HOME >> BIOLOGY >> NEWS
Increased sensitivity to nerve signals keeps diabetes at bay

Nerve signals relayed directly to the pancreas after eating a meal play a critical role in normal blood sugar control, according to a report in the June 7, 2006, Cell Metabolism. Therefore, drugs that increase the sensitivity to such signals might offer a new approach to diabetes treatment, the researchers said.

Mice in which the pancreas cells that produce insulin, or beta cells, lack so-called M3 muscarinic acetylcholine receptors develop some symptoms of diabetes, including impaired glucose tolerance and reduced insulin release, the authors report. M3 receptors are normally on the receiving end of messages relayed by involuntary nerves that indicate the presence of food.

In contrast, mice genetically altered to harbor an excess number of beta cell M3 receptors show the opposite: a profound increase in glucose tolerance and insulin release, the researchers found. Moreover, such animals become resistant to developing symptoms of diabetes or prediabetes when fed a high-fat diet.

The findings suggest that drugs that boost the activity of the M3 receptors on pancreatic beta cells might have therapeutic potential, said Jurgen Wess of the National Institute of Diabetes and Digestive and Kidney Diseases.

"There may be ways to specifically drive up the number of M3 receptors expressed in pancreatic beta cells," Wess said. "It might also be possible to enhance M3 receptor signaling in beta cells by targeting proteins that modulate M3 receptor function in a specific fashion."

Receptors of the same type are also found in other parts of the body, he explained. Therefore, drugs that directly stimulate M3 receptors in general would likely come with problematic side effects--for example, causing smooth muscles to contract.

One of three branches of the involuntary nervous system, the parasympathetic, or "rest and digest" system fulfills many roles--slowing the heart rate, dilating blood vessels, and stimulating digestive secretions.
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
6-Jun-2006


Page: 1 2

Related biology news :

1. Increased risk of hantavirus forecast for US southwest
2. Increased environmental carbon levels the good news!
3. Increased competition for pollen may lead to plant extinctions
4. Increased sexual competition among flowering plants in biodiversity hotspots may lead to extinctions
5. Increased dampness causes vegetation change
6. Increased risk of osteoporosis associated with gene that one in five people have
7. Drought sensitivity shapes species distribution patterns in tropical forests
8. J&JPRD discovery may lead to new treatments for chronic sensitivity, pain caused by cold
9. Breast cancer milieu -- Progression, tamoxifen sensitivity, and DNA reversion
10. Gene analysis might explain ethnic differences in sensitivity to chemotherapy in lung cancer
11. Lung cancer-derived EGFR mutants exhibit intrinsic differences in inhibitor sensitivity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2020)... Mass. (PRWEB) , ... June 24, 2020 , ... ... of cloud-based enterprise software and software-driven clinical data services that accelerate drug development, ... for low-dose selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. This ...
(Date:6/23/2020)... ... 22, 2020 , ... The field of quantitation of large molecules or proteins ... this area. However, the use of mass spectrometry in this field has gained a ... “How do you choose which approach to use (LBA or MS)?” In many ...
(Date:6/19/2020)... ... ... The director of stem cell biotechnology company Asymmetrex , Dr. James L. ... have easier access to stem cell counting, they will soon make it a routine ... weekend in the U.S., Asymmetrex is offering free tissue stem cell counting at its ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... WESTMINSTER, Colo. (PRWEB) , ... ... ... providers of expert tissue data insights, today announced that the launch of ... PD-L1 results along with data about the tumor microenvironment (TME). , “Flagship’s ...
(Date:6/28/2020)... JOSE, Calif. (PRWEB) , ... June 25, 2020 ... ... globe, researchers are racing to develop a vaccine or drug treatment. In an ... Recursion has publicly released the world’s largest imaging dataset portraying therapeutic ...
(Date:6/28/2020)... ... June 26, 2020 , ... The ... today announced its strong opposition to the recently introduced bicameral Facial Recognition ... ban on most federal use of nearly all biometric and related image analytics ...
(Date:6/23/2020)... ... June 23, 2020 , ... DeCurtis Corporation, the ... today that Derek Fournier has been appointed CEO and President. Founder and former ... immediately. , “DeCurtis Corporation has been on an incredible journey for the ...
Breaking Biology Technology:
Cached News: