HOME >> BIOLOGY >> NEWS
Insight into JAK/STAT

Dr. Norbert Perrimon and colleagues at Harvard Medical School (Boston, MA) have used a genome-wide RNAi screen in cultured Drosophila cells to identify novel regulators of the JAK/STAT signaling pathway. In a stunning example of the utility of cell-based RNAi analysis in a genetically tractable system, like fruit flies, the researchers identified 121 genes involved in the JAK/STAT pathway, including a key, and previously unidentified, negative regulator of the pathway. PTP61F emerged from the screen as the first protein tyrosine phosphatase to inhibit JAK/STAT signaling. Since the JAK/STAT pathway is conserved between insects and mammals, the authors speculate that many of the new genes that they have identified will turn out to be important to understanding the role of this pathway in both human immune disorders and tumorigenesis.


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
1-Aug-2005


Page: 1

Related biology news :

1. Insights into osteosarcoma in cats and dogs may improve palliative care
2. Insight into evolution of adaptive immunity boosted by sea urchin genome sequencing
3. Insights into honey bee sex gene could bring sweet success in breeding
4. Insights into activity-dependent neuronal growth through RSRF-supported research
5. Symposium Environmental Change in Siberia -- Insights From Earth Observation and Modeling
6. Yale technology spins out varicose vein device company: Vascular Insights, LLC
7. Insight into our sight: A new view on the evolution of the eye lens
8. Insight into the processes of positive and negative learners
9. Insight into cell metabolism will help interpret PETs, MRIs
10. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
11. Insight into DNAs weakest links may yield clues to cancer biology

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2019)... Va. (PRWEB) , ... February 11, 2019 , ... ... forensic DNA analysis products and services, announced a new forensic genealogy service offering ... (FGS) combines advanced DNA testing and genealogy to develop ancestral relationships between ...
(Date:2/2/2019)... ... January 31, 2019 , ... Pharmica Consulting ... clinical operations executives and focusing on all facets of clinical trial planning and ... portfolio management, resource management, patient engagement, and more. , “We have attended ...
(Date:1/30/2019)... ... January 30, 2019 , ... ... high-impact life science and biotechnology companies, announced today that it will host ... disease-focused venture funds to discuss their investment philosophies, explain their fund and ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... , ... January 30, 2019 , ... ... microbial genomics, has awarded microbiome research support in study design, planning, sample collection, ... led by Dr. Marc D. Cook, PhD, to study the interactions between gut ...
(Date:1/24/2019)... ... , ... Outsourcing trials to contract research organizations (CRO) can ... creation and management generally requires manual effort. Additionally, each vendor organizes tasks and ... can ultimately lead to study start delays and change orders because tasks were ...
(Date:1/20/2019)... ... January 17, 2019 , ... The American Society of Gene & ... Education program , a new initiative for 2019. Designed by ASGCT committee volunteers in ... inform patients, families, and the public on the status and promise of gene and ...
(Date:1/11/2019)... ... January 11, 2019 , ... ... the automated collection of donor blood. This advanced and intuitive medical device ... unit incorporates the functionality needed for the busiest donor stations with new-to-the industry ...
Breaking Biology Technology:
Cached News: