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JCI Table of Contents, June 15 2006

EGF receptor activation prevents microbes from going more than skin deep

Our skin not only serves as a physical barrier against infection but skin cells themselves can mount an immune response to kill invading microbes by producing antimicrobial polypeptides (AMPs). As overt infection in the skin is a rare event, researchers have theorized that AMPs must not only help fight infection, but play a role in preventing infection from developing in the first place. In a study appearing online on June 15 in advance of print publication in the July issue of the Journal of Clinical Investigation, Ole Sorensen and colleagues from Lund University, Sweden, investigated what triggers AMP production in human skin. Interestingly, they found that AMPs were produced in human skin after sterile wounding of the skin surface, illustrating that exposure to invading microbes is not the sole trigger for the immune response in skin.

The authors went on to show that AMP was produced through activation of the epidermal growth factor receptor (EGFR), which is known to play a role in the normal wound-healing process. The authors found that the antibacterial activity of the skin against the potential skin pathogen Staphylococcus aureus was increased by activation of EGFR, and that the concentrations of AMPs in the epidermis of wounded skin exceeded those necessary to suppress or prevent the growth of foreign microbes. The results of this study demonstrate that wounding of the skin alone, without the presence of microbes, is sufficient to activate defense mechanisms in the skin that can prevent microbial growth and related harmful skin infections.

TITLE: Injury-induced innate immune response in human skin is mediated by transactivation of the epidermal growth factor receptor

AUTHOR CONTACT:
Ole E. Sorensen
Lund University, Lund, Sweden.
Phone: 46-46-222-4472; Fax: 46-46-155-7756; E-mail: Ole_E.Sorens
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Contact: Ushma Neill
editors@the-jci.org
212-342-0498
Journal of Clinical Investigation
15-Jun-2006


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