HOME >> BIOLOGY >> NEWS
Increasing norepinephrine stabilizes breathing patterns in a mouse model of Rett Syndrome

Grard Hilaire of the National Center for Scientific Research (CNRS), Laurent Villard of the French National Institutes of Health (INSERM) and Jan-Marino Ramirez of the University of Chicago and colleagues report in the December 14th, 2005 issue of the Journal of Neuroscience that the breathing disturbances in a mouse model of Rett Syndrome originate, at least in part, from a deficiency in norepinephrine and serotonin in a specific brain region called the medulla. This work was funded in part by the Rett Syndrome Research Foundation (RSRF).

Rett Syndrome (RTT) is a severe neurological disorder diagnosed almost exclusively in girls. Children with RTT appear to develop normally until 6 to 18 months of age, when they enter a period of regression, losing speech and motor skills. Most develop repetitive hand movements, seizures and extreme motor control problems. Irregular breathing patterns characterized by intermittent breath holding, hyperventilation and air swallowing are a particularly devastating symptom of the disorder. In some cases the irregular breathing can lead to death due to sudden respiratory arrhythmia. It is worthwhile to note that individuals with drastic respiratory alterations can spontaneously display transient periods of normal breathing and that breathing can normalize during sleep. RTT leaves its victims profoundly disabled, requiring maximum assistance with every aspect of daily living. There is no cure.

At birth, the mouse model of RTT exhibits typical breathing and normal content of norepinephrine in the medulla. The medulla is a section of the brainstem that is responsible for autonomic function (all the processes in the body that we take for granted like breathing, digestion, cardiac function, temperature control). Between one and two months of age, the mice displayed breathing disturbances that worsened until fatal respiratory arrest at about two months of age. The breathing disturbances were highly variable from mouse to mous
'"/>

Contact: Monica Coenraads
monica@rsrf.org
203-445-9233
Rett Syndrome Research Foundation
13-Dec-2005


Page: 1 2 3

Related biology news :

1. Increasing reproductive tourism in Europe is a safety valve that promotes peaceful coexistence
2. Ritalin packs punch by elevating norepinephrine, suppressing nerve signal transmissions
3. Training breathing muscles improves swimming muscles performance
4. Early treatment prevents lasting breathing problems in some premature babies
5. Vampire bats recognise their preys breathing
6. Short-term yoga training expands breathing and lung capacity in young, healthy adults
7. Prenatal nicotine exposure reduces breathing response of newborns...
8. Preparing for flu pandemic: Pall breathing filters can help protect patients, healthcare workers
9. Univ. of Chicago scientists find potential cause of breathing problems in Rett Syndrome children
10. Children who stop breathing during sleep show brain damage
11. How exactly does the brain control breathing?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... 05, 2020 , ... Regenative Labs has received approval from the Centers for ... them the first Wharton’s jelly allografts to be assigned a Q code and be ... the first Wharton’s jelly allograft product to be recognized as a 361 HCT/P by ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to lead ... near term focus on Type 2 diabetes and associated comorbidities. , Justin brings ... areas and classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ ...
(Date:7/18/2020)... ... , ... Commercial launch readiness is a critical stage in a product life ... vaccine, the global economic downturn will only increase price pressures overall for the industry. ... full value from every product launch is critical. However, history shows that only a ...
Breaking Biology News(10 mins):
(Date:9/3/2020)... LOUIS, Mo. (PRWEB) , ... September 03, 2020 ... ... 10-11, 2020, will feature 15+ expert speakers to present updates on their latest ... will highlight innovative technologies and their impact in clinical diagnostics and therapeutic development, ...
(Date:9/1/2020)... ... September 01, 2020 , ... ... diagnostics companies, has announced the placement of Julianne Averill , CPA, as ... leading all financial operations and implementing key business strategies to accelerate Alveo’s growth ...
(Date:8/31/2020)... Del. (PRWEB) , ... August 29, 2020 , ... ... a new Animal Nutrition manufacturing capability in Wuxi, China. The new plant operation ... global quality standards and advanced technology. , “This facility will improve the ...
(Date:8/15/2020)... ... ... True Terpenes , the leading platform for terpene innovation, research and ... the medical potential of terpenes and the potential entourage effect , where the ... focused on expanding the recently launched line of effects-based terpenes - Terpology by ...
Breaking Biology Technology:
Cached News: