HOME >> BIOLOGY >> NEWS
Invasion of the brain tumors

Gliomas are highly malignant and invasive tumors with tendrils that extend far from the primary tumor site, rendering conventional therapies ineffective and leading to an invariably poor prognosis. In a new study published online this week in the open-access journal PLoS Biology, Angela Johnston, Donna Senger, and colleagues at the University of Calgary injected immunocompromised mice with human gliomas and compared invasive cells (which left the primary tumor site) to noninvasive cells (which remained at the site of injection) in order to understand the molecular mechanisms underlying this invasive behavior. They identified the neurotrophin receptor p75NTR, which normally functions during development to induce neurite outgrowth and promote neuronal cell death, as an important regulator of glioma invasion. The researchers present the first evidence that this neurotrophin receptor can also be a potent mediator of glioma invasion, and they show that the expression of this receptor is sufficient to impart a dramatic invasive behavior on genetically distinct tumors. These data highlight a previously unknown function of this receptor and suggest it may be a novel therapeutic target in the treatment of this devastating cancer.


'"/>

Contact: Natalie Bouaravong
press@plos.org
415-568-3445
Public Library of Science
13-Aug-2007


Page: 1

Related biology news :

1. Invasion of the island bats
2. Preclinical study links gene to brain aneurysm formation
3. Gene variant is associated with brain anatomy, clinical course of ADHD
4. Human knowledge is based upon directed connectivity between brain areas
5. A sensory organ, not the brain, differentiates male and female behavior in some mammals
6. Reading ability protects brain from lead exposure
7. Strength of connections between brain regions may affect an adolescents response to peer influence
8. Females more prone to brain damage from alcohol abuse
9. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
10. Drug protects brain cells in Huntingtons disease model, researchers find
11. Steroids, not songs, spur growth of brain regions in sparrows

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2019)... N.C. (PRWEB) , ... January ... ... a clinical research organization headquartered in Morrisville, NC, providing full, customizable clinical ... with LaunchBio, Inc. to support educational programs for early stage life science ...
(Date:1/25/2019)... SAN FRANCISCO (PRWEB) , ... January 24, 2019 ... ... addition of Dr. Julia Oh, PhD, Assistant Professor of Microbiology at the Jackson ... and doctors from around the world, Dr. Oh will bring to uBiome expertise ...
(Date:1/24/2019)... CAMBRIDGE, Mass. (PRWEB) , ... January 23, 2019 ... ... announced today that it has received a Notice of Allowance from the United ... “Microparticle Multiplexing” filed by its affiliate company, DNA Medicine Institute (DMI). This application ...
Breaking Biology News(10 mins):
(Date:1/24/2019)... ... January 22, 2019 , ... Controlled Contamination Services is pleased to announce ... Each of these valuable new team members will support its growing operation across the ... as CCS scales its business. This addition will enable CCS to widen its reach ...
(Date:1/20/2019)... ... 16, 2019 , ... On January 15 of this year, the Parents’ Guide ... director James L. Sherley, M.D., Ph.D. The PGCB was founded by former ... CellTrials.org. Now in its 21st year of operation, the PGCB continues its mission ...
(Date:1/15/2019)... ... January 15, 2019 , ... Personalized treatment plans may extend life expectancy ... to a new study published in the journal Radiology. , Kidney, or renal, ... nephrectomy, a surgical procedure in which the tumor and part of the kidney are ...
(Date:1/10/2019)... ... January 08, 2019 , ... ... implant company, announced today that SAGICO will be represented at the 37th ... J.P. Morgan Healthcare Conference is the largest and most informative healthcare investment ...
Breaking Biology Technology:
Cached News: