HOME >> BIOLOGY >> NEWS
Iron exporter revealed that may explain common human disorder

ting iron back out of cells remained indirect. To determine which cells depend on ferroportin, the researchers inactivated the protein in mice, both globally and in select tissues.

Animals completely lacking ferroportin died early in development due to a failure of iron transfer from mother to embryo. Mice deficient for ferroportin in all tissues except those critical for maternal nutrient transfer survived but quickly became anemic after birth due to iron deficiency in the blood. Examination of the animals' intestine, liver, and spleen revealed an accumulation of iron within cells, indicating an inability of cells to release iron once absorbed.

Mice lacking ferroportin only in intestinal cells also developed severe iron deficiency anemia, further confirming the protein's role in iron absorption.

The findings offer insight into the underlying basis for hemochromatosis, Andrews said. The researchers propose that, in patients with the disease, perturbations in iron homeostasis result from a failure to control iron export through ferroportin, leading to increased iron release from macrophages and enhanced intestinal absorption. Indeed, patients with the disease exhibit a deficiency of hepcidin, a hormone that binds ferroportin and targets it for destruction.

Drugs that inhibit or degrade ferroportin might therefore curb the iron overload suffered by those with hemochromatosis, Andrews said. Those with excess iron for other reasons, such as repeated blood transfusions, might also benefit from such a drug, she added.

The other members of the research team include Adriana Donovan from Children's Hospital Boston and Harvard Medical School; Christine A. Lima from Children's Hospital Boston and Howard Hughes Medical Institute; Jack L. Pinkus and Geraldine S. Pinkus from Brigham and Women's Hospital; Leonard I. Zon and Nancy C. Andrews from Children's Hospital Boston, Harvard Medical School, and Howard Hughes Medical Institute; and Sylv
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
15-Mar-2005


Page: 1 2 3

Related biology news :

1. Universes stringy birth revealed by young Czech scientist in EURYI winning project
2. Discredited Korean embryonic stem cells true origins revealed
3. Toxoplasmosis infection trick revealed by scientists
4. Genetic roots of bipolar disorder revealed by first genome-wide study of illness
5. Quantum secrets of photosynthesis revealed
6. New bird, bat species revealed by extensive DNA barcode studies
7. Architectural plan revealed of doomsday arctic seed vault
8. Humans ecological footprint in 2015 and Amazonia revealed
9. Secrets revealed in sequencing of honey bee genome
10. Novel biomarker for prediction of survival in colorectal carcinomas revealed
11. Cells fight against cancer revealed

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/23/2018)... , ... November 23, 2018 , ... ... Emeran Mayer, MD, Executive Director of the G. Oppenheimer Center for Neurobiology of ... scientists and doctors from around the world, Dr. Mayer will bring to uBiome ...
(Date:11/20/2018)... ... ... Thanks to its long-standing expertise in ID reader development and industrialization, Elyctis is ... now proposes a full range of readers able to satisfy all needs including usage ... by professionals either in a fixed location or on the move as well as ...
(Date:11/16/2018)... PHILLADELPHIA (PRWEB) , ... November 16, 2018 , ... ... Jr., P.G., was awarded the International Bottled Water Association’s (IBWA’s) IBWA/Shayron Barnes-Selby ... week. , IBWA’s Advocacy Award, named “The Selby” after longtime IBWA contributor Shayron ...
Breaking Biology News(10 mins):
(Date:11/5/2018)... ... 05, 2018 , ... USARAD Holdings Inc., the leading US ... healthcare VC firms announces at Distributed Health 2018 conference November 5-6 (Nashville, TN) ... and obtaining its first radiology interpretations, one of the first known true use ...
(Date:11/3/2018)... ... 01, 2018 , ... Come to Princeton Nov. 14 and ... Division of Clinical Compliance Evaluation, CDER, FDA will be presenting on using data ... should clinical research industry stakeholders keep in mind when implementing and managing risk-based ...
(Date:10/31/2018)... ... 30, 2018 , ... Myoscience, Inc. announced today that it ... Memphis, Tennessee. This study enrolled 125 patients and compares the effect of ... after total knee replacement surgery (TKA). , The Myoscience iovera° system is currently ...
(Date:10/31/2018)... ... 2018 , ... Today, the National Corn Growers Association (NCGA) announced the launch ... to find new and innovative uses of field corn. NineSigma is serving as the ... of corn and are on pace to produce the second largest crop ever. One ...
Breaking Biology Technology:
Cached News: