HOME >> BIOLOGY >> NEWS
It's not all genetic: Common epigenetic problem doubles cancer risk in mice

In experiments with mice, a team of scientists from the United States, Sweden and Japan has discovered that having a double dose of one protein is sufficient to change the normal balance of cells within the lining of the colon, thereby doubling the risk that a cancer-causing genetic mutation will trigger a tumor there. Roughly 10 percent of people have this double protein dose as well.

In the Feb. 24 online version of Science, the researchers report that mice engineered to have a double dose of insulin-like growth factor 2 (IGF2) develop more so-called precursor cells within the lining of the colon than normal mice. When these mice also carried a colon-cancer-causing genetic mutation, they developed twice as many tumors as those with normal IGF2 levels, the researchers report.

"Both clinically and scientifically, this discovery should expand attention in colon cancer research to earlier events, situations present well before tumors appear," says the study's leader, Andrew Feinberg, M.D., M.P.H., professor of medicine and director of the Center for Epigenetics in Common Human Disease at Johns Hopkins.

"In the mice with a double dose of IGF2, everything is pretty normal except for the extra precursor cells," says Christine Iacobuzio-Donahue, M.D., assistant professor of pathology and oncology. "But when the genetic mutation is present, too, we found a clear cost for what otherwise appears to be a benign effect of extra IGF2."

The team's analysis of colon tissue samples from a dozen or so Johns Hopkins patients with suspected colon cancer suggests that IGF2's effect in people may be similar, the researchers report. A larger study of samples from patients with and without suspected colon cancer is underway, Feinberg notes.

In the mice -- as well as in about 30 percent of colon cancer patients and 10 percent of the general population -- the extra IGF2 stems not from a genetic problem, or mutation, but an "epigenetic" prob
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
24-Feb-2005


Page: 1 2 3

Related biology news :

1. Common environmental chemicals in diet affect fetal ovarian development
2. Common cancer gene sends death order to tiny killer
3. Common treatment for methamphetamine overdose may damage brain cells
4. Common genetic variation is linked to substantial risk for heart attack
5. Common fungicide causes long-term changes in mating behavior
6. DNA ends: Common tool, different job
7. Common gene version optimizes thinking -- but with a possible downside
8. Common mechanisms for viral DNA replication
9. Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia
10. Common cause of heart disease, diabetes may be treatable with malaria drug
11. Commonplace sugar compound silences seizures

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2019)... , ... August 20, 2019 , ... ... and commercialization of bioactive technologies for the spine, today announced the 510(K) clearance ... a unique surface modification that is proven to improve osseointegration through superior hydrophilicity ...
(Date:8/15/2019)... TORONTO (PRWEB) , ... August 15, 2019 , ... ... finally passed. Now what? As serialization mandates become increasingly complex, and aggregation becomes ... their current serialization software is the best long-term solution. , Until now, most ...
(Date:8/14/2019)... ... ... Join Jonathan Riek, PhD, VP, Musculoskeletal & Metabolic Imaging, BioTel Research ... EDT to learn about two common imaging methods in NAFLD/NASH to aid with early ... diffuse liver disease, with a worldwide prevalence of 20-46 percent. NAFLD can be subdivided ...
Breaking Biology News(10 mins):
(Date:9/17/2019)... , ... September 16, 2019 , ... ... via CNBC on Saturday, September 21st @11:00am ET. Check local listings for more ... Ltd. (Credo Biomedical), a molecular diagnostic company from Singapore dedicated to developing ...
(Date:9/11/2019)... ... September 10, 2019 , ... Catalent, the leading global provider ... and consumer health products, today announced that Alex Haig, Senior Director, Engineering will ... AG, Schwabisch Hall, Germany, on Sept. 18-19, 2019. , On Wednesday, Sept. 18 ...
(Date:9/2/2019)... , ... September 02, 2019 , ... ... and in vitro diagnostics, has launched the industry’s first epigenetics data mining services ... meaning of epigenetic data and other data types. , Next generation sequencing in ...
(Date:8/27/2019)... HOUSTON (PRWEB) , ... August 27, 2019 , ... ... chain engineering firm, is pleased to announce it has promoted Consulting Engineer, Robert ... Solutions, Battista has added the responsibility of onboarding and mentoring new engineers as ...
Breaking Biology Technology:
Cached News: