim Corrigan, President and CEO has been named one of the 100 most ... industry sectors, PharmaVoice 100 honorees are selected based on how they have inspired ...
(Date:7/31/2020)... ... ... R3 Stem Cell International is now offering patients the opportunity to receive ... patients may choose which extremities they would like treated. , Several studies have shown ... At R3 International, umbilical cord tissue is obtained from a lab with a long ...
(Date:7/31/2020)... ... 2020 , ... Diversified Technologies, Inc. has introduced a full ... drive Klystrons, TWTs, IOTs, and magnetrons. , DTI Radar Transmitter Systems ... push-pull configuration; yielding fast fall time for a capacitive load. These all solid-state ...
Breaking Biology Technology:
Cached News: