HOME >> BIOLOGY >> NEWS
Inactive form of scatter factor protein found to suppress tumor growth and spread

Scatter factor (SF) is a growth factor that controls the proliferation and survival of many tissues by promoting invasive growth in both normal and disease-related biological processes. Produced in a precursor form, pro-SF must be cleaved in order to activate its receptor, Met tyrosine kinase. In the November 15 issue of the Journal of Clinical Investigation, Paolo Michieli and colleagues developed an uncleavable form of pro-SF and used it in a gene therapy approach in mice to inhibit invasive tumor growth. Administration of the uncleavable pro-SF at the site of the tumor prevented the development of new blood vessels to the tumor, tumor growth, and tumor spread to other tissues, without affecting any normal physiological functions. The study demonstrates that the cleavage of pro-SF is an important step in the progression of tumor development and also suggests that drugs that inhibit this cleavage may lead to successful anti-cancer therapies.


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Nov-2004


Page: 1

Related biology news :

1. Whats the backscatter of your beer?
2. Diffraction and scattering -- the solution to whats in solution
3. Light scattering method reveals details under skin
4. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
5. OHSU turns mouse into factory for human liver cells
6. Genetic factors strongly shape how peers are chosen
7. Injection drug use the most important risk factor for HIV and HCV infections among Quebec prisoners
8. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
9. New model for autism suggests women carry the disorder and explains age as a risk factor
10. Obesity found to be a risk factor for multiple myeloma
11. Journal of Alzheimers Disease achieves significant impact factor

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/24/2020)... ... January 24, 2020 , ... The Rockies Venture ... resources to support early-stage bioscience companies in the state. , “Colorado ... find the funding they need to innovate and grow. This program will ...
(Date:1/23/2020)... ... , ... GIOSTAR/HEAMGEN has developed and secured patented ... red blood cells are made utilizing a bioreactor that permits the production of ... the need for a human blood donor. GIOSTAR/HEAMGEN mature red blood ...
(Date:1/22/2020)... ... ... Biotechnologies announces the new line of high purity powder chemicals filled into multiuse or ... and accurately weighed to 0.001 of a gram. The new line of powder chemicals includes:, ... Carbohydrates , Phosphates , Chelators , Chaotropic ...
Breaking Biology News(10 mins):
(Date:2/21/2020)... ... February 20, 2020 , ... The dietary supplement ... consumers that what’s listed on an ingredient panel is actually in their product. ... solution with the adoption of CertainT, which is designed to protect the intellectual ...
(Date:2/19/2020)... ... February 18, 2020 , ... Intech , the ... a new and unified global brand identity, as it celebrates its 20th anniversary. ... as well as an enthusiasm for designing and manufacturing state-of-the-art medical devices, Intech ...
(Date:2/11/2020)... ... February 11, 2020 , ... Synagro ... North America, today announced that the City of Fort Worth has partnered with ... needs. Commencing in April of 2020, Synagro will assume operation of the city’s ...
(Date:2/3/2020)... ... February 03, 2020 , ... Ovation Travel Group ... Technology Industry Travel and Biotech/Healthcare Industry Travel Indexes. , All of the Indexes ... statistics:, Average airfare price paid Domestically, Internationally and ...
Breaking Biology Technology:
Cached News: