HOME >> BIOLOGY >> NEWS
J&JPRD discovery may lead to new treatments for chronic sensitivity, pain caused by cold

Raritan, NJ (May 2, 2007) -- Researchers at Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD) today announced that they have discovered a biological basis for explaining how people sense cold temperatures.

Ultimately, these findings may be a critical step in developing treatments for patients who suffer from hypersensitivity to cold, such as occurs in neuropathic pain and complex regional pain syndromes. This research is published in the May 3, 2007 issue of Neuron.

In the study, researchers sought to understand the mechanisms underlying cold sensitivity. Scientists used a line of mice that lacked a critical ion channel receptor called TRPM8, also referred to as the cold menthol receptor 1. Then, they tested how these mice reacted to cold stimuli, and found that not having these receptors reduced their adverse reactions to the cold, both under normal and pathological conditions. Results suggest that TRPM8 modulation could play an important role in certain types of cold-induced pain in humans and could hold therapeutic potential in the treatment of many chronic, painful conditions for which there are currently limited effective treatment options.

"This work represents the culmination of a multi-year collaborative effort on the part of J&JPRD scientists to help explain fundamental mechanisms involved in human pain states and may lead to the development of innovative medicines to relieve patient suffering," said Christopher Flores, Ph.D., Biology Team Leader for Analgesics, J&JPRD. "Although preliminary, these findings provide compelling initial evidence toward validating TRPM8 as an analgesic drug target and addressing major unmet medical needs of pain patients."

Ion channels are proteins that form tiny openings through the membrane of a cell and allow the passage of certain ions that regulate cellular activities. Some of these channels are opened by chemicals, some by changes in voltage and othe
'"/>

Contact: Lisa Vaga
lvaga@prdus.jnj.com
908-218-7316
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2-May-2007


Page: 1 2

Related biology news :

1. Enzyme discovery sheds light on vitamin D
2. New proteomics research promises to revolutionize biomedical discovery
3. MU researchers make discovery in molecular mechanics of phototropism
4. International team to honor 30th anniversary of deep-sea vent discovery in Galpagos
5. Screening approach leads to discovery of gene linked to breast cancer
6. Lucky 13 as new gene discovery offers further hope for childhood blindness
7. Plants that produce more vitamin C may result from UCLA-Dartmouth discovery
8. Biting discovery: MU entomologist finds host of new aquatic insect species in Thailand
9. Protein enables discovery of quantum effect in photosynthesis
10. Unicellular microRNA discovery
11. Jefferson researchers discovery may change thinking on how viruses invade the brain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
Cached News: