HOME >> BIOLOGY >> NEWS
Information processing in the central nervous system: the signalling system controlling movement

Research by Renee Theiss, Jason Kuo and C J Heckman, which has just been published in The Journal of Physiology, throws light on how information is processed in the Central Nervous System (CNS) to drive movement. The findings are relevant to understanding mechanisms underlying movement and disorders such as spinal cord injury and motor neurone disease (ALS).

Interneurones in the spinal cord integrate command signals from the brain, with information from the senses, and their own internal pattern generating activities to send appropriate instructions to motorneurones controlling movement. Spinal interneurones exhibit a remarkable variety of firing patterns in response to a pulse of injected current, with important implications for information processing. These patterns range from repetitive to delayed, to bursting and to single spiking.

In the ventral spinal cord, interneurones process both motor commands and sensory inputs. Steady firing interneurones integrate these inputs, while bursting neurons may emphasize input variations and single spiking neurons probably serve as coincidence detectors. Although these different processing modes suggest a diversity in ion channels, Robert Lee (now at Emory University) and C J Heckman hypothesized that a small component of the total current mediated by sodium channels plays a critical role in determining firing patterns. This component is persistent instead of transient and is essential for action potential initiation during prolonged input.

The research by Theiss et al. on slices of spinal cord taken from rats indicates that reducing persistent sodium current in ventral interneurones converted both steady firing and bursting patterns into a single spike pattern, and thus its modulation may provide the CNS with the capacity to mediate dramatic changes in neural computations. This result is an important step forward in our understanding of neuronal processing and should lead to
'"/>

Contact: Melanie Thomson
melanie.thomson@oxon.blackwellpublishing.com
44-018-654-76270
Blackwell Publishing Ltd.
14-Apr-2007


Page: 1 2

Related biology news :

1. Information on bird flu cases poorly recorded, scientists say
2. Genetic Association Information Network announces genotyping awards for 6 common diseases
3. New phase for Global Biodiversity Information Facility
4. Information & communications technologies key to sustainable development in Africa: UNU
5. Molecular motors may speed nutrient processing
6. Study shows response to financial loss parallels brains processing of pain
7. UCLA identifies new molecule involved in the bodys processing of dietary fat
8. Newly discovered platform for processing dietary fat
9. Iowa State researchers improve soy processing by boosting protein and sugar yields
10. St. Josephs provides tissue processing services to researchers in hopes of finding a cure
11. MicroRNA processing and cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: