HOME >> BIOLOGY >> NEWS
In anoxia, why can't humans be more like western painted turtles?

San Diego (April 3, 2005) For a human, mere minutes without oxygen (called anoxia) resulting from cardiac arrest, cerebral stroke or being trapped under water can lead to profound tissue damage and even death. However a Western painted turtle can survive anoxia for months without apparent tissue damage. Why, and how?

"Key to surviving anoxia is the shutting off of energy-utilizing cellular activities, such as the synthesis of proteins and perhaps most importantly reducing the activity of energy intensive ion pumps," according to Leslie T. Buck, a physiologist at University of Toronto's Zoology Department. Whereas turtles and many other animals have shutoff mechanisms, humans and many mammals don't.

"However, basic biochemical pathways are common to almost all species, certainly among reptiles (turtles), fish, birds and mammals," Buck said, adding: "Therefore, the basic signals and pathways that permit anoxia-tolerance in the turtle must also be present in mammals."

In studying the natural mechanisms of anoxia tolerance, Buck's lab focused on a particular ion channel, the N-methyl-D-aspartate (NMDA) receptor. This receptor/channel is strongly associated with anoxic damage in the mammalian brain by permitting a very large flow of calcium ions into the cell during anoxia. Unlike anoxia-sensitive mammals, this doesn't occur in the western painted turtle's brain.

*Paper presentation: "NMDA receptor regulation by mitochondrial KATP channels and adenosine receptors in cortical neurons of the anoxia-tolerant western painted turtle," 12:30 p.m.-3 p.m. Sunday April 3, Physiology 381.3/board #A558. On view 7:30 a.m. - 4 p.m. Others in the research team are Damian Shin and Matthew Pamenter.

Featured topic: Buck is also participating in "Mechanisms of metabolic depression: comparative aspects," Sunday April 3, room 30 B/C beginning at 10:30 a.m. His presentation is scheduled for noon.

Buck is presenting the research at the 3
'"/>


3-Apr-2005


Page: 1 2

Related biology news :

1. Chronically sleep deprived? You cant make up for lost sleep
2. Why some aphids cant stand the heat
3. Museum-fueled global study shows you cant judge biodiversity by its bird
4. You cant scare people into getting fit or going green
5. When nerve cells cant make contact
6. Empty nesters cant let go
7. You cant rely on firearms forensics
8. The reason why antiviral therapy cant annihilate HIV infection, and what to do about it
9. Plankton can run, but cant hide from basking sharks
10. Scientists find viruses cant stick to sea bugs in the dark
11. You cant buy conservation, suggests survey of Africas rain forest parks

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: anoxia why can humans more like western painted turtles

(Date:11/5/2014)... career to understanding the Earth,s climate and communicating ... deputy director and regional climatologist for the Western ... Redmond has more than three decades of experience ... data to the general public. , At its ... December 15-19, 2014 the American Geophysical Union (AGU) ...
(Date:11/4/2014)... 2014 – University of Utah engineers developed the first ... fuel produce electricity without needing to ignite the fuel. ... portable electronics, off-grid power and sensors. , A study ... American Chemical Society journal ACS Catalysis . , ... reaction between a fuel and an oxygen-rich source such ...
(Date:11/4/2014)... University School of Medicine announced today that it ... funded by the Bill & Melinda Gates Foundation. ... Gynecology and Reproductive Sciences; and Vice Chair of ... of Medicine will pursue an innovative global health ... to Assess Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) ...
Breaking Biology News(10 mins):Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2Jet-fueled electricity at room temperature 2Temple University School of Medicine receives Grand Challenges Explorations grant 2
(Date:11/22/2014)... During his lifetime Richard L. Sharp was ... himself with great people and take risks to achieve ... marveled at his extraordinarily courageous attitude when taking on ... even with his death impending—that’s how he continued looking ... ultimately take his life. , Carrying on Sharp’s relentless ...
(Date:11/22/2014)... (PRWEB) November 21, 2014 RURO, ... solutions provider, has released Limfinity® version 5.1.4. , ... projects of Limfinity® than ever in RURO’s 8 ... and minority framework enhancement. Limfinity® version 5.1.4 is ... above and beyond bug fixes! , Limfinity® 5.1.4 ...
(Date:11/22/2014)... 22, 2014 Respiratory therapy students ... proper management of life-like respiratory ailments using the ... . Grand Rapids-based, Michigan Instruments Inc. developers of ... of the respiratory simulation units to the pro-gram, ... Valley and Muskegon Community College are collaborating to ...
(Date:11/21/2014)... Quebec , November 21, 2014 ... como responsable comercial   Mariano Rodríguez es ...   KLOX está en marcha para comenzar ... de cura de heridas de reciente aprobación en Europa   ... "la compañía") se complace al anunciar los siguientes nombramientos: ...
Breaking Biology Technology:Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 3RURO Announces Limfinity® version 5.1.4 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5
Cached News: