HOME >> BIOLOGY >> NEWS
In anoxia, why can't humans be more like western painted turtles?

San Diego (April 3, 2005) For a human, mere minutes without oxygen (called anoxia) resulting from cardiac arrest, cerebral stroke or being trapped under water can lead to profound tissue damage and even death. However a Western painted turtle can survive anoxia for months without apparent tissue damage. Why, and how?

"Key to surviving anoxia is the shutting off of energy-utilizing cellular activities, such as the synthesis of proteins and perhaps most importantly reducing the activity of energy intensive ion pumps," according to Leslie T. Buck, a physiologist at University of Toronto's Zoology Department. Whereas turtles and many other animals have shutoff mechanisms, humans and many mammals don't.

"However, basic biochemical pathways are common to almost all species, certainly among reptiles (turtles), fish, birds and mammals," Buck said, adding: "Therefore, the basic signals and pathways that permit anoxia-tolerance in the turtle must also be present in mammals."

In studying the natural mechanisms of anoxia tolerance, Buck's lab focused on a particular ion channel, the N-methyl-D-aspartate (NMDA) receptor. This receptor/channel is strongly associated with anoxic damage in the mammalian brain by permitting a very large flow of calcium ions into the cell during anoxia. Unlike anoxia-sensitive mammals, this doesn't occur in the western painted turtle's brain.

*Paper presentation: "NMDA receptor regulation by mitochondrial KATP channels and adenosine receptors in cortical neurons of the anoxia-tolerant western painted turtle," 12:30 p.m.-3 p.m. Sunday April 3, Physiology 381.3/board #A558. On view 7:30 a.m. - 4 p.m. Others in the research team are Damian Shin and Matthew Pamenter.

Featured topic: Buck is also participating in "Mechanisms of metabolic depression: comparative aspects," Sunday April 3, room 30 B/C beginning at 10:30 a.m. His presentation is scheduled for noon.

Buck is presenting the research at the 3
'"/>


3-Apr-2005


Page: 1 2

Related biology news :

1. Chronically sleep deprived? You cant make up for lost sleep
2. Why some aphids cant stand the heat
3. Museum-fueled global study shows you cant judge biodiversity by its bird
4. You cant scare people into getting fit or going green
5. When nerve cells cant make contact
6. Empty nesters cant let go
7. You cant rely on firearms forensics
8. The reason why antiviral therapy cant annihilate HIV infection, and what to do about it
9. Plankton can run, but cant hide from basking sharks
10. Scientists find viruses cant stick to sea bugs in the dark
11. You cant buy conservation, suggests survey of Africas rain forest parks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2016)... UAE, April 20, 2016 The ... as a compact web-based "all-in-one" system solution for all ... fingerprint reader or the door interface with integration authorization ... access control systems. The minimal dimensions of the access ... into the building installations offer considerable freedom of design ...
(Date:4/14/2016)... April 14, 2016 BioCatch ... Detection, today announced the appointment of Eyal Goldwerger ... role. Goldwerger,s leadership appointment comes at a ... of the deployment of its platform at several of ... technology, which discerns unique cognitive and physiological factors, is ...
(Date:3/31/2016)... R.I. , March 31, 2016  Genomics firm ... of founding CEO, Barrett Bready , M.D., who ... members of the original technical leadership team, including Chief ... President of Product Development, Steve Nurnberg and Vice President ... returned to the company. Dr. Bready served ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... -- Global demand for enzymes is forecast to grow ... billion.  This market includes enzymes used in industrial ... animal feed, and other markets) and specialty applications ... beverages will remain the largest market for enzymes, ... containing enzymes in developing regions.  These and other ...
(Date:6/27/2016)... 2016  Sequenom, Inc. (NASDAQ: SQNM ), ... through the development of innovative products and services, announced ... United States denied its petition to review ... Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are not ... the Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories ...
(Date:6/27/2016)... CA (PRWEB) , ... June 27, 2016 , ... ... for clinical trials, announced today the Clinical Reach Virtual Patient Encounter CONSULT ... care circle with the physician and clinical trial team. , Using the CONSULT module, ...
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf ... join the faculty of the University of North Carolina Kenan-Flagler Business School ... and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international efforts, ...
Breaking Biology Technology:
Cached News: