HOME >> BIOLOGY >> NEWS
Initial sensor for p53 tumor-suppressing pathway identified

PHILADELPHIA - DNA breaks from radiation, toxic chemicals, or other environmental causes occur routinely in cells and, unless promptly and properly repaired, can lead to cancer-causing mutations. When the breaks cannot be repaired, and the cell is vulnerable to becoming cancerous, critical backup protection governed by the p53 protein kicks in. This protein is the end of the line in a vital signaling cascade that triggers cells with fatally damaged DNA to self-destruct so that they cannot cause cancer.

The importance of the p53 pathway in preventing cancer cannot be overstated. Scientists know, for example, that in the majority of human cancers the p53 pathway has been disabled. Despite the crucial nature of the p53 tumor-suppressor pathway, the answer to a central question has evaded researchers for years: How is the p53 pathway alerted to the presence of DNA breaks in the cell in the first place? If p53 lies at the end of the line in this pathway, what molecule is at the front, and how does it do its job?

In a new study led by researchers at The Wistar Institute, the sensor protein that identifies DNA breaks and activates the p53 cell-death program has been identified. Additionally, structural analysis of the protein and its interactions with DNA has revealed the specific mechanism by which the protein detects the breaks. The study will be published November 3 in the advance online edition of the journal Nature.

"We had been studying this protein for some time, and we knew it was important in the cellular response to DNA breaks," says Thanos D. Halazonetis, D.D.S., Ph.D., a professor in the gene expression and regulation program at The Wistar Institute and senior author on the Nature study. "Now, we know it is the initial sensor for the p53 tumor-suppressor pathway - it is responsible for detecting DNA breaks - and we also have a good idea how it works."

According to Halazonetis, the protein, known as 53BP1, recognizes a molecular s
'"/>

Contact: Franklin Hoke
hoke@wistar.upenn.edu
215-898-3716
The Wistar Institute
3-Nov-2004


Page: 1 2

Related biology news :

1. Disabling a sensory organ prompts female mice to act like male mice
2. A sensory organ, not the brain, differentiates male and female behavior in some mammals
3. Space-borne sensors help Africa tackle water shortage problems
4. Nanotechnology helps scientists make bendy sensors for hydrogen vehicles
5. Magnetic computer sensors may help study biomolecules
6. Biosensor sniffs out explosives
7. Carnegie Mellon University research shows how sensory-deprived brain compensates
8. Flexible electronics could find applications as sensors, artificial muscles
9. New sensor detects gaseous chemical weapon surrogates in 45 seconds
10. Microscopic sea creatures provide foundation for gas sensors and other devices
11. Biologically inspired sensors can augment sonar, vision system in submarines

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... , June 15, 2017  IBM (NYSE: IBM ) ... international tech event dedicated to developing collaboration between startups and ... on June 15-17. During the event, nine startups will showcase ... value in various industries. France ... the international market, with a 30 percent increase in the ...
(Date:5/16/2017)... N.J. , May 16, 2017  Veratad Technologies, ... provider of online age and identity verification solutions, announced ... K(NO)W Identity Conference 2017, May 15 thru May 17, ... Regan Building and International Trade Center. ... the globe and in today,s quickly evolving digital world, ...
(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... CALIF. (PRWEB) , ... October 10, 2017 , ... San ... part of its corporate rebranding initiative announced today. The bold new look is ... reach, as the company moves into a significant growth period. , It will also ...
(Date:10/10/2017)... Oct. 10, 2017 International research firm Parks Associates ... speak at the TMA 2017 Annual Meeting , October 11 in ... the residential home security market and how smart safety and security products ... Parks Associates: Smart ... "The residential security market ...
(Date:10/9/2017)... SAN DIEGO , Oct. 9, 2017 /PRNewswire/ ... a biological mechanism by which its ProCell stem ... of critical limb ischemia.  The Company, demonstrated that ... the amount of limbs saved as compared to ... of the molecule HGF resulted in reduction of ...
(Date:10/9/2017)... Texas (PRWEB) , ... October ... ... study published on October 5, 2017, in the medical journal, Epilepsia, Brain ... with the gold standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) ...
Breaking Biology Technology:
Cached News: