HOME >> BIOLOGY >> NEWS
In anoxia, why can't humans be more like western painted turtles?

5th Congress of the International Union of Physiological Sciences in San Diego, March 31 - April 5, 2005.

New potassium channel blockage short-circuits turtle's shutoff mechanism

A known protective factor is adenosine, a compound that accumulates in both mammalian and reptile (turtle) brains in response to low oxygen levels. It reduces the inflow of calcium through NMDA receptors during anoxia and is associated with brain protection. "However, our work suggests that adenosine isn't the only protective factor. Even with the adenosine pathways inhibited, calcium influx in anoxic turtle brain still decreases," Buck noted.

Mathew Pamenter, a graduate student in the lab, had the idea to investigate a relatively newly discovered potassium channel (mitochondrial KATP channel) as a possible regulator of NMDA receptor activity during anoxia. "When this new channel was inhibited, the protective decrease in calcium influx previously observed in anoxic turtle brain didn't occur," Buck said. "This result indicates that this channel plays a key role in the natural anoxia-tolerance of the turtle and opens a new research direction in this area."

Next steps. Buck said one avenue of investigation is to see whether the potassium channels may be part of an oxygen sensing mechanism, which some believe. "Our ultimate goal is to determine the natural cellular pathways responsible for oxygen sensing and the shutting off of energy consuming processes in the turtle," Buck said. "Then I want to apply this knowledge to human clinical situations, such as improving outcomes of cerebral stroke and cardiac infarct, and the development of better anesthetics."


'"/>


3-Apr-2005


Page: 1 2

Related biology news :

1. Chronically sleep deprived? You cant make up for lost sleep
2. Why some aphids cant stand the heat
3. Museum-fueled global study shows you cant judge biodiversity by its bird
4. You cant scare people into getting fit or going green
5. When nerve cells cant make contact
6. Empty nesters cant let go
7. You cant rely on firearms forensics
8. The reason why antiviral therapy cant annihilate HIV infection, and what to do about it
9. Plankton can run, but cant hide from basking sharks
10. Scientists find viruses cant stick to sea bugs in the dark
11. You cant buy conservation, suggests survey of Africas rain forest parks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: