HOME >> BIOLOGY >> NEWS
Insulin research builds on Nobel Laureate's work

Scientists have seen for the first time a key step in the complex molecular processes whereby pancreas cells release insulin into the bloodstream.

The breakthrough, which builds on earlier Nobel-Prize winning research, could have implications for the treatment of diabetes which is caused when not enough insulin is released by the pancreas to meet the body's demands.

The team of scientists from the University of Manchester, Charite University in Berlin, and the University of Heidelberg say the findings could also be important in understanding other diseases, as hormone and protein secretion is an important function of all types of cell.

"Large numbers of proteins, including hormones such as insulin, are constantly being produced by our cells and carry out essential functions in the body," explained Dr Martin Pool, based in Manchester's Faculty of Life Sciences.

"In order for them to work, these proteins have to be transported to the right place and it is this process of fundamental importance to all living organisms that we are interested in."

Dr Pool's work to be published in the highly respected journal Science is based on a 30-year-old hypothesis of how proteins are transported across cell membranes and directed to their correct location.

That hypothesis was devised and proven by Dr Gunter Blobel and led to him receiving the Nobel Prize in Physiology or Medicine in 1999.

But the Anglo-German team has taken Dr Blobel's investigations a step further as they have been able to physically see the processes at work using sophisticated electron microscopes.

"Previous work had provided a framework of how the system worked but we were limited to models and cartoons of how it might look and actually function," said Dr Pool.

"Visualising the structure using a technique called cryo-electron microscopy has confirmed that many of the earlier proposals of the model were in fact correct.

"This pr
'"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
5-May-2006


Page: 1 2

Related biology news :

1. Insulin grown in plants relieves diabetes in mice; UCF study holds promise for humans
2. Insulin sensitizer also serves as energy-conserving signal to the brain
3. Insulin therapy shown to treat early experimental diabetic retinopathy
4. Insulin -- in need of some restraint?
5. Insulin pathway component explains insulin resistance, age-associated metabolic syndrome
6. Insulin sensitivity gets a kick out of SOCS-7
7. Insulin spares intensive care patients from organ failure and death
8. Insulin pulses keep the liver lean
9. NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
10. Saudi Arabias KAUST names WHOI first research partner
11. Multinational research: protecting ecology means understanding people, too

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/19/2019)... ... August 19, 2019 , ... Since the microscope was ... two dimensional slices which are placed on microscope slides, stained and visualized by ... complicated features such as vasculature and thus researchers in the last few years ...
(Date:8/14/2019)... CITY, and MARTINSRIED, Germany (PRWEB) , ... August ... ... high-throughput antibody screening and characterization, announced today that they have opened a Customer ... platform has fueled the need for the new office. , The Munich CEC ...
(Date:8/14/2019)... ... 13, 2019 , ... Dr. Julie Reck of Veterinary Medical Center of Fort Mill ... first stem cell patient, her own geriatric Australian Shepherd, Simon, was treated in June 2019 ... to play but his body was weak, and he struggled to play fetch and other ...
Breaking Biology News(10 mins):
(Date:6/26/2019)... ... , ... Alice Branton today released research results from preclinical trials on the ... can prove to be beneficial for treating Hypomagnesemia. , The preclinical trial shows:, ... size , Over 142% increase in particle size , Over ...
(Date:6/11/2019)... , ... June 10, 2019 , ... ... its distribution network with the appointment of Biofeedback Tech Ltd as ... systems are an essential part of many therapeutic treatments and clinical assessment protocols ...
(Date:6/11/2019)... (PRWEB) , ... June 11, 2019 , ... ... of Personalized Stem Cells Inc. (PSC) , has announced that their GMP ... Health, Food and Drug Branch for manufacturing. This is an important milestone ...
(Date:5/31/2019)... , ... May 29, 2019 ... ... patent applications from the USPTO providing proprietary interest to our methodology, processes, ... SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including our proprietary ...
Breaking Biology Technology:
Cached News: