HOME >> BIOLOGY >> NEWS
'Insulator' helps silence genes in dormant herpes virus

(Philadelphia May 2, 2007) By adulthood, most people have suffered at least one bout of painful cold sores brought on by the Herpes simplex virus 1, also known as HSV-1. After the initial infection, the virus usually remains in the body, hiding out in nearby nerve cells where the victim's immune defenses cannot reach it, causing no symptoms at all.

In order to escape detection by the body's immune system, the latent virus works to silence genes that would cause it to replicate. In this dormant state, only a tiny fragment of the virus genome a single gene called the Latency-Associated Transcript gene (LAT) remains active. Scientists have long puzzled over the mechanism used to keep this small region of the genome going while nearby genes remain quiescent.

Now, scientists at The Wistar Institute have discovered a molecular mechanism that keeps HSV-1 activation restricted to a single gene for months or even years. The researchers have identified an "insulator" a stretch of DNA about 800 base pairs long that serves as a physical barrier between active and inactive regions of the virus genome. Base pairs are the nucleotides on each side of the rungs that connect the strands of the DNA ladder.

"By establishing an insulator in early latency, the Herpes virus can protect this one small region of the genome from silencing, allowing infected cells to survive," says study senior author Jumin Zhou, Ph.D., an associate professor at The Wistar Institute.

The findings, appearing in the May issue of the Journal of Virology, mark the first time an insulator has been identified in a virus and may lead to ways to develop strategies to manipulate the virus.

Insulators, also known as boundary elements, are DNA segments that work to prevent a gene from being influenced by the activation or repression of its neighbors. About a dozen different insulator elements have been identified in organisms as varied as yeast, fruit flies, an
'"/>

Contact: Franklin Hoke
hoke@wistar.org
215-898-3716
The Wistar Institute
2-May-2007


Page: 1 2 3

Related biology news :

1. Genetic variation helps to understand predisposition to schizophrenia
2. Link between sunspots, rain helps predict disease in east Africa
3. Taking a supplement of glycine helps prevent degenerative diseases such as arthrosis or osteoporosis
4. Progesterone therapy and preterm birth: More evidence helps identify women who can benefit
5. Nanotechnology helps scientists make bendy sensors for hydrogen vehicles
6. Preconditioning helps protect brains blood vessels from stroke
7. Manchester University helps with pharaoh DNA analysis
8. A spoonful of sugar helps your waistline go down
9. Study helps preserve Arctic whale, Eskimo subsistence hunt
10. Ethanol injection helps manage bone metastasis in thyroid cancer patients
11. Fusing imaging technologies creates synergy, helps diagnose heart disease accurately

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... Inc., a global expert in SoC-based imaging and computing solutions, has ... features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® ... be showcased during the upcoming Medtec Japan at Tokyo Big Sight ... Las Vegas Convention Center April 24-27. ... Click here for an image of the ...
(Date:4/13/2017)... Calif. , April 13, 2017 UBM,s ... York will feature emerging and evolving technology ... Both Innovation Summits will run alongside the expo portion ... speaker sessions, panels and demonstrations focused on trending topics ... largest advanced design and manufacturing event will take place ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... July 20, 2017 , ... VIC Technology Venture Development™ (VIC™), ... of directors. This addition continues to strengthen and diversify VIC’s board. , "We ... Chairman. “He is a highly accomplished business executive with a broad range of experience ...
(Date:7/18/2017)... ... July 18, 2017 , ... Nanomedical Diagnostics, a cutting-edge life ... launch of a new NTA biosensor chip for use with its label-free Agile ... of polyhistidine-tagged (His-tagged) molecules quickly and reliably. , “Recombinant proteins are an ...
(Date:7/18/2017)... Washington, DC (PRWEB) , ... July 18, 2017 ... ... for the Allotrope Framework, and has released the first phase of the Allotrope ... Bio-IT World’s Best Practices Awards were created to “not only elevate the critical ...
(Date:7/17/2017)... , ... July 17, 2017 , ... ... and analytical instruments announced the launch of its new line of Heavy-Duty Orbital ... shaker models (both analog and digital) for laboratory applications. These shakers are ...
Breaking Biology Technology:
Cached News: