HOME >> BIOLOGY >> NEWS
Insulin sensitizer also serves as energy-conserving signal to the brain

A fat-derived protein known for its effects on the liver and skeletal muscle might also serve as an energy-conserving signal to the brain during periods of starvation, suggests a new study in the July issue of Cell Metabolism, a publication of Cell Press. The substance, known as adiponectin, acts on the brain to boost appetite and slow energy expenditure in an effort to maintain adequate fat stores during lean times, the researchers report.

Energy homeostasis may be mediated by both short-term regulators, such as gut hormones, and long-term regulators, said Takashi Kadowaki of the University of Tokyo. In this study, we identified, for the first time, a potential long-term regulator that allows energy to be stored efficiently, namely, adiponectin. The findings offer critical insight into adiponectins influence over the central nervous system and suggest that selective inhibition of the chemical in the brain may represent a novel therapeutic strategy for obesity and obesity-linked diseases, he added.

White adipose tissue (WAT) is a major site of energy storage and plays an important role in energy balance, the researchers said. It is also recognized as an important endocrine organ that secretes a number of biologically active signaling proteins, called adipokines. Adiponectin, an adipokine secreted exclusively by WAT, is present at relatively high concentrations in the circulation and has been shown to increase the bodys response to insulin. Studies have also suggested that decreased circulating levels of adiponectin in obesity and type 2 diabetes may contribute to the insulin resistance that characterizes both conditions.

In addition to its peripheral actions on the liver and skeletal muscle, adiponectin has also been reported to have central actions, Kadowaki said. Recently, however, it was reported that adiponectin is undetectable in human cerebrospinal fluid and does not cross the blood-brain barrier, leaving some doubt about its
'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
10-Jul-2007


Page: 1 2

Related biology news :

1. Insulin grown in plants relieves diabetes in mice; UCF study holds promise for humans
2. Insulin therapy shown to treat early experimental diabetic retinopathy
3. Insulin -- in need of some restraint?
4. Insulin pathway component explains insulin resistance, age-associated metabolic syndrome
5. Insulin research builds on Nobel Laureates work
6. Insulin sensitivity gets a kick out of SOCS-7
7. Insulin spares intensive care patients from organ failure and death
8. Insulin pulses keep the liver lean
9. A first -- Hebrew University scientist observes brain cell development in real time
10. Marine reserves could save coral reefs
11. When smell cells fail they call in stem cell reserves

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/24/2020)... ... , ... Shoreline Biome , a microbiome research company that develops tools ... will debut a novel new DNA isolation kit at the Miami Winter Symposium ... Prep kit, is a fast and easy-to-use kit designed for the efficient and unbiased ...
(Date:1/23/2020)... ... , ... GIOSTAR/HEAMGEN has developed and secured patented ... red blood cells are made utilizing a bioreactor that permits the production of ... the need for a human blood donor. GIOSTAR/HEAMGEN mature red blood ...
(Date:1/22/2020)... ... January 21, 2020 , ... ... cold chain operations, developing transport validation strategies, supporting global regulatory applications, and ... 5000 and the Houston Business Journal as a fastest growing company, and ...
Breaking Biology News(10 mins):
(Date:2/11/2020)... ... February 11, 2020 , ... ... solutions services in North America, today announced that the City of Fort Worth ... its biosolids management needs. Commencing in April of 2020, Synagro will assume operation ...
(Date:2/3/2020)... ... February 03, 2020 , ... ... Travel, Law Firm Travel, Technology Industry Travel and Biotech/Healthcare Industry Travel Indexes. , ... Index illustrates the following statistics:, Average airfare price ...
(Date:1/28/2020)... ... January 28, 2020 , ... Today, Salimetrics announced an addition ... Salivary Total Human IgG Assay Kit exemplifies Salimetrics’ 20+ year commitment ... can extend the accuracy and ease of use of salivary bioscience into infectious ...
(Date:1/24/2020)... ... 24, 2020 , ... The impact of new medicines, procedures, ... and clinical services during the first two decades of the 21st century have ... Slone Partners celebrates its 20th anniversary this year, its evolution as a ...
Breaking Biology Technology:
Cached News: