HOME >> BIOLOGY >> NEWS
Insulin -- in need of some restraint?

LA JOLLA, CA Knocking out the gene for a peptide associated with insulin secretion protects mice against the harmful effects of a high-fat diet, report researchers at the Salk Institute for Biological Studies. Their findings, detailed in the Proceedings of the National Academy of Sciences, suggest that urocortin 3, a new peptide recently discovered in the insulin secreting cells of the pancreas, plays a role in the increased production of insulin in response to high caloric intake in animals.

"Many normal mice eventually develop some signs of type 2 diabetes as they age," explains Wylie Vale, Ph.D., who conducted the study in collaboration with Kuo-Fen Lee, Ph.D., both professors in the Clayton Foundation Laboratories for Peptide Biology. "Interestingly, the mutant mice missing the urocortin 3 gene did not develop the age-related insulin resistance and high blood sugar we observed in the normal control mice," adds Vale.

After initial experiments had shown the importance of ucocortin 3 for the secretion of insulin, the Salk researchers bred mice missing the gene for urocortin 3 and compared their metabolism to that of normal mice. When placed on a high caloric diet for three months, the mutant mice packed on the same amount of weight and, as expected, had lower insulin levels. But, to the researchers' surprise, they also had lower blood sugar, improved glucose tolerance curves and didn't develop the fatty livers their unaltered counterparts suffered from.

"It is possible that restraining the abnormally high levels insulin secretion, which occurs with high caloric intake may help to maintain insulin sensitivity and, thus, avoid some of the untoward consequences of the high food intake and weight gain," states first author Chien Li, the postdoctoral researcher who analyzed these mice and has since taken a faculty position at the University of Virginia.

Vale says the study reveals the "dark side" of high insulin production,
'"/>

Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
6-Mar-2007


Page: 1 2 3

Related biology news :

1. Insulin grown in plants relieves diabetes in mice; UCF study holds promise for humans
2. Insulin sensitizer also serves as energy-conserving signal to the brain
3. Insulin therapy shown to treat early experimental diabetic retinopathy
4. Insulin pathway component explains insulin resistance, age-associated metabolic syndrome
5. Insulin research builds on Nobel Laureates work
6. Insulin sensitivity gets a kick out of SOCS-7
7. Insulin spares intensive care patients from organ failure and death
8. Insulin pulses keep the liver lean

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... (PRWEB) , ... August 14, 2019 , ... Representatives with ... Convention and Exhibition Center in Boston. , “We help innovative projects connect with Chinese ... spokesperson for MyBioGate. , Guo went on to explain that as a part of ...
(Date:8/6/2019)... ... 2019 , ... A study released today in STEM CELLS ... for personalized medicine, especially when seeking treatments for children with heart failure. The ... cell donors and manipulation methods might yield the best therapies for these patients. ...
(Date:8/4/2019)... (PRWEB) , ... August 02, 2019 , ... Stay on ... biotech, medical device and food industries. Access to all webinars is free, so be ... relevant in your field! , Visit http://www.xtalks.com to see our upcoming webinars: ...
Breaking Biology News(10 mins):
(Date:7/17/2019)... , ... July 16, 2019 ... ... long-term strategic agreement for the development and manufacturing of Zolgensma® (onasemnogene abeparvovec-xioi), ... this collaboration, AveXis, a Novartis company, will have dedicated manufacturing space at ...
(Date:7/9/2019)... ... July 08, 2019 , ... Balluff ... Indicator was recognized as the 2019 Innovative Product of the Year which highlights ... awards were during Sensors Expo & Conference 2019, held this week ...
(Date:6/18/2019)... ... 2019 , ... Personalized Stem Cells, Inc (“PSC”), a human adipose-derived ... for use of a person’s own adipose-derived stem cells to treat their osteoarthritis. The ... This IND is the first of several planned clinical trials which will enable ...
(Date:6/11/2019)... Calif. (PRWEB) , ... June 10, 2019 , ... ... today announced IOPP will add 80 of its scientific journals to DeepDyve’s rental ... physics-related content to DeepDyve’s continually expanding library of more than 20 million articles, ...
Breaking Biology Technology:
Cached News: