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Increasing norepinephrine stabilizes breathing patterns in a mouse model of Rett Syndrome

ze the breathing rhythm by applying norepinephrine

"Ongoing experiments are now aimed at testing different pharmacological tools in vivo, in order to specifically stimulate the norepinephrine-producing neurons still present in the medulla of the RTT mice. Preliminary data are very encouraging. The Villard lab currently plans to follow up on pharmacological interventions both in mice and in humans in collaboration with clinicians from the Children's Hospital in Marseille," said Jean-Christophe Roux, the RSRF fellow and co-first author of the paper.

"I am gratified that RSRF was able to provide funding for this important research and I am encouraged that it will lead to much needed treatments for children and adults struggling with extreme breathing issues", said Monica Coenraads, co-founder and Director of Research for RSRF.


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Contact: Monica Coenraads
monica@rsrf.org
203-445-9233
Rett Syndrome Research Foundation
13-Dec-2005


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