Insects and mammals share common fat-building pathway, study suggests

When it comes to gaining fat, insects and mammals may have something in common, researchers report in the Jan. 11, 2006, Cell Metabolism. The study finds that the so-called hedgehog (Hh) signaling pathway--an ancient suite of genes involved in determining the fates of many cell types--might also play an important role in fat formation in both flies and mice. The findings are the first to show a conserved effect of genes on fat storage from insects to mammals, according to the researchers.

The study results further suggest that the Hh pathway in mammals determines whether adult stem cells are fated for fat or bone. The findings suggest that drugs that target the Hh pathway might prove useful for the treatment of osteoporosis, diabetes, obesity, and lipodystrophy, a disease characterized by the absence of fat, said the researchers. The findings might also explain common traits normally associated with aging, they suggest.

"As we age, two striking things tend to happen almost across the board--our bones become thinner and we gain fat," said senior author, Jonathan Graff of the University of Texas Southwestern Medical Center. "Our findings are consistent with the idea that hedgehog signaling may diminish as we get older. Drugs that stimulate the pathway could possibly help to reverse or prevent this trend, building stronger bones while reducing fat."

The researchers found that flies in which the Hh pathway in the fat bodies was overactive gained less fat than normal. Conversely, treatments that blocked the action of the Hh pathway led to an increase in the insects' fat stores.

To see whether the same pattern might hold in mammals, the team then looked to the mouse. The animals' fat cells indeed expressed genes involved in the Hh pathway. In mouse cells, treatment with an Hh protein blocked the changes normally associated with the generation of fat, while methods that blocked Hh activity caused an increase in fat.

Moreover, they f

Contact: Heidi Hardman
Cell Press

Page: 1 2

Related biology news :

1. Insects to solve crimes
2. Insects cultivate antibiotic-producing bacteria in their antennae
3. Koshland Science Museum Program: A Look at the World of Insects
4. Insects that produce males from unfertilized eggs reveal a surprising cellular feat
5. Insects develop resistance to engineered crops
6. Insects, viruses could hold key for better human teamwork in disasters
7. Insects implicated in the evolution of new human infectious diseases
8. A sensory organ, not the brain, differentiates male and female behavior in some mammals
9. Robust time estimation reconciles views of the antiquity of placental mammals
10. The delayed rise of present-day mammals
11. Dinosaur extinction didnt cause the rise of present-day mammals, claim researchers

Post Your Comments:

(Date:11/10/2015)... YORK , Nov. 10, 2015 ... to behavioral biometrics that helps to identify and ... fraud. Signature is considered as the secure and ... the identification of a particular individual because each ... more accurate results especially when dynamic signature of ...
(Date:10/29/2015)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, is pleased to announce that it has been ... one of only three finalists for a 2015 ... Growing" category. The Tekne Awards honor Minnesota ... innovation and leadership. iMedNet™ eClinical ...
(Date:10/29/2015)... Connecticut , October 29, 2015 ... a biometric authentication company focused on the growing ... smart wallet announces that StackCommerce, a leading marketplace ... be featuring the Wocket® smart wallet on StackSocial ... NXTD ) ("NXT-ID" or the "Company"), a biometric ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... , Nov. 30, 2015  AbbVie, is introducing ... focuses on a daily routine for managing the life-long ... medication can affect the way the body absorbs it ... their a daily routine are important. The goal of ... patients better manage their hypothyroidism by establishing a daily ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... integration with MarkLogic, the Enterprise NoSQL database platform provider, creating a seamless ... , Smartlogic’s Content Intelligence capabilities provide a robust set of semantic tools ...
(Date:11/27/2015)... , Nov. 27, 2015 /PRNewswire/--  Mallinckrodt plc (NYSE: ... today that it has closed the sale of its ... Guerbet (GBT- NYSE Euronext) in a transaction valued at ... manufacturing facilities and a total of approximately 1,000 employees ... St. Louis area. This entire ...
(Date:11/26/2015)... 26, 2015 ... Accutest Research Laboratories, a leading independent ... (CRO), has formed a strategic partnership ... Temple Health for joint work on ... http://photos.prnewswire.com/prnh/20151126/10135429 ) , --> ...
Breaking Biology Technology:
Cached News: