HOME >> BIOLOGY >> NEWS
In 3D, early fat development first requires 'remodeling'

In the May 5, 2006 Cell, researchers report the serendipitous discovery that the initial development of fat requires a "remodeling" protein that must first make way for the lipid-laden tissue's growth. An enzyme that "chews" through collagen fibers sculpts the matrix surrounding fat cells, allowing them to expand and mature, the team reports.

In the absence of the collagen-busting "membrane-anchored metalloproteinase" (MT1-MMP), would-be fat cells, or preadipocytes, fail to break through the fibrous extracellular matrix, they found. Moreover, the cells entrapment within a dense collagen meshwork disrupts their structure. That structural change, in turn, stalls the genetic programs critical for full-blown fat development, leading to sweeping changes in gene activity.

In contrast, they report, fat cells deficient for MT1-MMP develop apparently normally when placed on the flat surface of a laboratory dish.

"When small fat cells embedded in what is essentially a 3D molecular cage receive the appropriate external signals during development, it appears that they change their geometry--remodeling the surrounding matrix using an enzyme to chew the fibers," said the study's senior author Stephen Weiss of the University of Michigan, Ann Arbor.

For reasons that are not entirely clear, that shape change leads to a dramatic shift in gene expression and cell behavior, he added. In the absence of the collagen-rich 3-dimensional matrix, the MT1-MMP enzyme apparently becomes irrelevant.

The study identifies MT1-MMP as a "heretofore unsuspected 3-dimensional matrix specific regulator of white adipose tissue development and function," the researchers said. White adipose tissue is a type of fat that serves as a primary depot for energy stores.

Moreover, the findings in developing mice raise the possibility that the enzyme might also play an important role in the remodeling of extracellular barriers in adult animals as they gain or burn f
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
4-May-2006


Page: 1 2 3 4

Related biology news :

1. An early ape shows its hand
2. Purdue-IU researchers explore new method for early disease diagnosis
3. Nearly 90 percent of babies receive recommended newborn screening tests
4. A first-principles model of early evolution
5. New blood test might offer early warning of deep belly fat
6. Marine worm opens new window on early cell development
7. Modular leukemia drug shows promise in early testing
8. Noninvasive screening in early pregnancy reduces Downs births by 50 percent
9. 454 sequencing identifies HIV drug resistance at early stage
10. Ultra deep sequencing identifies HIV drug resistance at early stage
11. Bacteria ferry nanoparticles into cells for early diagnosis, treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017  IBM ... in dairy research, today announced a new collaboration using ... the chances that the global milk supply is impacted ... project, Cornell University has become the newest academic institution ... Chain, a food safety initiative that includes IBM Research, ...
(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
(Date:4/18/2017)... SUNNYVALE, Calif. , April 18, 2017  Socionext Inc., a ... prototype of a media edge server, the M820, which features the ... face recognition software provided by Tera Probe, Inc., will be showcased ... and at the NAB show at the Las Vegas ... ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... September 19, 2017 , ... Participants ... and a high-performance fume hood. Along with the advantages and disadvantages of ductless, ... vs. ducted hoods in the laboratory. , Attendees will learn from an industry ...
(Date:9/19/2017)... ... September 19, 2017 , ... The new and improved ... The pocket testers even stand upright with a new cap design that is versatile, ... in the field who need to test water quality. , The Oakton pocket testers ...
(Date:9/19/2017)... MI (PRWEB) , ... September 19, 2017 , ... ... laboratory, is pleased to announce the recipients of its 2017 Science Student Award. ... exceptional leadership qualities, and involvement with community service defray the costs of obtaining ...
(Date:9/19/2017)... ... September 19, 2017 , ... Band-LOK, LLC, an ... today that two new patents have been allowed by the USPTO on the ... said, “We continue to explore additional clinically-relevant designs for both the implants and ...
Breaking Biology Technology:
Cached News: