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Intrinsic eye protein halts angiogenesis

"The standard paradigm has been the cornea is avascular because it has lots of anti-angiogenic molecules and it does," Balamurali Ambati said. "But knockdown of any of the other molecules does not cause blood vessels to enter the cornea. Knocking down SFLT-1 allows angiogenesis to take hold."

The next step, according to the researchers, is to test SFLT-1 in other areas of the body, encouraging tissues to produce the protein on their own.

"We want to know what it is in the cornea that produces so much of this protein which inhibits angiogenesis. With that knowledge we will be closer to fighting the growth of everything from vision-obscuring blood vessels in the eye to cancers," said Jayakrishna.


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Contact: Allison Elliott
allison.elliott@uky.edu
859-257-1754 x249
University of Kentucky
18-Oct-2006


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