diated lipid uptake and atherogenesis. The CD36 and SR-A null mice had increased aortic lesion areas, compared to controls. The lesions appeared to be more advanced than those seen in the control mice. These results suggest that scavenger receptor-mediated lipid uptake is not pro-atherosclerotic, as has been reported. In fact, the data presented suggest that scavenger receptor function is protective in atherosclerosis.

In an accompanying commentary, Joseph Witztum discusses potential reasons for the discordant results. He mentions that the reasons why the data are different from previous studies is not quite clear, but that the "data presented by Moore, et al. will cause all of us to stop and reevaluate and to undertake much more experimentation and thought."

TITLE: Loss of lipid uptake via class A scavenger receptors or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice

AUTHOR CONTACT:
Mason Freeman
Massachusetts General Hospital, Boston, MA USA
Phone: 617-726-5906; Fax: 617-726-2879; E-mail: freeman@molbio.mgh.harvard.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=24061

ACCOMPANYING COMMENTARY:

TITLE: You are right too!

AUTHOR CONTACT:
Joseph L. Witztum
University of California San Diego, La Jolla, CA USA
Phone: 858-534-4347; Fax: 858-534-4347; E-mail: jwitztum@ucsd.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=26130

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Contact: Stacie Bloom
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
1-Aug-2005

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