HOME >> BIOLOGY >> NEWS
Iron exporter revealed that may explain common human disorder

The first direct evidence that a single protein is critical in the cellular export of iron may help to explain human hemochromatosis, researchers report in the March issue of Cell Metabolism.

Hemochromatosis--which affects one in every 200 to 300 people in Western populations --causes tissues of the body to become overloaded with iron. Left untreated, the hereditary disease can lead to organ failure.

The new work, led by researchers at the Children's Hospital Boston and Harvard Medical School, finds that the protein ferroportin is the major, if not the only, iron exporter that functions in key sites of iron absorption and release in the body. The findings suggest that the iron accumulation seen in those with hemochromatosis may stem from a loss of control over iron export through ferroportin, the researchers said.

"Iron is essential in the body and abundant in the environment, but it's also very reactive and damaging when in excess," said Nancy Andrews, senior author of the study. "Mammals have therefore evolved mechanisms to get enough iron from the diet, but not too much."

Iron is an essential ingredient of hemoglobin, the protein molecule in red blood cells that carries oxygen from the lungs to the body's tissues. Unlike other metals, iron cannot be eliminated through the liver or kidneys, Andrews explained. Iron balance is maintained instead through the complex regulation of tissues that transport, store, and utilize iron.

Mammals, including humans, initially obtain iron from their mothers. After birth, the intestine absorbs dietary iron and releases it into the bloodstream where developing red blood cells incorporate the iron into hemoglobin. When red blood cells die, macrophage cells consume them and recycle the iron they contain. Macrophages and liver cells also store any excess iron.

Earlier work had identified a single protein that imports iron into cells. However, the evidence for ferroportin's role in expor
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
15-Mar-2005


Page: 1 2 3

Related biology news :

1. Universes stringy birth revealed by young Czech scientist in EURYI winning project
2. Discredited Korean embryonic stem cells true origins revealed
3. Toxoplasmosis infection trick revealed by scientists
4. Genetic roots of bipolar disorder revealed by first genome-wide study of illness
5. Quantum secrets of photosynthesis revealed
6. New bird, bat species revealed by extensive DNA barcode studies
7. Architectural plan revealed of doomsday arctic seed vault
8. Humans ecological footprint in 2015 and Amazonia revealed
9. Secrets revealed in sequencing of honey bee genome
10. Novel biomarker for prediction of survival in colorectal carcinomas revealed
11. Cells fight against cancer revealed

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/8/2019)... GREENWICH, Conn. and TORONTO (PRWEB) , ... May ... ... a growth recapitalization of Axiom Real-Time Metrics (“Axiom”), a premier provider of unified ... I, II and III clinical trials and observational studies. Axiom is a leading ...
(Date:5/7/2019)... , ... May 07, 2019 , ... ... first on-site Legionella DNA test in the UK. , In May, Landsec will ... Legionella results in 45 minutes, enabling operators to take corrective action within hours ...
(Date:5/2/2019)... ... April 30, 2019 , ... Philadelphia intellectual property law ... that Gunes Bender, Ph.D., a registered patent agent, has joined the firm as ... role, Bender provides technical support and scientific expertise in the pharmaceutical and biotechnical ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... More than three thousand ... Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday (25), during ... results of some research carried out by the association, in partnership with scientists ...
(Date:5/2/2019)... ... 30, 2019 , ... The centuries old practice of brewing beer thrives today ... breweries, and even home brewing clubs scattered across the nation. , But proper ... mastered can produce a superb product. Students at South Dakota School of Mines ...
(Date:5/2/2019)... (PRWEB) , ... May 02, 2019 , ... ... transplantation clinic in the greater Boston area. Gone are the days of painful ... ARTAS® iX Robotic Hair Restoration System is the only robotic intelligent solution to ...
(Date:4/18/2019)... ... April 18, 2019 , ... Taking ... that includes a chemical engineer at Worcester Polytechnic Institute (WPI) has developed a ... it possible to manufacture isobutanol and other biofuels more economically. , Isobutanol, like ...
Breaking Biology Technology:
Cached News: