HOME >> BIOLOGY >> NEWS
Insects and mammals share common fat-building pathway, study suggests

When it comes to gaining fat, insects and mammals may have something in common, researchers report in the Jan. 11, 2006, Cell Metabolism. The study finds that the so-called hedgehog (Hh) signaling pathway--an ancient suite of genes involved in determining the fates of many cell types--might also play an important role in fat formation in both flies and mice. The findings are the first to show a conserved effect of genes on fat storage from insects to mammals, according to the researchers.

The study results further suggest that the Hh pathway in mammals determines whether adult stem cells are fated for fat or bone. The findings suggest that drugs that target the Hh pathway might prove useful for the treatment of osteoporosis, diabetes, obesity, and lipodystrophy, a disease characterized by the absence of fat, said the researchers. The findings might also explain common traits normally associated with aging, they suggest.

"As we age, two striking things tend to happen almost across the board--our bones become thinner and we gain fat," said senior author, Jonathan Graff of the University of Texas Southwestern Medical Center. "Our findings are consistent with the idea that hedgehog signaling may diminish as we get older. Drugs that stimulate the pathway could possibly help to reverse or prevent this trend, building stronger bones while reducing fat."

The researchers found that flies in which the Hh pathway in the fat bodies was overactive gained less fat than normal. Conversely, treatments that blocked the action of the Hh pathway led to an increase in the insects' fat stores.

To see whether the same pattern might hold in mammals, the team then looked to the mouse. The animals' fat cells indeed expressed genes involved in the Hh pathway. In mouse cells, treatment with an Hh protein blocked the changes normally associated with the generation of fat, while methods that blocked Hh activity caused an increase in fat.

Moreover, they f
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
10-Jan-2006


Page: 1 2

Related biology news :

1. Insects to solve crimes
2. Insects cultivate antibiotic-producing bacteria in their antennae
3. Koshland Science Museum Program: A Look at the World of Insects
4. Insects that produce males from unfertilized eggs reveal a surprising cellular feat
5. Insects develop resistance to engineered crops
6. Insects, viruses could hold key for better human teamwork in disasters
7. Insects implicated in the evolution of new human infectious diseases
8. A sensory organ, not the brain, differentiates male and female behavior in some mammals
9. Robust time estimation reconciles views of the antiquity of placental mammals
10. The delayed rise of present-day mammals
11. Dinosaur extinction didnt cause the rise of present-day mammals, claim researchers

Post Your Comments:
(Date:7/31/2014)... genes to the earliest common ancestor of butterflies ... an extensive "Tree of Lepidoptera" in the first ... , Among the study,s more surprising findings: Butterflies ... to large ones, which completely changes scientists, understanding ... that some insects once classified as moths are ...
(Date:7/31/2014)... It has long been known that biomass burning ... savannah as a ritual , slash-and-burn agriculture and ... public health. , But until the release of ... Environmental Engineering Professor Mark Z. Jacobson, the degree ... , Jacobson,s research, detailed in a paper published ...
(Date:7/31/2014)... (HPV-023; NCT00518336) shows the sustained efficacy, immunogenicity ... (HPV) vaccine Cervarix. Women vaccinated with the ... than nine years, and vaccine efficacy (VE) ... the longest follow-up report for a licensed ... the full paper. , HPV and ...
Breaking Biology News(10 mins):UF study advances 'DNA revolution,' tells butterflies' evolutionary history 2UF study advances 'DNA revolution,' tells butterflies' evolutionary history 3Stanford professor finds that wildfires and other burns play bigger role in climate change 2Stanford professor finds that wildfires and other burns play bigger role in climate change 3Stanford professor finds that wildfires and other burns play bigger role in climate change 4Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 2Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 3
(Date:7/31/2014)... 31, 2014 Although RNA-Sequencing is ... first transcriptome-wide analyses appearing around 2008, RNA-Sequencing has ... RNA measurement. In the last several years, assays ... work with smaller input amounts, process degraded RNA, ... samples). On the bioinformatics side, there have been ...
(Date:7/31/2014)... 2014   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade hypothermic storage and ... shipping products for cells and tissues, today announced ... will be released on Thursday, August 7, 2014, and ... live webcast at 4:30 p.m. ET that afternoon. Management ...
(Date:7/31/2014)... July 31, 2014 The Kidney Cancer Association ... its monthly news magazine, Kidney Cancer News. , Bill ... on a website maintained by an international news organization. When ... increase in viewers.” , This month’s program highlights news of ... analyzed in a recent study. Kidney Cancer News also ...
(Date:7/31/2014)... AZ (PRWEB) July 31, 2014 Sales ... availability of its online sales training course – ... improve their sales performance. , Drawn from proven sales ... 500 companies, Mastering the Complex Sale online sales training ... to anyone who has face-to-face contact with customers, like ...
Breaking Biology Technology:The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2BioLife Solutions to Report Financial Results for Second Quarter 2014 and Provide Business Update on August 7, 2014 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 3
Cached News: