HOME >> BIOLOGY >> NEWS
Interdisciplinary grant to Yale: Creating nanodevices for delivery of vaccines

New Haven, Conn. -- A team of Yale biomedical engineers and cell biologists received a $1-million award from the National Science Foundation to develop "smart nanoparticles" for the delivery of vaccines.

Led by Tarek Fahmy, assistant professor of biomedical engineering, the team will apply the two-year, Nanoscale Interdisciplinary Research Team (NIRT) funding to develop a new class of nanomaterials with properties that mimic biological vectors like bacteria and viruses.

"While previous research has shown that safe, biocompatible materials can be engineered into nanoparticles that contain drugs or vaccines, we will develop new materials for vectors that interact specifically and predictably with cells," said Fahmy. "Our nanosystems will be designed to evade the normal barriers and stimulate antigen-presenting cells of the immune system."

The researchers propose to construct the "smart nanoparticle" vaccine delivery system using a simple, modular approach that can be easily modified to meet the requirements of any particular vaccine. They expect this approach to be safer and more effective than current methods of co-administering an adjuvant or delivering live attenuated or killed bacteria or viruses to amplify the immune response.

"We will specifically target antigen-presenting cells such as the dendritic cells that are uniquely responsible for initiating immune responses," said Ira Mellman, chair and Sterling Professor of Cell Biology. "Targeting antigens to dendritic cells is emerging as a powerful novel strategy for vaccination."

The researchers will also track the fate and biological activity of the "smart nanoparticles" in cultured de
'"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
27-Oct-2006


Page: 1 2

Related biology news :

1. Interdisciplinary team develops guidelines for treating severely injured patients
2. Gilbert Foundation and American Fed for Aging Research award grants on Alzheimers disease
3. Carnegie Mellons Peter Adams receives EPA research grant
4. New grants bolster efforts to generate faster and cheaper tools for DNA sequencing
5. $9M grant awarded to University of Cincinnati for bipolar disorder research
6. $9 million EPSCoR grant to foster integrated research
7. UT and Atom Sciences Collaborate on NIH grant to develop test for major african disease
8. VIB scientist receives major research grant
9. New amfAR research grants to optimize HIV treatment
10. Wright State scientist receives grant to help clean up polluted American harbors
11. Ancient Etruscans were immigrants from Anatolia, or what is now Turkey

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... 03, 2020 , ... Litmus Health , the research-ready ... of the company’s security practices has been completed. The assessment deemed Litmus infrastructure ... evaluation reviewed Litmus’ processes and systems, assessing them to see whether they adhere ...
(Date:8/23/2020)... , ... August 21, 2020 , ... ... Corporation has been published and is now available on the company’s global ... diffraction—serves the X-ray analysis community, presenting current news and crystallographic research. , ...
(Date:8/12/2020)... , ... August 11, 2020 , ... ... based in Princeton, NJ, have entered into license agreements with Housey Pharma’s HMI ... Both Roche and J&J have annual Research and Development spending in excess ...
Breaking Biology News(10 mins):
(Date:7/7/2020)... ... July 06, 2020 , ... R3 International is now offering stem cell therapy ... stem cells. Depending on the patient's condition, treatment may be offered IV, intrathecal or ... some form of Alzheimers dementia, and the incidence continues to increase as individuals live ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... procured purchasing contracts to its membership, recently named BioFit Engineered Products ... the opportunity to purchase ergonomic seating, cafeteria tables, book trucks and carts at ...
(Date:6/28/2020)... ... 25, 2020 , ... With the COVID-19 pandemic impacting millions ... In an effort to better understand the cellular responses to COVID-19, the digital ... portraying therapeutic compound effects from over 1,600 approved and referenced molecules on SARS-CoV-2-infected ...
(Date:6/23/2020)... ... 23, 2020 , ... Kerafast Inc. , developers of ... the availability of the Delta-G-VSV Pseudotyping System for coronavirus research applications. The system, ... SARS-CoV-2 viral entry and COVID-19 vaccine effectiveness at just biosafety level 2 (BSL-2) ...
Breaking Biology Technology:
Cached News: