In anoxia, why can't humans be more like western painted turtles?

San Diego (April 3, 2005) For a human, mere minutes without oxygen (called anoxia) resulting from cardiac arrest, cerebral stroke or being trapped under water can lead to profound tissue damage and even death. However a Western painted turtle can survive anoxia for months without apparent tissue damage. Why, and how?

"Key to surviving anoxia is the shutting off of energy-utilizing cellular activities, such as the synthesis of proteins and perhaps most importantly reducing the activity of energy intensive ion pumps," according to Leslie T. Buck, a physiologist at University of Toronto's Zoology Department. Whereas turtles and many other animals have shutoff mechanisms, humans and many mammals don't.

"However, basic biochemical pathways are common to almost all species, certainly among reptiles (turtles), fish, birds and mammals," Buck said, adding: "Therefore, the basic signals and pathways that permit anoxia-tolerance in the turtle must also be present in mammals."

In studying the natural mechanisms of anoxia tolerance, Buck's lab focused on a particular ion channel, the N-methyl-D-aspartate (NMDA) receptor. This receptor/channel is strongly associated with anoxic damage in the mammalian brain by permitting a very large flow of calcium ions into the cell during anoxia. Unlike anoxia-sensitive mammals, this doesn't occur in the western painted turtle's brain.

*Paper presentation: "NMDA receptor regulation by mitochondrial KATP channels and adenosine receptors in cortical neurons of the anoxia-tolerant western painted turtle," 12:30 p.m.-3 p.m. Sunday April 3, Physiology 381.3/board #A558. On view 7:30 a.m. - 4 p.m. Others in the research team are Damian Shin and Matthew Pamenter.

Featured topic: Buck is also participating in "Mechanisms of metabolic depression: comparative aspects," Sunday April 3, room 30 B/C beginning at 10:30 a.m. His presentation is scheduled for noon.

Buck is presenting the research at the 3


Page: 1 2

Related biology news :

1. Chronically sleep deprived? You cant make up for lost sleep
2. Why some aphids cant stand the heat
3. Museum-fueled global study shows you cant judge biodiversity by its bird
4. You cant scare people into getting fit or going green
5. When nerve cells cant make contact
6. Empty nesters cant let go
7. You cant rely on firearms forensics
8. The reason why antiviral therapy cant annihilate HIV infection, and what to do about it
9. Plankton can run, but cant hide from basking sharks
10. Scientists find viruses cant stick to sea bugs in the dark
11. You cant buy conservation, suggests survey of Africas rain forest parks

Post Your Comments:

(Date:10/29/2015)... 2015 Daon, a global leader in mobile ... a new version of its IdentityX Platform , ... America have already installed IdentityX v4.0 and ... FIDO UAF certified server component as an ... FIDO features. These customers include some of the largest ...
(Date:10/27/2015)... 2015 In the present market scenario, security ... various industry verticals such as banking, healthcare, defense, electronic ... demand for secure & simplified access control and growing ... hacking of bank accounts, misuse of users, , and ... PC,s, laptops, and smartphones are expected to provide potential ...
(Date:10/26/2015)... 2015  Delta ID Inc., a company focused on ... PC devices, announced its ActiveIRIS® technology powers the iris ... launched by NTT DOCOMO, INC in Japan ... smartphone to include iris recognition technology, after a very ... in May 2015, world,s first smartphone to have this ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... N.C. , Nov. 24, 2015  Clintrax Global, Inc., a ... North Carolina , today announced that the company has set ... represented a 391% quarter on quarter growth posted for Q3 of ... and Mexico , with the establishment ... in December 2015. --> United Kingdom ...
(Date:11/24/2015)... ... November 24, 2015 , ... This fall, global software solutions leader ... five states to develop and pitch their BIG ideas to improve health and wellness ... competing for votes to win the title of SAP's Teen Innovator, an all-expenses paid ...
(Date:11/24/2015)... , November 24, 2015 SHPG ) ... participate in the Piper Jaffray 27 th Annual Healthcare Conference ... December 1, 2015, at 8:30 a.m. EST (1:30 p.m. GMT). ... Chief Financial Officer, will participate in the Piper Jaffray 27 th ... , NY on Tuesday, December 1, 2015, at 8:30 a.m. EST ...
(Date:11/24/2015)... , Nov. 24, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) today ... December 29, 2015 at 11:00 a.m. Israel time, ... Tower, 98 Yigal Allon Street, 36 th Floor, Tel ... Eric Paneth and Izhak Tamir to the Board ... Skaliter as external directors; , approval of an amendment to certain ...
Breaking Biology Technology:
Cached News: