HOME >> BIOLOGY >> NEWS
Insight into natural cholesterol control suggests novel cholesterol-lowering therapy

New work reported in the March issue of Cell Metabolism has provided insight into a key mechanism by which cells limit cholesterol synthesis. The finding suggests a novel approach to the development of cholesterol-lowering drugs that may boost the effect of statins, one of the most prescribed cholesterol inhibitors, according to researchers at the University of Texas Southwestern Medical Center.

Cells obtain cholesterol, an important component of cell membranes, by building it internally or by taking it up from the bloodstream. The cholesterol-building process involves more than 25 enzymes, including one called HMG CoA reductase, and many layers of regulatory control, said Russell DeBose-Boyd, senior author of the study.

Scientists have long known that cells respond to a high cholesterol diet by shutting down its internal synthesis, he explained. However, the molecular mechanisms by which cholesterol and other related compounds exert that self-control have only more recently begun to emerge.

The researchers now demonstrate that lanosterol--an intermediate compound in the synthetic pathway--mediates feedback control over the rate of cholesterol production by stimulating the degradation of cholesterol-building reductase. The availability of reductase, which functions early in the synthetic process, largely determines the rate of cellular cholesterol production, Debose-Boyd said.

When added to intact cells and cellular components in test tubes, lanosterol led other proteins to mark reductase for destruction by attaching a protein called ubiquitin in a process called ubiquitination. Ubiquitination is a common mechanism for stimulating protein degradation. Cholesterol itself had no such effect on reductase, even at much greater concentrations, they found.

"The current results demonstrate a direct role for lanosterol as a selective, physiologic regulator of reductase ubiquitination and degradation," said DeBose-Boyd. That effect wou
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2979
Cell Press
15-Mar-2005


Page: 1 2

Related biology news :

1. Insights into osteosarcoma in cats and dogs may improve palliative care
2. Insight into evolution of adaptive immunity boosted by sea urchin genome sequencing
3. Insights into honey bee sex gene could bring sweet success in breeding
4. Insights into activity-dependent neuronal growth through RSRF-supported research
5. Symposium Environmental Change in Siberia -- Insights From Earth Observation and Modeling
6. Yale technology spins out varicose vein device company: Vascular Insights, LLC
7. Insight into our sight: A new view on the evolution of the eye lens
8. Insight into the processes of positive and negative learners
9. Insight into JAK/STAT
10. Insight into cell metabolism will help interpret PETs, MRIs
11. Insight into DNAs weakest links may yield clues to cancer biology

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2019)... ... ... Project Lifeline – a community partnership and research program initiated ... use disorder (SUD) – will take center stage at the upcoming NACDS ... in preventing and treating opioid abuse in Blair County, Pennsylvania, will receive the NACDS ...
(Date:11/14/2019)... ... November 13, 2019 , ... NDA Partners Chairman Carl ... affairs and program management executive with more than 33 years of regulatory and ... firm as an Expert Consultant. , Robert Peterson has extensive experience in ...
(Date:11/12/2019)... ... November 12, 2019 , ... G5, the leader in real ... up to 25% and reduces cost-per-click by as much as 15%. An integral ... (MTA) to predict best advertising outcomes and automatically allocate daily ad investments across ...
Breaking Biology News(10 mins):
(Date:11/9/2019)... ... November 08, 2019 , ... ... use in pathology research, today announced the results of analyses examining the ... in the phase 3 selonsertib studies (STELLAR). Strong correlations were demonstrated between ...
(Date:11/5/2019)... ... November 04, 2019 , ... ... delivery technologies, development, and manufacturing solutions for drugs, biologics, gene therapies, and ... development technology, GPEx® Boost. The technology enhances Catalent’s proven GPEx expression platform ...
(Date:11/2/2019)... ... 2019 , ... A clinical trial usually involves many different ... principal investigators, supply chain managers, manufacturers, IRT, CRAs and so on. Lack of ... data, potentially leading to patient risk. , By having a single source of ...
(Date:10/30/2019)... S.D. (PRWEB) , ... October 30, 2019 , ... While ... of researchers and students at South Dakota School of Mines & Technology ... cells while leaving healthy cells alive. , If successful, the technique would prove ...
Breaking Biology Technology:
Cached News: