HOME >> BIOLOGY >> NEWS
In 3D, early fat development first requires 'remodeling'

In the May 5, 2006 Cell, researchers report the serendipitous discovery that the initial development of fat requires a "remodeling" protein that must first make way for the lipid-laden tissue's growth. An enzyme that "chews" through collagen fibers sculpts the matrix surrounding fat cells, allowing them to expand and mature, the team reports.

In the absence of the collagen-busting "membrane-anchored metalloproteinase" (MT1-MMP), would-be fat cells, or preadipocytes, fail to break through the fibrous extracellular matrix, they found. Moreover, the cells entrapment within a dense collagen meshwork disrupts their structure. That structural change, in turn, stalls the genetic programs critical for full-blown fat development, leading to sweeping changes in gene activity.

In contrast, they report, fat cells deficient for MT1-MMP develop apparently normally when placed on the flat surface of a laboratory dish.

"When small fat cells embedded in what is essentially a 3D molecular cage receive the appropriate external signals during development, it appears that they change their geometry--remodeling the surrounding matrix using an enzyme to chew the fibers," said the study's senior author Stephen Weiss of the University of Michigan, Ann Arbor.

For reasons that are not entirely clear, that shape change leads to a dramatic shift in gene expression and cell behavior, he added. In the absence of the collagen-rich 3-dimensional matrix, the MT1-MMP enzyme apparently becomes irrelevant.

The study identifies MT1-MMP as a "heretofore unsuspected 3-dimensional matrix specific regulator of white adipose tissue development and function," the researchers said. White adipose tissue is a type of fat that serves as a primary depot for energy stores.

Moreover, the findings in developing mice raise the possibility that the enzyme might also play an important role in the remodeling of extracellular barriers in adult animals as they gain or burn f
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
4-May-2006


Page: 1 2 3 4

Related biology news :

1. An early ape shows its hand
2. Purdue-IU researchers explore new method for early disease diagnosis
3. Nearly 90 percent of babies receive recommended newborn screening tests
4. A first-principles model of early evolution
5. New blood test might offer early warning of deep belly fat
6. Marine worm opens new window on early cell development
7. Modular leukemia drug shows promise in early testing
8. Noninvasive screening in early pregnancy reduces Downs births by 50 percent
9. 454 sequencing identifies HIV drug resistance at early stage
10. Ultra deep sequencing identifies HIV drug resistance at early stage
11. Bacteria ferry nanoparticles into cells for early diagnosis, treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... MELBOURNE, Florida , April 11, 2017 ... "Company"), a security technology company, announces the appointment of independent ... John Bendheim to its Board of Directors, furthering the ... ... behalf of NXT-ID, we look forward to their guidance and ...
(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
(Date:3/30/2017)... HONG KONG , March 30, 2017 ... developed a system for three-dimensional (3D) fingerprint identification by adopting ground ... technology into a new realm of speed and accuracy for use ... applications at an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:7/26/2017)... ... July 26, 2017 , ... ... complex problems we face every day. This unique capability combines high resolution ... chemists, and manufacturers to deliver unprecedented datasets for chemical analysis, quality control, and ...
(Date:7/26/2017)...  Nurse practitioners play a crucial role in helping patients ... Merck Manuals survey released today. The survey of 210 ... (88 percent) believe they spend at least half of appointment ... ... Manuals survey of 210 nurse practitioners finds that 78% of ...
(Date:7/24/2017)... , ... July 24, 2017 , ... Charm Sciences, Inc. ... accepted by the National Conference on Interstate Milk Shipments (NCIMS) Laboratory Committee and Appendix ... set to launch July 1, 2017. , The NCIMS voted at its annual meeting ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... ., the Elihu Thomson Professor of Electrical Engineering and Computer Science at the ... winner. Presented annually, the award recognizes an individual who has made and is ...
Breaking Biology Technology:
Cached News: