Rose, 78, shares the prize with Aaron Ciechanover and Avram Hershko of the Israel Institute of Technology for their discovery of the major pathway through which cellular building blocks called ubiquitin proteins are regulated by degradation. Cancer and some neurodegenerative diseases are thought to be related to disruptions in this pathway.
From the work of Rose, Ciechanover and Hershko, it is now possible to understand at the molecular level how modification by attachment of ubiquitin results in breakdown of unwanted proteins inside cells. In addition, it is now known that other modifiers, similar to ubiquitin, are used by the cell to regulate proteins in many ways. These findings are playing a key role in the development of drugs to fight illnesses such as cancer and cystic fibrosis.
"The basic science faculty at the College of Medicine and our clinical faculty at UCI Medical Center are delighted and pleased that Dr. Rose has been recognized for his significant contribution to our understanding of ubiquitin, and its potential role in the treatment of disease," said College of Medicine Dean Thomas Cesario.
Rose came to UCI in 1997 from the Fox Chase Cancer Center in Philadelphia. He is a member of the Department of Physiology and Biophysics. The Brooklyn-born Rose received his doctorate in biochemistry in 1952 from the University of Chicago.
Rose, a member of the National Academy of Sciences, currently lives in Laguna Woods. He is the third UCI researcher to earn this honor. In 1995, Nobel Prizes were awarded to F. Sherwood Rowland in chemistry and Frederick Reines in physics.