HOME >> BIOLOGY >> NEWS
Individual differences in taste perception directly related to genetic variation in taste receptors

Philadelphia, PA -- Why do brussels sprouts taste bitterly repellent to one person and bland - or even delicious - to the next?

A study published in the February 22 issue of Current Biology confirms the influential role of genetics in determining the wide range of human sensitivity to taste, ultimately impacting how we each perceive the world in a slightly different way.

"Each human carries their own distinctive set of taste receptors which gives them a unique perception of how foods and medicines taste," explains Monell Chemical Senses Center psychophysicist Paul Breslin, PhD, who shares first authorship and is a corresponding contributor for the study. "This paper shows that a single gene codes for multiple forms of a taste receptor, with each form having a differing sensitivity to taste compounds. Further, a person's perceptual sensitivity to these bitter tasting compounds corresponds strikingly well with their genetically-determined receptor sensitivity."

In the paper, researchers at the Monell Center and collaborating institutions related individual perception of the bitter-tasting compounds PTC and PROP to variation in a bitter taste receptor gene known as hTAS2R38.

The researchers cloned two forms (haplotypes) of the hTAS2R38 gene and expressed the corresponding receptors in a cell culture. The two haplotypes, known as PAV and AVI, vary with respect to amino acid substitutions encoded at certain positions on the taste receptor protein.

In the cell culture experiments, small amounts of the bitter compounds activated cells expressing the PAV form of the receptor, whereas cells expressing the AVI form were unresponsive to the same compounds. Cells expressing other haplotypes (eg PVI, AAI or AAV) had intermediate sensitivity to the bitter compounds.

Other experiments examined bitterness perception in human subjects. People with the PAV form of the hTAS2R38 gene were most sensitive to the bitter taste of PROP a
'"/>

Contact: Paul Breslin
breslin@monell.org
215-898-5021
Monell Chemical Senses Center
21-Feb-2005


Page: 1 2 3

Related biology news :

1. Individual differences in a clock gene predict decline of performance during sleep deprivation
2. Individuals and populations differ in gene activity levels, not just genes
3. Individuals with genetic conditions twice as likely to report health insurance denial
4. Individual taste receptor variations determine classic PTC bitterness perception
5. Individualized medicine emerging from gene-environment studies
6. Study finds gender differences in renal and other genes contributing to blood pressure
7. Sugar and spice and everything nice: Health differences in newborn girls and boys
8. New tumor markers -- Spot the differences
9. Brains reflect sex differences
10. Gene analysis might explain ethnic differences in sensitivity to chemotherapy in lung cancer
11. Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... Modality Solutions, a biopharmaceutical ... annual Inc. 5000 list. The list is the most prestigious ranking of the nation’s ... and for this year’s list, reported three-year revenue growth of 71 percent. , ...
(Date:8/21/2020)... ... August 20, 2020 , ... NDA Partners Chairman ... Operations executive with expertise in clinical trial planning and feasibility, regulatory inspection readiness, ... Consultant. Throughout his career, Mr. Movahhed has helped design and manage oncology, neurology, ...
(Date:8/5/2020)... ... ... Regenative Labs has received approval from the Centers for Medicare & Medicaid Services ... jelly allografts to be assigned a Q code and be approved for application directly ... allograft product to be recognized as a 361 HCT/P by CMS regulated under 21CFR ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... LORTON, Va. (PRWEB) , ... July 08, 2020 ... ... laboratory testing services and products, announces a significant expansion of laboratory operations through ... robust collection for agencies implementing testing programs. , Bode-CARES provides ...
(Date:7/10/2020)... ... July 09, 2020 , ... Sentien Biotechnologies, Inc., a ... of Allen R. Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. ... lead product, SBI-101. Dr. Nissenson serves as an Emeritus Professor of Medicine ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... date growth of 40% in 2020, despite many obstacles created as a result ... to increase revenue for its partnered medical practices and medical manufacturers by expanding ...
(Date:6/28/2020)... ... June 25, 2020 , ... The Indoor Lab, a leading ... Space™ for businesses of all types to ensure cleanliness, distancing and occupancy with its ... A Safe Space™ enabled business will provide a health performance index system that scores ...
Breaking Biology Technology:
Cached News: