HOME >> BIOLOGY >> NEWS
Inflammation markers identify fatigue in breast cancer survivors

PHILADELHPIA -- Researchers at the University of California, Los Angeles have defined conditions associated with disabling fatigue that persists for years in almost a third of breast cancer survivors, according to a study in the May 1 issue of Clinical Cancer Research.

The key to their fatigue stems from responses within their immune systems.

"These studies identify a biological basis for persistent fatigue in cancer survivors that is implemented by inflammation," said Michael Irwin, M.D., director and senior research scientist, Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience, and the UCLA Jonsson Cancer Center.

"We have detected a biological marker that is a composite of two immune response elements," he added. "This biomarker identifies and can predict which women have long term persistent fatigue.

"These findings point the way for development of novel treatment strategies that decrease this inflammatory response and thwart the fatigue that these patients endure."

One component of the marker, Dr. Irwin explained, is a measure of the amount of interleukin-6 receptor (IL-6R) free-floating in the blood of breast cancer survivors compared to the amount of that receptor remaining on the membranes of specific blood cells where the receptor normally is found and functions within the immune response.

The IL-6R is usually embedded on the surface membrane of white blood cells, or monocytes. In some survivors, however, many of the IL-6R are shed from the monocytes and are soluble within the blood plasma. Those free-floating receptors can still bind to circulating cytokine IL-6, Dr. Irwin noted, and in that form have the potential to interact with cells that normally don't respond to cytokine/receptor activation such as brain cells that may regulate fatigue sensation.

IL6 is a biological chemical that helps drive initial immune responses within people. "IL-6 contribut
'"/>

Contact: Russell Vanderboom, Ph.D.
vanderboom@aacr.org
215-440-9300
American Association for Cancer Research
1-May-2006


Page: 1 2

Related biology news :

1. Inflammation may cause preterm labor and fetal deaths
2. Inflammation is at the origin and progression of diseases such as diabetes or cancer
3. Targeting tau: Inflammation study suggests new approach for fighting Alzheimers
4. Inflammation and drugs to control this activity studied in a variety of tumors sites
5. Research aims to identify markers for menopausal women at risk for deadly blood clot
6. Contributing membership in the biomarkers consortium surges to 30 companies and nonprofits
7. New tumor markers -- Spot the differences
8. Tumor vessels identified by unique molecular markers
9. Jaap Sinninghe Damst awarded the Vernadsky Medal for innovative use of biomarkers
10. Pancreatic cancer markers identified, may predict survival
11. Genes and biomarkers that allow doctors to choose the right therapy for the right patient

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2019)... ... February 01, 2019 , ... uBiome, ... Testing Laboratories by A2LA, which establishes requirements for medical laboratories to demonstrate competence ... is already CLIA-licensed as well as College of American Pathologists (CAP)-accredited, a designation ...
(Date:1/25/2019)... (PRWEB) , ... January 24, 2019 , ... ... the results of its 2019 Association Industry Survey. The report indicates membership growth ... email between mid-November to early December 2018, received responses from over 500 association ...
(Date:1/21/2019)... ... January 20, 2019 , ... Energetiq Technology, a world leader ... Photonics, at the SPIE BIOS and SPIE Photonics West events taking place in San ... in booth #8526 at Bios and in booth #941 at Photonics West. There will ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... ... January 30, 2019 , ... ... genomics, has awarded microbiome research support in study design, planning, sample collection, and ... by Dr. Marc D. Cook, PhD, to study the interactions between gut microbial ...
(Date:1/24/2019)... ... 2019 , ... Controlled Contamination Services is pleased to announce three exciting new ... valuable new team members will support its growing operation across the US and will ... its business. This addition will enable CCS to widen its reach and provide enterprise ...
(Date:1/24/2019)... (PRWEB) , ... January 23, 2019 , ... ... in microbial genomics, has awarded microbiome research support in study design, planning, sample ... Faculty of Medical Sciences, St. Augustine Campus in Trinidad led by Dr. Elaine ...
(Date:1/20/2019)... ... January 17, 2019 , ... Consumers are ... exclusive purview of physicians. That's changing as many services now exist for patients ... laboratory testing market totaled $208 million in 2018, according to Kalorama Information’s new ...
Breaking Biology Technology:
Cached News: