HOME >> BIOLOGY >> NEWS
Invasion of the brain tumors

Gliomas are highly malignant and invasive tumors with tendrils that extend far from the primary tumor site, rendering conventional therapies ineffective and leading to an invariably poor prognosis. In a new study published online this week in the open-access journal PLoS Biology, Angela Johnston, Donna Senger, and colleagues at the University of Calgary injected immunocompromised mice with human gliomas and compared invasive cells (which left the primary tumor site) to noninvasive cells (which remained at the site of injection) in order to understand the molecular mechanisms underlying this invasive behavior. They identified the neurotrophin receptor p75NTR, which normally functions during development to induce neurite outgrowth and promote neuronal cell death, as an important regulator of glioma invasion. The researchers present the first evidence that this neurotrophin receptor can also be a potent mediator of glioma invasion, and they show that the expression of this receptor is sufficient to impart a dramatic invasive behavior on genetically distinct tumors. These data highlight a previously unknown function of this receptor and suggest it may be a novel therapeutic target in the treatment of this devastating cancer.


'"/>

Contact: Natalie Bouaravong
press@plos.org
415-568-3445
Public Library of Science
13-Aug-2007


Page: 1

Related biology news :

1. Invasion of the island bats
2. Preclinical study links gene to brain aneurysm formation
3. Gene variant is associated with brain anatomy, clinical course of ADHD
4. Human knowledge is based upon directed connectivity between brain areas
5. A sensory organ, not the brain, differentiates male and female behavior in some mammals
6. Reading ability protects brain from lead exposure
7. Strength of connections between brain regions may affect an adolescents response to peer influence
8. Females more prone to brain damage from alcohol abuse
9. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
10. Drug protects brain cells in Huntingtons disease model, researchers find
11. Steroids, not songs, spur growth of brain regions in sparrows

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... 18, 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology ... and Drug Administration (FDA) has approved the company’s Investigational New Drug (IND) application ... COVID-19. Approval of this IND allows Sentien to initiate a Phase 1/2 study ...
(Date:8/12/2020)... , ... August 12, 2020 , ... ... monitoring systems that are ideal for public health agencies of all sizes. With ... diseases and helping at-risk individuals find appropriate health care, Mosio helps public health ...
(Date:7/31/2020)... (PRWEB) , ... July 30, 2020 , ... ... Research (SBIR) Phase II contract awarded by the Joint Science & Technology Office—Chemical ... this project is to develop, optimize, and scale-up a highly efficient mammalian cell ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... industry, today announced the release of its signature product called Beacon - ... (MSLs) and other field medical professionals. , Beacon helps MSLs streamline ...
(Date:7/18/2020)... , ... July 16, 2020 , ... After research model ... completion of a great surgery is only the beginning of a successful study, while ... community. , Join Brad Gien, Global Head of Surgery from Envigo in ...
(Date:7/18/2020)... Ohio (PRWEB) , ... July 16, 2020 , ... ... data solutions to aid in the early detection and prevention of high-burden diseases, ... to enable US-based hospitals and healthcare organizations to utilize existing data in order ...
(Date:7/10/2020)... ... 2020 , ... Bode Technology, a leading provider ... through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume clinical testing ... provides a turnkey solution that includes a comprehensive collection and virus-management program for ...
Breaking Biology Technology:
Cached News: